ChemicalBook > CAS DataBase List > 3-CinnolinecarboxaMide, 4-aMino-8-(2-fluoro-6-Methoxyphenyl)-N-propyl-

3-CinnolinecarboxaMide, 4-aMino-8-(2-fluoro-6-Methoxyphenyl)-N-propyl-

Product Name: 3-CinnolinecarboxaMide, 4-aMino-8-(2-fluoro-6-Methoxyphenyl)-N-propyl-
CAS No.: 942437-37-8
Chemical Name: 3-CinnolinecarboxaMide, 4-aMino-8-(2-fluoro-6-Methoxyphenyl)-N-propyl-
Synonyms: AZD-7325;AZD-7325 ，S0164;AZD-7325 (AZD7325);AZD7325, 10 mM in DMSO;3-CinnolinecarboxaMide, 4-aMino-8-(2-fluoro-6-Methoxyphenyl)-N-propyl-;modulator,effect,inhibit,Cytochrome P450,Dravet,syndrome,Inhibitor,γ-Aminobutyric acid Receptor,CYPs,sedative,AZD7325,PAM,CYP1A2,Gamma-aminobutyric acid Receptor,anxiety,AZD 7325,GABA Receptor
CBNumber: CB92563380
Molecular Formula: C19H19FN4O2
Formula Weight: 354.38
MOL File: 942437-37-8.mol

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3-CinnolinecarboxaMide, 4-aMino-8-(2-fluoro-6-Methoxyphenyl)-N-propyl- Property

solubility: DMSO: soluble
form: A solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0034076
Product name: AZD7325
Purity: 98.88%
Packaging: 5mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-0034076
Product name: AZD7325
Purity: 98.88%
Packaging: 10mg
Price: $160
Updated: 2021/12/16

ChemScene

Product number: CS-0034076
Product name: AZD7325
Purity: 98.88%
Packaging: 50mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0034076
Product name: AZD7325
Purity: 98.88%
Packaging: 100mg
Price: $650
Updated: 2021/12/16

DC Chemicals

Product number: DC20731
Product name: AZD-7325
Purity: >98%
Packaging: 1g
Price: $1950
Updated: 2021/12/16

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3-CinnolinecarboxaMide, 4-aMino-8-(2-fluoro-6-Methoxyphenyl)-N-propyl- Chemical Properties,Usage,Production

Uses

AZD7325 is a potent and orally active partial selective PAM of GABAAα2 and Aα3 receptor (Ki=0.3 and 1.3 nM, respectively), and has less antagonistic efficacy at the Aα1?and Aα5?receptor subtypes[1][4]. AZD7325 is a moderate?CYP1A2?and a potent?CYP3A4?inducer in vitro[2]. AZD7325 has the potential for the investigation of anxiety and dravet syndrome[3]. PAM: positive allosteric modulator.

in vivo

AZD7325 (oral administration; 10, 17.8 or 31.6 mg/kg; 30 minutes before the induction of hyperthermia) attenuates hyperthermia-induced seizures, shows median thresholds in the treatment groups of 42.8°C for 10 mg/kg, 43.3°C for 17.8 mg/kg, and 43.4°C for 31.6 mg/kg compares to 42.2°C in vehicle group^[3].

Animal Model:	Male and female P18 - P20 F1.Scn1a^+/- mice^[3]
Dosage:	10, 17.8 or 31.6 mg/kg
Administration:	Oral administration; 30 minutes before the induction of hyperthermia
Result:	Attenuated hyperthermia-induced seizures in F1.Scn1a^+/- mice with no sedative effect.

IC 50

CYP1A2; CYP3A4

References

[1] Chen X, et al. The central nervous system effects of the partial GABA-Aα2,3 -selective receptor modulator AZD7325 in comparison with lorazepam in healthy males.Br J Clin Pharmacol. 2014 Dec;78(6):1298-314. DOI:10.1111/bcp.12413
[2] Zhou D, et al. A clinical study to assess CYP1A2 and CYP3A4 induction by AZD7325, a selective GABA(A) receptor modulator - an in vitro and in vivo comparison.Br J Clin Pharmacol.?2012?Jul;74(1):98-108. DOI:10.1111/j.1365-2125.2011.04155.x
[3] Nomura T, et al. Potentiating α2?subunit containing perisomatic GABAA?receptors protects against seizures in a mouse model of Dravet syndrome.J Physiol.?2019 Aug;597(16):4293-4307. DOI:10.1113/JP277651
[4] AZD7325,Mechanism of action: Gamma-aminobutyric acid receptor A alpha 2 & 3 (GABAAα2,3) positive modulator

3-CinnolinecarboxaMide, 4-aMino-8-(2-fluoro-6-Methoxyphenyl)-N-propyl- Preparation Products And Raw materials

Raw materials

Preparation Products

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942437-37-8, 3-CinnolinecarboxaMide, 4-aMino-8-(2-fluoro-6-Methoxyphenyl)-N-propyl-Related Search:

AZD-7325 (AZD7325)

3-CinnolinecarboxaMide, 4-aMino-8-(2-fluoro-6-Methoxyphenyl)-N-propyl-

AZD-7325

modulator,effect,inhibit,Cytochrome P450,Dravet,syndrome,Inhibitor,γ-Aminobutyric acid Receptor,CYPs,sedative,AZD7325,PAM,CYP1A2,Gamma-aminobutyric acid Receptor,anxiety,AZD 7325,GABA Receptor

AZD7325, 10 mM in DMSO

AZD-7325 ，S0164

942437-37-8

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