ChemicalBook > CAS DataBase List > Nortadalafil

Nortadalafil

Product Name
Nortadalafil
CAS No.
171596-36-4
Chemical Name
Nortadalafil
Synonyms
Nortadalafil;DeMethyltadalafil;N-demethyltadalafil;Tadalafil IMpurity J;N-DesMethyl Tadalafil;Tadalafil Impurity 21;Demethyltadalafil impurity;Tadalafil IMpurity:IMpurity C;Tadanafil N-desmethyl impurity;Nortadalafil/Demethyl Tadalafil
CBNumber
CB92549609
Molecular Formula
C21H17N3O4
Formula Weight
375.38
MOL File
171596-36-4.mol
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Nortadalafil Property

Melting point:
285-290℃ (methanol )
Boiling point:
718.6±60.0 °C(Predicted)
Density 
1.55±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated)
form 
Solid
pka
13.53±0.40(Predicted)
color 
White to Pale Yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
D293800
Product name
N-DesmethylTadalafil
Packaging
5mg
Price
$185
Updated
2021/12/16
ApexBio Technology
Product number
A3665
Product name
Nortadalafil
Packaging
5mg
Price
$213
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD21326
Product name
N-Desmethyl tadalafil
Packaging
5mg
Price
$285
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0010360
Product name
NORTADALAFIL
Purity
95.00%
Packaging
5MG
Price
$322.3
Updated
2021/12/16
ApexBio Technology
Product number
A3665
Product name
Nortadalafil
Packaging
10mg
Price
$331
Updated
2021/12/16
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Nortadalafil Chemical Properties,Usage,Production

Uses

A N-desmethyl analogue of the human PDE5 inhibitor Tadalafil (T004500). A potential antiplasmodial drug.

Biological Activity

the cgmp-specific pde5 is the major pde isozyme in the corpus cavernosum, and controls penile erection. the pde5 inhibitors used in the clinic amplify the no-ccmp pathway and enhance the normal process leading to penile erection.nortadalafil is demethyl tadalafil, which is a pde5 inhibitor currently marketed in pill form for treating erectile dysfunction under the name cialis and for the treatment of pulmonary arterial hypertension under the name adcirca.

in vitro

tadalafil has been identified as a highly potent pde5 inhibitor (ic50 = 5 nm) with high selectivity for pde5 vs pde1-4 and pde6. it displays 85-fold greater selectivity vs pde6 than sildenafil [1].

in vivo

tadalafil showed profound and long-lasting blood pressure lowering activity (30 mmhg/>7 h) in the spontaneously hypertensive rat model after oral administration (5 mg/kg) [1].

target

PDE5

IC 50

n/a for nortadalafil; 5 nm for tadalafil

References

[1] daugan a, grondin p, ruault c, le monnier de gouville ac, coste h, linget jm, kirilovsky j, hyafil f, labaudinière r. the discovery of tadalafil: a novel and highly selective pde5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues. j med chem. 2003;46(21):4533-42.
[2] porst h, hell-momeni k, büttner h. chronic pde-5 inhibition in patients with erectile dysfunction - a treatment approach using tadalafil once-daily. expert opin pharmacother. 2012 jul;13(10):1481-94. doi: 10.1517/14656566.2012.693162.

Nortadalafil Preparation Products And Raw materials

Raw materials

Preparation Products

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Nortadalafil Suppliers

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View Lastest Price from Nortadalafil manufacturers

Jiangsu Monade Biological Technology Co., Ltd.
Product
Nortadalafil 171596-36-4
Price
US $0.00/ASSAYS
Min. Order
100ASSAYS
Purity
99.99
Supply Ability
10000
Release date
2021-09-10
Career Henan Chemical Co
Product
Nortadalafil 171596-36-4
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-01-02

171596-36-4, NortadalafilRelated Search:

Tetryzoline (1R,3R)-2-acetyl-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro- 1H-pyrido[3,4-b]indole-3-carboxylate (1S,3S)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester (1S,3S)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester (1R,3S)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester (1S,3R)-1-Benzo[1,3]dioxol-5-yl-2-(2-chloro-acetyl)-2,3,4,9-tetrahydro-1H-b-carboline-3-carboxylic Acid Methyl Ester 2-Hydroxypropyl Nortadalafil cis-ent-Tadalafil (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(dimethylglycyl)-2,3,4,9-tetrahydro-1H-pyrido [3,4-b]indole-3-carboxylate methyl (1R,3S)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester Chloropretadalafil cis-Tadalafil D(+)-Tryptophan Tadalafil iMpurity B Tadalafil KetolactaM Tadalafil JLEQLXGZAIAEFX-VRQJEYPFSA-N Tadalafil EP Impurity

  • DeMethyltadalafil
  • N-DesMethyl Tadalafil
  • (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
  • Tadalafil Impurity 21
  • (6R-trans)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
  • Nortadalafil
  • Tadalafil IMpurity:IMpurity C
  • Pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, 6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-, (6R,12aR)-
  • (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, N-DesMethyl Tadalafil
  • Tadalafil IMpurity J
  • Tadanafil N-desmethyl impurity
  • Tetrahydropalmatine Solution, 100ppm
  • Tadalafil Impurity 21(N-Desmethyl Tadalafil)
  • Nortadalafil Solution in Methanol, 100μg/mL
  • N-demethyltadalafil
  • (6R,12aR)-6-(Benzo[d][1,3]dioxol-5-yl)-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione? (Tadalafil Impurity)
  • (6R,12aR)-6-(Benzo[d][1,3]dioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
  • Nortadalafil/Demethyl Tadalafil
  • N-Desmethyl tadalafil in methanol
  • (6R,12aR)-6-(Benzo[d][1,3]dioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
  • Demethyltadalafil impurity
  • 171596-36-4
  • 172596-36-4
  • Aromatics
  • Drug Analogues
  • Heterocycles
  • Indole Derivatives
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals