1H-Indole-1-carboxylic acid, 5-(hydroxyMethyl)-, 1,1-diMethylethyl ester
- Product Name
- 1H-Indole-1-carboxylic acid, 5-(hydroxyMethyl)-, 1,1-diMethylethyl ester
- CAS No.
- 279255-90-2
- Chemical Name
- 1H-Indole-1-carboxylic acid, 5-(hydroxyMethyl)-, 1,1-diMethylethyl ester
- Synonyms
- (1-Boc-5-indolyl)methanol;1-Boc-1H-indol-5-ylmethanol;tert-butyl 5-(hydroxymethyl)indole-1-carboxylate;5-methylolindole-1-carboxylic acid tert-butyl ester;5-Hydroxymethyl-indole-1-carboxylic acid tert-butyl ester;5-(hydroxymethyl)-1-indolecarboxylic acid tert-butyl ester;1,1-Dimethylethyl 5-(hydroxymethyl)-1H-indole-1-carboxylate;1H-Indole-1-carboxylic acid, 5-(hydroxyMethyl)-, 1,1-diMethylethyl;1H-Indole-1-carboxylic acid, 5-(hydroxyMethyl)-, 1,1-diMethylethyl ester
- CBNumber
- CB92553963
- Molecular Formula
- C14H17NO3
- Formula Weight
- 247.29
- MOL File
- 279255-90-2.mol
1H-Indole-1-carboxylic acid, 5-(hydroxyMethyl)-, 1,1-diMethylethyl ester Property
- Boiling point:
- 396.0±34.0 °C(Predicted)
- Density
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 14.37±0.10(Predicted)
Safety
- HS Code
- 2933998090
N-Bromosuccinimide Price
- Product number
- 9036AD
- Product name
- tert-Butyl5-(hydroxymethyl)-1H-indole-1-carboxylate
- Packaging
- 100mg
- Price
- $128
- Updated
- 2021/12/16
- Product number
- FB125465
- Product name
- tert-Butyl 5-(hydroxymethyl)-1H-indole-1-carboxylate
- Packaging
- 250mg
- Price
- $235
- Updated
- 2021/12/16
- Product number
- 065805
- Product name
- tert-Butyl 5-(hydroxymethyl)-1H-indole-1-carboxylate
- Packaging
- 500mg
- Price
- $266
- Updated
- 2021/12/16
- Product number
- FB125465
- Product name
- tert-Butyl 5-(hydroxymethyl)-1H-indole-1-carboxylate
- Packaging
- 500mg
- Price
- $370
- Updated
- 2021/12/16
- Product number
- 065805
- Product name
- tert-Butyl 5-(hydroxymethyl)-1H-indole-1-carboxylate
- Packaging
- 1g
- Price
- $409
- Updated
- 2021/12/16
1H-Indole-1-carboxylic acid, 5-(hydroxyMethyl)-, 1,1-diMethylethyl ester Chemical Properties,Usage,Production
Synthesis
279256-09-6
279255-90-2
General procedure for the synthesis of tert-butyl 5-(hydroxymethyl)-1H-indole-1-carboxylate from tert-butyl 5-formyl-1H-indole-1-carboxylate: firstly, tert-butyl 5-formyl-1H-indole-1-carboxylate (12.23 mmol) was dissolved in methanol (30 mL) to obtain a solution. To this solution, sodium tetrahydroborate (0.463 g, 12.23 mmol) was slowly added at 0 °C. The reaction mixture was stirred continuously at 0 °C for 3 h, followed by stirring at room temperature overnight. After completion of the reaction, the resulting solution was diluted with water (40 mL) and extracted with ethyl acetate (3 x 30 mL). The organic layers were combined, washed sequentially with aqueous sodium carbonate and brine, dried over anhydrous sodium sulfate, and concentrated in vacuum to afford tert-butyl 5-(hydroxymethyl)-1H-indole-1-carboxylate (2.5 g, 10.11 mmol, 83% yield) as a yellow oil.LCMS analysis showed m/z = 270.3 [M + Na]+.
References
[1] Journal of the American Chemical Society, 2017, vol. 139, # 20, p. 6847 - 6850
[2] Patent: WO2017/216726, 2017, A1. Location in patent: Page/Page column 955
1H-Indole-1-carboxylic acid, 5-(hydroxyMethyl)-, 1,1-diMethylethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Indole-1-carboxylic acid, 5-(hydroxyMethyl)-, 1,1-diMethylethyl ester Suppliers
- Tel
- 021-64340559 13651849907;
- Fax
- 021- 64345308
- xinyu_shi@jwypharmlab.com.cn
- Country
- China
- ProdList
- 12000
- Advantage
- 58
- Tel
- Fax
- -
- 13006575422@163.com
- Country
- China
- ProdList
- 6355
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 025-58859352 18068836627
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 16027
- Advantage
- 58
- Tel
- 13370351217 kungfu1217@1
- Fax
- QQ1400885609
- kungfu1217@163.com
- Country
- China
- ProdList
- 2720
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- 021-50822001
- marketing@medicilon.com.cn
- Country
- China
- ProdList
- 1152
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57422
- Advantage
- 58
- Tel
- zhiqianbio@126.com
- Country
- China
- ProdList
- 19778
- Advantage
- 58
- Tel
- +8618530059196
- sale04@alfachem.cn
- Country
- China
- ProdList
- 11784
- Advantage
- 58