2-Chloro-3-((2-Methoxyethyl)aMino)naphthalene-1,4-dione
- Product Name
- 2-Chloro-3-((2-Methoxyethyl)aMino)naphthalene-1,4-dione
- CAS No.
- 22272-22-6
- Chemical Name
- 2-Chloro-3-((2-Methoxyethyl)aMino)naphthalene-1,4-dione
- Synonyms
- NSC 91098;2-Chloro-3-(2-methoxyethylamino);2-Chloro-3-[(2-methoxyethyl)amino]-1,4-naphthoquinone;2-chloro-3-[(2-methoxyethyl)amino]-1,4-Naphthalenedione;2-Chloro-3-((2-Methoxyethyl)aMino)naphthalene-1,4-dione;1,4-Naphthalenedione, 2-chloro-3-[(2-methoxyethyl)amino]-;2-chloro-3-[(2-Methoxyethyl)aMino]-1,4-dihydronaphthalene-1,4-dione
- CBNumber
- CB92563153
- Molecular Formula
- C13H12ClNO3
- Formula Weight
- 265.69
- MOL File
- 22272-22-6.mol
2-Chloro-3-((2-Methoxyethyl)aMino)naphthalene-1,4-dione Property
- Boiling point:
- 373.4±42.0 °C(Predicted)
- Density
- 1.33
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- -0.19±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C349645
- Product name
- 2-Chloro-3-(2-methoxyethylamino)naphthalene-1,4-dione
- Packaging
- 25mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- C349645
- Product name
- 2-Chloro-3-(2-methoxyethylamino)naphthalene-1,4-dione
- Packaging
- 100mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- C349645
- Product name
- 2-Chloro-3-(2-methoxyethylamino)naphthalene-1,4-dione
- Packaging
- 250mg
- Price
- $235
- Updated
- 2021/12/16
- Product number
- FC141919
- Product name
- 2-Chloro-3-((2-methoxyethyl)amino)naphthalene-1,4-dione
- Packaging
- 500mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- HCH0319547
- Product name
- 2-CHLORO-3-(2-METHOXYETHYLAMINO)NAPHTHALENE-1,4-DIONE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $263.55
- Updated
- 2021/12/16
2-Chloro-3-((2-Methoxyethyl)aMino)naphthalene-1,4-dione Chemical Properties,Usage,Production
Uses
2-Chloro-3-(2-methoxyethylamino)naphthalene-1,4-dione
Synthesis
117-80-6
109-85-3
22272-22-6
GENERAL STEPS: 2-methoxyethylamine (12.5 mmol) was added slowly and dropwise to a stirring solution of 2,3-dichloro-1,4-naphthoquinone (10 mmol) and triethylamine (1 mL) in N,N-dimethylformamide (DMF, 20 mL) under ice bath conditions. After the color of the reaction mixture changed from light yellow to red, the ice bath was removed and the reaction continued to be stirred for 1 h at room temperature. Subsequently, the reaction solution was poured into 300 mL of water and an orange-red precipitate precipitated. The precipitate was collected by filtration, washed with cold water and dried to obtain the target product 2-chloro-3-((2-methoxyethyl)amino)naphthalene-1,4-dione. Yield: 96.1%; Appearance: orange powder; Melting point: 82-83 °C; 1H NMR (DMSO-d6, 400 MHz) δ: 7.98 (m, 2H), 7.75-7.87 (m, 2H), 7.25 (s, 1H), 3.92-3.94 (m, 2H), 3.57 (t, J = 5.7 Hz, 2H), 3.29- 3.38 (s, 3H); ESI-MS: m/z 266.1 [M + H]+, C13H12ClNO3 (MW = 265.1).
References
[1] European Journal of Medicinal Chemistry, 2018, vol. 144, p. 504 - 516
[2] MedChemComm, 2017, vol. 8, # 6, p. 1318 - 1321
[3] European Journal of Medicinal Chemistry, 2015, vol. 104, p. 42 - 56
[4] Patent: KR101761848, 2017, B1. Location in patent: Paragraph 0317-0320
[5] ChemMedChem, 2016, p. 1944 - 1955
2-Chloro-3-((2-Methoxyethyl)aMino)naphthalene-1,4-dione Preparation Products And Raw materials
Raw materials
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