2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole
- Product Name
- 2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole
- CAS No.
- 1218791-01-5
- Chemical Name
- 2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole
- Synonyms
- 2-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)thiazole;2-Methylthiazole-5-boronic acid, pinacol ester;2-methylthiazol-5-ylboronic acid pinacol ester;2-Methylthiazole-5-boronic acid, pinacol ester 97%;2-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole;2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thia...;Thiazole, 2-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-;5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methyl-1,3-thiazole;2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole;2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole - [M81771]
- CBNumber
- CB92564165
- Molecular Formula
- C10H16BNO2S
- Formula Weight
- 225.12
- MOL File
- 1218791-01-5.mol
2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole Property
- Boiling point:
- 312.1±15.0 °C(Predicted)
- Density
- 1.10±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 3.29±0.10(Predicted)
- form
- low melting solid
- color
- White to off-white
- InChI
- InChI=1S/C10H16BNO2S/c1-7-12-6-8(15-7)11-13-9(2,3)10(4,5)14-11/h6H,1-5H3
- InChIKey
- QXMZPGMBRRZCDV-UHFFFAOYSA-N
- SMILES
- S1C(B2OC(C)(C)C(C)(C)O2)=CN=C1C
Safety
- HS Code
- 2934100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B486630
- Product name
- 2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 283704
- Product name
- 2-Methylthiazole-5-boronic acid pinacol ester
- Packaging
- 100mg
- Price
- $602
- Updated
- 2021/12/16
- Product number
- 127905
- Product name
- 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methyl-1,3-thiazole
- Purity
- 97%
- Packaging
- 1g
- Price
- $1505
- Updated
- 2021/12/16
- Product number
- X1746
- Product name
- 2-Methylthiazole-5-boronicacidpinacolester
- Packaging
- 25g
- Price
- $1624
- Updated
- 2021/12/16
- Product number
- OR361488
- Product name
- 2-Methylthiazole-5-boronicacid,pinacolester
- Purity
- 97%
- Packaging
- 250mg
- Price
- $112
- Updated
- 2021/12/16
2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole Chemical Properties,Usage,Production
Synthesis
57268-16-3
61676-62-8
1218791-01-5
5-Bromo-2-methylthiazole (2 g, 11.23 mmol) was dissolved in 70 mL of anhydrous tetrahydrofuran and cooled to -78 °C. A hexane solution (5.6 mL) of 2.4 M n-butyllithium was added slowly and dropwise under nitrogen protection, keeping the temperature at -78 °C. After stirring the reaction for 30 minutes, 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (2.5 g, 13.44 mmol) was added. The reaction was continued with stirring at -78 °C for 1.5 hours. Upon completion of the reaction, the reaction mixture was slowly warmed to room temperature. The reaction was quenched with a mixture of 10 mL of saturated aqueous ammonium chloride and 10 mL of water. The organic phase was separated by adding 50 mL of ethyl acetate for extraction. The aqueous phase was extracted once more with 30 mL of ethyl acetate. The organic phases were combined, dried with anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure and the resulting residue was purified by silica gel column chromatography (elution system B) to afford the target product 2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole (1.6 g, 64% yield) as a light yellow oil. Mass spectrum (ESI) m/z: 226.1 [M + H]+.
References
[1] Patent: EP3312184, 2018, A1. Location in patent: Paragraph 0101; 0144; 0145
2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole Preparation Products And Raw materials
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