5-chloro-3-hydroxyisothiazole
- Product Name
- 5-chloro-3-hydroxyisothiazole
- CAS No.
- 25629-58-7
- Chemical Name
- 5-chloro-3-hydroxyisothiazole
- Synonyms
- hydroxyisothiazole;5-chloroisothiazol-3-ol;5-Chloro-3-isothiazolol;5-chloroisothiazol-3-one;5-Chloroisothiazol-3(2H)-one;5-Chloro-3(2H)-isothiazolone;5-chloro-3-hydroxyisothiazole;5-Chloro-4-isothiazolin-3-one;3(2H)-Isothiazolone, 5-chloro-;5-chloro-3(2H)-Isothiazolone 97%
- CBNumber
- CB92549513
- Molecular Formula
- C3H2ClNOS
- Formula Weight
- 135.57
- MOL File
- 25629-58-7.mol
5-chloro-3-hydroxyisothiazole Property
- Melting point:
- 96-97 °C(Solv: water (7732-18-5))
- Density
- 1.62±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 7.20±0.40(Predicted)
Safety
- HS Code
- 2934100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- B423970
- Product name
- 5-chloroisothiazol-3-ol
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B423970
- Product name
- 5-chloroisothiazol-3-ol
- Packaging
- 100mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- 094246
- Product name
- 5-Chloroisothiazol-3-ol
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $385
- Updated
- 2021/12/16
- Product number
- Z4502
- Product name
- 5-Chloroisothiazol-3-ol
- Packaging
- 1g
- Price
- $440
- Updated
- 2021/12/16
- Product number
- Z4502
- Product name
- 5-Chloroisothiazol-3-ol
- Packaging
- 100mg
- Price
- $143
- Updated
- 2021/12/16
5-chloro-3-hydroxyisothiazole Chemical Properties,Usage,Production
Synthesis
5-chloro-3-hydroxyisothiazole can be synthesized from 3,3'-disulfanediyldipropionic acid and Thionyl chloride in three steps. In particular, in the last step, 5-chloro isothiazolone derivatives (5-chloro-3-hydroxyisothiazole) were the predominant products when the ratio of sulfuryl chloride/amide was 3:1 while with the relevant ratio of 1:1, the 5-unsubstituted analogs were the predominant products[1].
References
[1] Khalaj A, et al. Synthesis and antibacterial activity of 2-(4-substituted phenyl)-3(2H)-isothiazolones. European Journal of Medicinal Chemistry, 2004; 39: 285–290.
5-chloro-3-hydroxyisothiazole Preparation Products And Raw materials
Raw materials
Preparation Products
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