2-Iodo-4-(trifluoroMethyl)phenol

Product Name: 2-Iodo-4-(trifluoroMethyl)phenol
CAS No.: 463976-21-8
Chemical Name: 2-Iodo-4-(trifluoroMethyl)phenol
Synonyms: 2-Iodo-4-(trifluoromethyl);4-Trifluoromethyl-6-iodophenol;2-Iodo-4-(trifluoroMethyl)phenol;Phenol, 2-iodo-4-(trifluoromethyl)-;2-Iodo-4-(trifluoromethyl)phenol,97%;alpha,alpha,alpha-Trifluoro-o-iodo-p-cresol
CBNumber: CB92549780
Molecular Formula: C7H4F3IO
Formula Weight: 288.01
MOL File: 463976-21-8.mol

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2-Iodo-4-(trifluoroMethyl)phenol Property

Boiling point:: 105℃/44mm
refractive index: 1.5405
storage temp.: 2-8°C(protect from light)
form: liquid
color: clear
Sensitive: Light Sensitive

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Safety

Risk Statements: 34
Safety Statements: 20-23-26-36/37/39-45-60
TSCA: No
HazardClass: 8

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: I737313
Product name: 2-Iodo-4-(trifluoromethyl)phenol
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: I737313
Product name: 2-Iodo-4-(trifluoromethyl)phenol
Packaging: 100mg
Price: $75
Updated: 2021/12/16

ChemSupplyAustralia

Product number: 300318
Product name: 2-Iodo-4-(trifluoromethyl)phenol, 98%
Packaging: 250mg
Price: $49.5
Updated: 2021/12/16

ChemScene

Product number: CS-W010010
Product name: 2-Iodo-4-(trifluoromethyl)phenol
Purity: >98.0%
Packaging: 1g
Price: $56
Updated: 2021/12/16

AK Scientific

Product number: 6365AB
Product name: 2-Iodo-4-(trifluoromethyl)phenol
Packaging: 1g
Price: $118
Updated: 2021/12/16

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2-Iodo-4-(trifluoroMethyl)phenol Chemical Properties,Usage,Production

Uses

2-Iodo-4-(trifluoromethyl)phenol is an pharmaceutical intermediate and it is an intermediate in organic synthesis.

Synthesis

402-45-9

463976-21-8

S3. 4-(Trifluoromethyl)phenol (6) (241 mmol, 39 g) was dissolved in a solvent mixture of tetrahydrofuran (200 mL) and water (200 mL) under stirring conditions. Iodine (265 mmol, 67 g) and sodium carbonate (265 mmol, 28 g) were added sequentially. The reaction mixture was stirred at room temperature for 24 h. The progress of the reaction was monitored by TLC until 4-(trifluoromethyl)phenol (6) was fully reacted. Post-treatment step: 5% aqueous thiourea solution was added to quench unreacted iodine, followed by three extractions with ether. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography with the eluent being a mixed solvent of petroleum ether and dichloromethane (the volume ratio was tapered from 10:1 to 6:1) to afford the target compound 2-iodo-4-(trifluoromethyl)phenol (7) (42.7 g) in 63% yield.

References

[1] Patent: US2002/143017, 2002, A1
[2] Patent: CN106397425, 2017, A. Location in patent: Paragraph 0019; 0040; 0041
[3] Patent: CN106397426, 2017, A. Location in patent: Paragraph 0044; 0045; 0058; 0062
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 16, p. 7029 - 7042
[5] Journal of Medicinal Chemistry, 2005, vol. 48, # 20, p. 6326 - 6339

2-Iodo-4-(trifluoroMethyl)phenol Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Iodo-4-(trifluoroMethyl)phenol Suppliers

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463976-21-8