2-(5-Methylpyridin-2-yl)acetonitrile

Product Name: 2-(5-Methylpyridin-2-yl)acetonitrile
CAS No.: 38203-08-6
Chemical Name: 2-(5-Methylpyridin-2-yl)acetonitrile
Synonyms: 5-methyl-2-pyridineacetonitrile;2-Pyridineacetonitrile, 5-methyl-;2-(5-Methylpyridin-2-yl)acetonitrile;1-[2-[4-[(3R,4R)-7-methoxy-3-phenyl-3,4-dihydro-2H-1-benzopyran-4-yl]phenoxy]ethyl]pyrrolidine
CBNumber: CB92552274
Molecular Formula: C8H8N2
Formula Weight: 132.16
MOL File: 38203-08-6.mol

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2-(5-Methylpyridin-2-yl)acetonitrile Property

Boiling point:: 105-106 °C(Press: 3 Torr)
Density: 1.056±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 3.47±0.22(Predicted)
Appearance: Light yellow to yellow Liquid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: 6422CC
Product name: 2-(5-Methylpyridin-2-yl)acetonitrile
Packaging: 250mg
Price: $141
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0381142
Product name: 2-(5-METHYLPYRIDIN-2-YL)ACETONITRILE
Purity: 95.00%
Packaging: 5MG
Price: $499.3
Updated: 2021/12/16

Alichem

Product number: 38203086
Product name: 5-Methylpyridine-2-acetonitrile
Packaging: 1g
Price: $572.57
Updated: 2021/12/16

Ambeed

Product number: A450564
Product name: 2-(5-Methylpyridin-2-yl)acetonitrile
Purity: 95%
Packaging: 100mg
Price: $22
Updated: 2021/12/16

Ambeed

Product number: A450564
Product name: 2-(5-Methylpyridin-2-yl)acetonitrile
Purity: 95%
Packaging: 250mg
Price: $43
Updated: 2021/12/16

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2-(5-Methylpyridin-2-yl)acetonitrile Chemical Properties,Usage,Production

Synthesis

3510-66-5

38203-08-6

Step 3 - Preparation of 2-(5-methylpyridin-2-yl)acetonitrile: To a solution of anhydrous acetonitrile (10.1 mL, 191.83 mmol, 3.3 eq.) in anhydrous tetrahydrofuran (500 mL) was added slowly and dropwise at -78 °C a solution of n-butyllithium (2.5 M, 69.8 mL, 174.39 mmol, 3 eq.) in hexanes, protected by nitrogen. The resulting white suspension was stirred at -78 °C for 1 h. Anhydrous tetrahydrofuran (30 mL) solution of 2-bromo-5-methylpyridine (10.0 g, 58.13 mmol, 1 eq.) was added. The reaction mixture was kept at -78 °C for 1 h, followed by a slow warming to room temperature and continued stirring for 1 h. The reaction was completed by the addition of ice water. Upon completion of the reaction, the reaction was quenched by the addition of ice water and layered. The organic layer was washed sequentially with water and brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 18 g of crude product. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=15:1) to afford 2-(5-methylpyridin-2-yl)acetonitrile (6.2 g, 80% yield).1H NMR (300 MHz, CDCl3): δ 8.40 (d, J=3.0 Hz, 1H), 7.54 (dd, J1=3.0 Hz, J2=6.0 Hz. 1H), 7.32 (d, J=6.0 Hz, 1H), 3.90 (s, 2H), 2.40 (s, 3H).

References

[1] Patent: US2009/280230, 2009, A1
[2] Patent: US2009/280230, 2009, A1
[3] Patent: US2009/280230, 2009, A1

2-(5-Methylpyridin-2-yl)acetonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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38203-08-6