ChemicalBook > CAS DataBase List > Ro 01-6128

Ro 01-6128

Product Name
Ro 01-6128
CAS No.
302841-86-7
Chemical Name
Ro 01-6128
Synonyms
Ro 01-6128;Ro 01 6128,Ro 016128;ILSZPWZFQHSKLW-UHFFFAOYSA-N;Ethyl (2,2-diphenylacetyl)carbamate;ethyl N-[2,2-di(phenyl)acetyl]carbamate;(Diphenylacetyl)-carbamic acid ethy ester;Carbamic acid, N-(2,2-diphenylacetyl)-, ethyl ester
CBNumber
CB92561078
Molecular Formula
C17H17NO3
Formula Weight
283.32
MOL File
302841-86-7.mol
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Ro 01-6128 Property

Density 
1.156±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble to 100 mM in DMSO and to 100 mM in ethanol
form 
Powder
pka
7.97±0.46(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
11991
Product name
Ro 01-6128
Purity
≥98%
Packaging
1mg
Price
$25
Updated
2024/03/01
Cayman Chemical
Product number
11991
Product name
Ro 01-6128
Purity
≥98%
Packaging
5mg
Price
$119
Updated
2024/03/01
Cayman Chemical
Product number
11991
Product name
Ro 01-6128
Purity
≥98%
Packaging
10mg
Price
$225
Updated
2024/03/01
Tocris
Product number
4348
Product name
Ro01-6128
Purity
≥98%(HPLC)
Packaging
10
Price
$111
Updated
2021/12/16
Tocris
Product number
4348
Product name
Ro01-6128
Purity
≥98%(HPLC)
Packaging
50
Price
$475
Updated
2021/12/16
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Ro 01-6128 Chemical Properties,Usage,Production

Description

Glutamate, the major excitatory neurotransmitter in the CNS, activates eight known subtypes of metabotropic glutamate receptors (mGluRs). Highly selective modulators designed to act at allosteric sites on certain mGluR subtypes are being developed to preferentially regulate subtype-specific, glutamate-induced receptor activation. Ro 01-6128 is a positive allosteric modulator of mGluR1 that can potentiate glutamate-induced calcium release at rat mGluR1a with an EC50 value of 104 nM. Ro 01-6128 activates ERK1/2 phosphorylation in the absence of exogenously added glutamate with an EC50 value of 248 nM and potentiates glutamate-induced cAMP production with an EC50 value of 21.5 μM.

Uses

Ro 01-6128 is an allosteric mGluR-1 activator.

Ro 01-6128 Preparation Products And Raw materials

Raw materials

Preparation Products

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Ro 01-6128 Suppliers

China 28 United Kingdom 1 United States 6 Global 35
MQ (shanghai) Pharmaceuticals Co., Ltd.
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RD International Technology Co., Limited
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302841-86-7, Ro 01-6128Related Search:


  • Ro 01-6128
  • ILSZPWZFQHSKLW-UHFFFAOYSA-N
  • (Diphenylacetyl)-carbamic acid ethy ester
  • ethyl N-[2,2-di(phenyl)acetyl]carbamate
  • Ro 01 6128,Ro 016128
  • Carbamic acid, N-(2,2-diphenylacetyl)-, ethyl ester
  • Ethyl (2,2-diphenylacetyl)carbamate
  • 302841-86-7