Ro 01-6128

Product Name: Ro 01-6128
CAS No.: 302841-86-7
Chemical Name: Ro 01-6128
Synonyms: Ro 01-6128;Ro 01 6128,Ro 016128;ILSZPWZFQHSKLW-UHFFFAOYSA-N;Ethyl (2,2-diphenylacetyl)carbamate;ethyl N-[2,2-di(phenyl)acetyl]carbamate;(Diphenylacetyl)-carbamic acid ethy ester;Carbamic acid, N-(2,2-diphenylacetyl)-, ethyl ester
CBNumber: CB92561078
Molecular Formula: C17H17NO3
Formula Weight: 283.32
MOL File: 302841-86-7.mol

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Ro 01-6128 Property

Density: 1.156±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble to 100 mM in DMSO and to 100 mM in ethanol
form: Powder
pka: 7.97±0.46(Predicted)
color: White to light brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11991
Product name: Ro 01-6128
Purity: ≥98%
Packaging: 1mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 11991
Product name: Ro 01-6128
Purity: ≥98%
Packaging: 5mg
Price: $119
Updated: 2024/03/01

Cayman Chemical

Product number: 11991
Product name: Ro 01-6128
Purity: ≥98%
Packaging: 10mg
Price: $225
Updated: 2024/03/01

Tocris

Product number: 4348
Product name: Ro01-6128
Purity: ≥98%(HPLC)
Packaging: 10
Price: $111
Updated: 2021/12/16

Tocris

Product number: 4348
Product name: Ro01-6128
Purity: ≥98%(HPLC)
Packaging: 50
Price: $475
Updated: 2021/12/16

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Ro 01-6128 Chemical Properties,Usage,Production

Description

Glutamate, the major excitatory neurotransmitter in the CNS, activates eight known subtypes of metabotropic glutamate receptors (mGluRs). Highly selective modulators designed to act at allosteric sites on certain mGluR subtypes are being developed to preferentially regulate subtype-specific, glutamate-induced receptor activation. Ro 01-6128 is a positive allosteric modulator of mGluR1 that can potentiate glutamate-induced calcium release at rat mGluR1a with an EC₅₀ value of 104 nM. Ro 01-6128 activates ERK1/2 phosphorylation in the absence of exogenously added glutamate with an EC₅₀ value of 248 nM and potentiates glutamate-induced cAMP production with an EC₅₀ value of 21.5 μM.

Uses

Ro 01-6128 is an allosteric mGluR-1 activator.

IC 50

mGluR 1

References

[1] KAMONDANAI HEMSTAPAT. A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators.[J]. Molecular Pharmacology, 2006, 70 2: 616-626. DOI: 10.1124/mol.105.021857

Ro 01-6128 Preparation Products And Raw materials

Raw materials

Preparation Products

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Ro 01-6128 Suppliers

CHINA 33 United Kingdom 1 United States 7 Global 41

EMMX Biotechnology LLC

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TargetMol Chemicals Inc.

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MedBioPharmaceutical Technology Inc

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JinOu Biomedical (Nanjing) Co., Ltd.

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TargetMol Chemicals Inc.

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Shanghai Yifei Biotechnology Co. , Ltd.

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RD International Technology Co., Limited

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Cayman Chemical Company

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Biosynth Biological Technology (Suzhou) Co Ltd

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302841-86-7, Ro 01-6128Related Search:

Ro 01-6128

ILSZPWZFQHSKLW-UHFFFAOYSA-N

(Diphenylacetyl)-carbamic acid ethy ester

ethyl N-[2,2-di(phenyl)acetyl]carbamate

Ro 01 6128,Ro 016128

Carbamic acid, N-(2,2-diphenylacetyl)-, ethyl ester

Ethyl (2,2-diphenylacetyl)carbamate

302841-86-7