ChemicalBook > CAS DataBase List > 2,6-dichloro-N-Methyl pyriMidin-4-aMine

2,6-dichloro-N-Methyl pyriMidin-4-aMine

Product Name: 2,6-dichloro-N-Methyl pyriMidin-4-aMine
CAS No.: 10397-15-6
Chemical Name: 2,6-dichloro-N-Methyl pyriMidin-4-aMine
Synonyms: 100066;NSC 90604;4,6-Dichloro-N-methyl-2-pyrimidinamine;4,6-dichloro-N-MethylpyriMidin-2-aMine;2,6-dichloro-N-Methyl pyriMidin-4-aMine;2-PyriMidinaMine,4,6-dichloro-N-Methyl-;4,6-DICHLORO-N-METHYL-PYRIMIDINE-2-AMINE
CBNumber: CB92551808
Molecular Formula: C5H5Cl2N3
Formula Weight: 178.02
MOL File: 10397-15-6.mol

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2,6-dichloro-N-Methyl pyriMidin-4-aMine Property

Melting point:: 164 °C
Boiling point:: 295.7±43.0 °C(Predicted)
Density: 1.492
refractive index: 1.619
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 0.45±0.25(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: D436148
Product name: 4,6-Dichloro-N-methylpyrimidin-2-amine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 071120
Product name: 4,6-Dichloro-N-methylpyrimidin-2-amine
Purity: 97%
Packaging: 1g
Price: $200
Updated: 2021/12/16

Apolloscientific

Product number: OR370069
Product name: 4,6-Dichloro-N-methylpyrimidin-2-amine
Packaging: 1g
Price: $279
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H31-5-9F
Product name: 4,6-Dichloro-N-methylpyrimidin-2-amine
Purity: 98.0%
Packaging: 1g
Price: $330
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0225919
Product name: 4,6-DICHLORO-N-METHYLPYRIMIDIN-2-AMINE
Purity: 95.00%
Packaging: 5MG
Price: $496.08
Updated: 2021/12/16

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2,6-dichloro-N-Methyl pyriMidin-4-aMine Chemical Properties,Usage,Production

Synthesis

3764-01-0

74-89-5

10397-15-6

32998-03-1

The general procedure for the synthesis of 4,6-dichloro-N-methylpyrimidin-2-amine and 2,6-dichloro-N-methylpyrimidin-4-amine from 2,4,6-trichloropyrimidine (0.50 g, 2.7 mmol) and monomethylamine (2M THF solution, 3.0 mL, 6.0 mmol) is as follows: 2,4,6-trichloropyrimidine was dissolved in THF (3 mL), and dropwise added to the THF solution of methylamine. The reaction mixture was slowly warmed to room temperature and stirred continuously for 30 min, and the reaction progress was monitored by LCMS to confirm the formation of the target product. Upon completion of the reaction, the reaction was quenched with 10 mL of water and subsequently extracted with EtOAc (2 × 10 mL). The organic phases were combined, washed with 10 mL of brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude product was purified by column chromatography (elution gradient: 0-30% EtOAc in hexane solution) to afford 2,6-dichloro-N-methyl-4-pyrimidinamine 180 mg (1.01 mmol, 38% yield) and 4,6-dichloro-N-methyl-2-pyrimidinamine 150 mg (0.85 mmol, 31% yield). The mass spectra (ES+) m/e of both compounds were 178 [M+H]+.

References

[1] Nucleosides and Nucleotides, 1994, vol. 13, # 8, p. 1769 - 1777
[2] Patent: WO2008/105968, 2008, A1. Location in patent: Page/Page column 66-67
[3] Journal fuer Praktische Chemie (Leipzig), 1927, vol. <2> 115, p. 293
[4] Patent: US9433621, 2016, B2. Location in patent: Page/Page column 113; 114; 115; 116
[5] Patent: WO2010/22121, 2010, A1. Location in patent: Page/Page column 147

2,6-dichloro-N-Methyl pyriMidin-4-aMine Preparation Products And Raw materials

Raw materials

Preparation Products

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10397-15-6, 2,6-dichloro-N-Methyl pyriMidin-4-aMineRelated Search:

NSC 90604

4,6-Dichloro-N-methyl-2-pyrimidinamine

2,6-dichloro-N-Methyl pyriMidin-4-aMine

4,6-dichloro-N-MethylpyriMidin-2-aMine

2-PyriMidinaMine,4,6-dichloro-N-Methyl-

4,6-DICHLORO-N-METHYL-PYRIMIDINE-2-AMINE

100066

10397-15-6