(e)-n-(2-(3,4-dihydroxyphenyl)ethyl)-3-(4-hydroxyphenyl)-2-propenaMide

Uses

Product Name: (e)-n-(2-(3,4-dihydroxyphenyl)ethyl)-3-(4-hydroxyphenyl)-2-propenaMide
CAS No.: 103188-46-1
Chemical Name: (e)-n-(2-(3,4-dihydroxyphenyl)ethyl)-3-(4-hydroxyphenyl)-2-propenaMide
Synonyms: Coumaryldopamine;N-CouMaroyldopaMine;trans-4-couMaroyldopaMine;N-(3,4-dihydroxyphenethyl)-3-(4-hydroxyphenyl)acrylamide;(E)-N-(3,4-Dihydroxyphenethyl)-3-(4-hydroxyphenyl)acrylamide;(2E)-N-[2-(3,4-Dihydroxyphenyl)ethyl]-3-(4-hydroxyphenyl)acrylaMide;(e)-n-(2-(3,4-dihydroxyphenyl)ethyl)-3-(4-hydroxyphenyl)-2-propenaMide;(E)-N-[2-(3,4-dihydroxyphenyl)ethyl]-3-(4-hydroxyphenyl)prop-2-enamide;(e)-n-(2-(3,4-dihydroxyphenyi)ethyl)-3-(4-hydroxyphenyl)-2-propenaMide;(2E)-N-[2-(3,4-dihydroxyphenyl)ethyl]-3-(4-hydroxyphenyl)prop-2-enamide
CBNumber: CB92583063
Molecular Formula: C17H17NO4
Formula Weight: 299.32
MOL File: 103188-46-1.mol

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(e)-n-(2-(3,4-dihydroxyphenyl)ethyl)-3-(4-hydroxyphenyl)-2-propenaMide Property

Boiling point:: 636.8±55.0 °C(Predicted)
Density: 1.381
storage temp.: Inert atmosphere,Room Temperature
pka: 9.77±0.26(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CHM0392173
Product name: (E)-N-(3,4-DIHYDROXYPHENETHYL)-3-(4-HYDROXYPHENYL)ACRYLAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $503.45
Updated: 2021/12/16

AK Scientific

Product number: 0757AA
Product name: (E)-N-(3,4-Dihydroxyphenethyl)-3-(4-hydroxyphenyl)acrylamide
Packaging: 1g
Price: $1103
Updated: 2021/12/16

Alichem

Product number: 103188461
Product name: (E)-N-(3,4-Dihydroxyphenethyl)-3-(4-hydroxyphenyl)acrylamide
Packaging: 1g
Price: $764.4
Updated: 2021/12/16

Crysdot

Product number: CD12185419
Product name: (E)-N-(3,4-Dihydroxyphenethyl)-3-(4-hydroxyphenyl)acrylamide
Purity: 95+%
Packaging: 1g
Price: $772
Updated: 2021/12/16

Alichem

Product number: 103188461
Product name: (E)-N-(3,4-Dihydroxyphenethyl)-3-(4-hydroxyphenyl)acrylamide
Packaging: 100mg
Price: $206.7
Updated: 2021/12/16

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(e)-n-(2-(3,4-dihydroxyphenyl)ethyl)-3-(4-hydroxyphenyl)-2-propenaMide Chemical Properties,Usage,Production

Uses

N-Coumaroyl Dopamine inhibits the synthesis of prostaglandins and leukotrienes in vitro.

Synthesis

3943-97-3

645-31-8

106005-97-4

General procedure for the synthesis of N-coumaroyldopamine (CAS:106005-97-4) from methyl 4-hydroxycinnamate and 2-(3,4-dihydroxyphenyl)ethylamine: 14.2 g of dopamine hydrobromide, 9.0 g of methyl p-hydroxycinnamate, 5.1 g of sodium bicarbonate, and 50 mL of N-methyl pyrrolidone were added to 100 mL of a four-necked round-bottomed flask. The reaction mixture was heated to 160 °C under nitrogen protection and maintained for 12 h. The progress of the reaction was monitored by TLC. Upon completion of the reaction, 200 mL of water was added to the mixture and extracted with ethyl acetate (100 mL x 3). The organic phases were combined and washed sequentially with saturated brine (100 mL × 2) and 1N dilute hydrochloric acid (100 mL × 2). The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated to give 28.0 g of slurry. To the slurry was added 20 mL of petroleum ether and 2 mL of ethyl acetate and heated to reflux for 30 min. After cooling, it was allowed to stand and the upper solution was poured out. To the remaining slurry, 10 mL of anhydrous ethanol was added, stirred for 30 min, filtered and dried to give 10.2 g of white solid product. The product was identified as N-coumaroyldopamine by NMR. This method can obtain a high purity product without column chromatography purification, and the yield can be up to 67%.

References

[1] Patent: CN105777573, 2016, A. Location in patent: Paragraph 0010; 0015-0016

(e)-n-(2-(3,4-dihydroxyphenyl)ethyl)-3-(4-hydroxyphenyl)-2-propenaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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(e)-n-(2-(3,4-dihydroxyphenyl)ethyl)-3-(4-hydroxyphenyl)-2-propenaMide Suppliers

China 43 China Hong Kong 1 India 1 United States 1 Global 46

ChemFuture PharmaTech (Jiangsu) Ltd

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ShangHai Siyan Biological Technology Co., Ltd.

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Raw material medicin reagent co.,Ltd

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View Lastest Price from (e)-n-(2-(3,4-dihydroxyphenyl)ethyl)-3-(4-hydroxyphenyl)-2-propenaMide manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: N-Coumaroyldopamine 103188-46-1
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-11-29

Dingwang Technology (Wuhan) Co., Ltd.

Product: (e)-n-(2-(3,4-dihydroxyphenyl)ethyl)-3-(4-hydroxyphenyl)-2-propenaMide 103188-46-1
Price: US $0.00/g
Min. Order: 5g
Purity: 98%
Supply Ability: 500kg
Release date: 2023-02-08

Career Henan Chemical Co

Product: (e)-n-(2-(3,4-dihydroxyphenyl)ethyl)-3-(4-hydroxyphenyl)-2-propenaMide 103188-46-1
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20tons
Release date: 2018-07-24

103188-46-1, (e)-n-(2-(3,4-dihydroxyphenyl)ethyl)-3-(4-hydroxyphenyl)-2-propenaMideRelated Search:

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(e)-n-(2-(3,4-dihydroxyphenyl)ethyl)-3-(4-hydroxyphenyl)-2-propenaMide

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(2E)-N-[2-(3,4-Dihydroxyphenyl)ethyl]-3-(4-hydroxyphenyl)acrylaMide

N-CouMaroyldopaMine

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N-(3,4-dihydroxyphenethyl)-3-(4-hydroxyphenyl)acrylamide

(E)-N-[2-(3,4-dihydroxyphenyl)ethyl]-3-(4-hydroxyphenyl)prop-2-enamide

(E)-N-(3,4-Dihydroxyphenethyl)-3-(4-hydroxyphenyl)acrylamide

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2-Propenamide, N-[2-(3,4-dihydroxyphenyl)ethyl]-3-(4-hydroxyphenyl)-, (2E)-

(E) -N - (2- (3, 4-dihydroxy phenyl) ethyl) -3- (4-hydroxy phenyl) -2-acrylamide

Tianfu Chem 103188-46-1 (e)-n-(2-(3,4-dihydroxyphenyl)ethyl)-3-(4-hydroxyphenyl)-2-propenaMide

(e)-n-(2-(3,4-dihydroxyphenyi)ethyl)-3-(4-hydroxyphenyl)-2-propenaMide

103188-46-1