1H-Isoindol-1-one, 4-broMo-2,3-dihydro-6-hydroxy-
Uses- Product Name
- 1H-Isoindol-1-one, 4-broMo-2,3-dihydro-6-hydroxy-
- CAS No.
- 808127-76-6
- Chemical Name
- 1H-Isoindol-1-one, 4-broMo-2,3-dihydro-6-hydroxy-
- Synonyms
- 4-BroMo-6-hydroxyisoindolin-1-one;4-bromo-6-hydroxy-1-isoindolinone;4-BroMo-6-hydroxy-2,3-dihydro-isoindol-1-one;4-Bromo-6-hydroxy-2,3-dihydro-1H-isoindol-1-one;1H-Isoindol-1-one, 4-broMo-2,3-dihydro-6-hydroxy-
- CBNumber
- CB92553978
- Molecular Formula
- C8H6BrNO2
- Formula Weight
- 228.04
- MOL File
- 808127-76-6.mol
1H-Isoindol-1-one, 4-broMo-2,3-dihydro-6-hydroxy- Property
- storage temp.
- 2-8°C
Safety
- HS Code
- 2925199590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B293175
- Product name
- 4-Bromo-6-hydroxyisoindolin-1-one
- Packaging
- 25mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- FB141404
- Product name
- 4-Bromo-6-hydroxyisoindolin-1-one
- Packaging
- 50mg
- Price
- $82
- Updated
- 2021/12/16
- Product number
- FB141404
- Product name
- 4-Bromo-6-hydroxyisoindolin-1-one
- Packaging
- 100mg
- Price
- $142
- Updated
- 2021/12/16
- Product number
- Z5148
- Product name
- 4-Bromo-6-hydroxyisoindolin-1-one
- Packaging
- 100mg
- Price
- $234
- Updated
- 2021/12/16
- Product number
- FB141404
- Product name
- 4-Bromo-6-hydroxyisoindolin-1-one
- Packaging
- 250mg
- Price
- $282.5
- Updated
- 2021/12/16
1H-Isoindol-1-one, 4-broMo-2,3-dihydro-6-hydroxy- Chemical Properties,Usage,Production
Uses
4-Bromo-6-hydroxyisoindoline-1-one is an organic intermediate that has been reported to be used in the preparation of tyrosine protease inhibitors.
Synthesis
808127-75-5
808127-76-6
Example 104B Synthesis of 4-bromo-6-hydroxy-1-isodihydroindolone: Example 104A (4-bromo-2,3-dihydro-6-methoxy-1H-isoindol-1-one, 100 mg, 0.41 mmol) was dissolved in dichloromethane (13 mL) to form a -78 °C suspension. At this temperature, a dichloromethane solution of 1 M BBr3 (1.2 mL, 1.2 mmol) was added dropwise and stirred at -78 °C for 1 h. The mixture was then brought to room temperature and continued to be stirred for 2 h. The reaction mixture was then stirred for 1 h at -78 °C. The reaction mixture was again treated with a dichloromethane solution (0.8 mL) of 1 M BBr3 and heated to reflux overnight. After completion of the reaction, it was cooled to room temperature and extracted by partitioning with water and ethyl acetate. The organic phase was dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated to afford the target product 4-bromo-2,3-dihydro-6-hydroxy-1H-isoindol-1-one (91 mg, 97% yield). Mass spectrum (ESI negative ion mode) m/z: 226, 228 ([M-H]-).
References
[1] Patent: US2005/26976, 2005, A1. Location in patent: Page/Page column 23
[2] Patent: WO2004/108672, 2004, A1. Location in patent: Page 51
1H-Isoindol-1-one, 4-broMo-2,3-dihydro-6-hydroxy- Preparation Products And Raw materials
Raw materials
Preparation Products
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