ChemicalBook > CAS DataBase List > N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-aMine

N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-aMine

Product Name
N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-aMine
CAS No.
413611-93-5
Chemical Name
N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-aMine
Synonyms
10074-g;10074-G5;10074G5;10074 G5;c-Myc Inhibitor II;10074-G5 >=98% (HPLC);c-Myc Inhibitor II - CAS 413611-93-5 - Calbiochem;N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-aMine;Biphenyl-2-yl-(7-nitrobenzo[1,2,5]oxadiazol-4-yl)amine;N-(2-Biphenylyl)-4-amino-7-nitrobenzo[c][1,2,5]oxadiazole;N-[1,1′-Biphenyl-2-yl]-7-nitro-2,1,3-Benzoxadiazol-4-amine
CBNumber
CB92582970
Molecular Formula
C18H12N4O3
Formula Weight
332.31
MOL File
413611-93-5.mol
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N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-aMine Property

Boiling point:
538.6±60.0 °C(Predicted)
Density 
1.408±0.06 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: >10mg/mL
pka
-2.06±0.50(Predicted)
form 
powder
color 
red
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Safety

Hazard Codes 
T
Risk Statements 
25-36/37/38
Safety Statements 
26-45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G3798
Product name
10074-G5
Purity
≥98% (HPLC)
Packaging
5mg
Price
$120
Updated
2024/03/01
Sigma-Aldrich
Product number
475957
Product name
c-Myc Inhibitor II
Packaging
10mg
Price
$126
Updated
2023/06/20
Cayman Chemical
Product number
17408
Product name
10074-G5
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17408
Product name
10074-G5
Purity
≥98%
Packaging
5mg
Price
$70
Updated
2024/03/01
Sigma-Aldrich
Product number
G3798
Product name
10074-G5
Purity
≥98% (HPLC)
Packaging
25mg
Price
$492
Updated
2024/03/01
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N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-aMine Chemical Properties,Usage,Production

Uses

N-[1,1''-Biphenyl]-2-yl-7-nitro-2,1,3-benzoxadiazol-4-amine is a c-Myc inhibitor that suppresses its transcriptional activity.c-Myc is an oncoprotein often found overexpressed in various tumors.

General Description

A cell-permeable benzoxadiazole compound that is shown to preferentially disrupt the interactions of c-Myc-Max, Mad1-Max, and Myf5-HEB, over those of 31 other pairs of HLH-, ZIP-, and HLH-ZIP-containing proteins. Similarly to 10058-F4 (Cat. No. 475956), 10074-G5 is shown to selectively inhibit the c-Myc-dependent growth of rat fibroblast cell line TGR1 and effectively suppress c-Myc-dependent transcription activity. Binding studies using various mutated and truncated c-Myc constructs reveal that 10074-G5 targets c-Myc helix-1 region between aa 363 and 381 (KD = 4.4 μM), while 10058-F4 interaction site is located within aa residues 402 through 412 (KD = 13 μM).

Biological Activity

10074-g5 is a c-myc inhibitor [1].c-myc is a bhlh-zip transcription factor involved in cell cycle progression, cellular growth and metabolism, differentiation, and apoptosis. overexpression of c-myc has been identified in numerous cancers, including prostate, pancreatic, lung, breast, and colon cancers, b-cell lymphoma, and leukemias. alterations in c-myc have been associated with cancer aggressiveness and poor treatment prognosis. inhibition of c-myc is an attractive pharmacological approach in the development of new anticancer treatments. inactivation of c-myc rapidly results in cell-cycle arrest, apoptosis, tumor vascular degeneration, redifferentiation of tumor cells, and ultimately tumor regression [1].the ic50 values of 10074-g5 against daudi cells and hl-60 cells were 15.6 ± 1.5 μm and 13.5 ± 2.1 μm, respectively. 10074-g5 (10 μm) inhibited c-myc/max dimerization and decreased total c-myc protein expression. in c.b-17 scid mice bearing daudi xenografts, treatment with 10074-g5, (20 mg/kg i.v., for 10 consecutive days) significantly inhibited tumor growth with no effects on body weight.

Biochem/physiol Actions

10074-G5 is a c-Myc/Max interaction inhibitor. The c-Myc oncoprotein and its partner Max are intrinsically disordered (ID) monomers that undergo coupled folding and binding upon heterodimerization. 10074-G5, similarly to 10058-F4 (#F3680), specifically inhibits this interaction by binding to c-Myc, thus preventing C-Myc specific DNA binding and target genes regulation. 10074-G5 (2.8 microM) is slightly more potent that 10058-F4 (5.2 microM). It was discovered that 10074-G5 binds to a different specific binding site (region) of C-Myc than 10054-F4. Thus, the compound may become desirable for probing different interactions.

References

[1] clausen d m, guo j, parise r a, et al. in vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-g5, a novel small-molecule inhibitor of c-myc/max dimerization[j]. journal of pharmacology and experimental therapeutics, 2010, 335(3): 715-727.

N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-aMine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-aMine Suppliers

China 61 United States 9 Global 70
Shanghai Boyle Chemical Co., Ltd.
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021-50182298 021-50180596
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+86-21-57758967
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sales@boylechem.com
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China
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Tianjin heowns Biochemical Technology Co., Ltd.
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400 638 7771
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sales@heowns.com
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Sigma-Aldrich
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orderCN@merckgroup.com
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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Struchem Co., Ltd.
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0512-0512-63009836 15365350169
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Target molecule Corp.
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Tianjin Kailiqi Biotechnology Co., Ltd.
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15076683720
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022-23754520
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Shanghai Chaolan Chemical Technology Center
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QQ:65489617 15618227136
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21-5161 9052
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info@SuperLan-chem.com
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Beijing Solarbio Science & Tecnology Co., Ltd.
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010-50973130 4009686088
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View Lastest Price from N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-aMine manufacturers

Career Henan Chemical Co
Product
N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-aMine 413611-93-5
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
20kg
Release date
2019-12-23

413611-93-5, N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-aMineRelated Search:


  • N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-aMine
  • 10074-G5
  • Biphenyl-2-yl-(7-nitrobenzo[1,2,5]oxadiazol-4-yl)amine
  • N-[1,1′-Biphenyl-2-yl]-7-nitro-2,1,3-Benzoxadiazol-4-amine
  • c-Myc Inhibitor II
  • c-Myc Inhibitor II - CAS 413611-93-5 - Calbiochem
  • 10074G5;10074 G5
  • 10074-g
  • 2,1,3-Benzoxadiazol-4-amine, N-[1,1'-biphenyl]-2-yl-7-nitro-
  • 10074-G5 >=98% (HPLC)
  • N-([1,1'-Biphenyl]-2-yl)-7-nitrobenzo[c][1,2,5]oxadiazol-4-amine
  • 10074G5,Inhibitor,10074 G5,10074-G-5,10074-G5,c-Myc,Autophagy,inhibit,Myc
  • N-(2-Biphenylyl)-4-amino-7-nitrobenzo[c][1,2,5]oxadiazole
  • N-([1,1'-Biphenyl]-2-yl)-7-nitrobenzo[c][1,2,5]oxadiazol-4-amine
  • 413611-93-5