7-Bromo-5-fluoro-1,4-benzodiazine
- Product Name
- 7-Bromo-5-fluoro-1,4-benzodiazine
- CAS No.
- 1210048-05-7
- Chemical Name
- 7-Bromo-5-fluoro-1,4-benzodiazine
- Synonyms
- 7-Bromo-5-fluoroquinoxaline;Quinoxaline, 7-bromo-5-fluoro-;7-Bromo-5-fluoroquinoxaline 98%;7-Bromo-5-fluoro-1,4-benzodiazine
- CBNumber
- CB92560718
- Molecular Formula
- C8H4BrFN2
- Formula Weight
- 227.03
- MOL File
- 1210048-05-7.mol
7-Bromo-5-fluoro-1,4-benzodiazine Property
- Boiling point:
- 299.0±35.0 °C(Predicted)
- Density
- 1.741±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -1.77±0.30(Predicted)
- Appearance
- Light brown to brown Solid
- InChI
- InChI=1S/C8H4BrFN2/c9-5-3-6(10)8-7(4-5)11-1-2-12-8/h1-4H
- InChIKey
- MWNUJVQOZMVOAW-UHFFFAOYSA-N
- SMILES
- N1C2C(=C(F)C=C(Br)C=2)N=CC=1
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- PC49185
- Product name
- 7-Bromo-5-fluoroquinoxaline
- Purity
- 98%
- Packaging
- 100mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 3H32-B-Y8
- Product name
- 7-Bromo-5-fluoroquinoxaline
- Packaging
- 100mg
- Price
- $199
- Updated
- 2021/12/16
- Product number
- 3693DP
- Product name
- 7-Bromo-5-fluoroquinoxaline
- Packaging
- 250mg
- Price
- $263
- Updated
- 2021/12/16
- Product number
- PC49185
- Product name
- 7-Bromo-5-fluoroquinoxaline
- Purity
- 98%
- Packaging
- 250mg
- Price
- $286
- Updated
- 2021/12/16
- Product number
- 3H32-B-Y8
- Product name
- 7-Bromo-5-fluoroquinoxaline
- Packaging
- 250mg
- Price
- $316
- Updated
- 2021/12/16
7-Bromo-5-fluoro-1,4-benzodiazine Chemical Properties,Usage,Production
Synthesis
4845-50-5
517920-69-3
1210048-05-7
General procedure for the synthesis of 7-bromo-5-fluoroquinoxaline from 2,3-dihydroxy-1,4-dioxane and 5-bromo-3-fluorobenzene-1,2-diamine: 4.00 g (19.509 mmol) of 5-bromo-3-fluorobenzene-1,2-diamine was dissolved in 100 mL of ethanol and 2.42 g (19.509 mmol) of 2,3-dihydroxy-1,4 -dioxane. The reaction mixture was stirred at room temperature for 4 hours, followed by the addition of 2.42 g (19.509 mmol) of 2,3-dihydroxy-1,4-dioxane again. After continued stirring at room temperature for 24 h, the reaction mixture was concentrated using a rotary evaporator. The residue was purified by silica gel column chromatography with dichloromethane/methanol (30:1, v/v) as eluent. Finally, 3.60 g (80% yield) of the target product 7-bromo-5-fluoroquinoxaline was obtained.LC-MS (Method 1): retention time (R t) = 1.79 min; mass spectrum (EIpos): m/z = 227 [M + H]+.1H-NMR (400 MHz, DMSO-d6): δ (ppm) = 8.06 (dd, 1H), 8.24 ( t, 1H), 9.05 (d, 1H), 9.07 (d, 1H).
References
[1] Patent: WO2010/20363, 2010, A1. Location in patent: Page/Page column 117
7-Bromo-5-fluoro-1,4-benzodiazine Preparation Products And Raw materials
Raw materials
Preparation Products
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