3,5 - DibroMo - 2,4 - diMethylpyridine

Product Name: 3,5 - DibroMo - 2,4 - diMethylpyridine
CAS No.: 29976-20-3
Chemical Name: 3,5 - DibroMo - 2,4 - diMethylpyridine
Synonyms: Pyridine, 3,5-dibromo-2,4-dimethyl-;3,5 - DibroMo - 2,4 - diMethylpyridine
CBNumber: CB92583098
Molecular Formula: C7H7Br2N
Formula Weight: 264.95
MOL File: 29976-20-3.mol

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3,5 - DibroMo - 2,4 - diMethylpyridine Property

Melting point:: 32-33 °C
Boiling point:: 253.9±35.0 °C(Predicted)
Density: 1.795±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 1.89±0.28(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 3091AB
Product name: 3,5-Dibromo-2,4-dimethylpyridine
Packaging: 100mg
Price: $145
Updated: 2021/12/16

AK Scientific

Product number: 3091AB
Product name: 3,5-Dibromo-2,4-dimethylpyridine
Packaging: 250mg
Price: $201
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0364197
Product name: 3,5-DIBROMO-2,4-DIMETHYLPYRIDINE
Purity: 95.00%
Packaging: 5MG
Price: $502.08
Updated: 2021/12/16

Aaron Chemicals

Product number: AR00BGTS
Product name: 3,5-DibroMo-2,4-diMethylpyridine
Purity: 98%
Packaging: 100mg
Price: $54
Updated: 2021/12/16

Aaron Chemicals

Product number: AR00BGTS
Product name: 3,5-DibroMo-2,4-diMethylpyridine
Purity: 98%
Packaging: 250mg
Price: $78
Updated: 2021/12/16

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3,5 - DibroMo - 2,4 - diMethylpyridine Chemical Properties,Usage,Production

Synthesis

108-47-4

27063-92-9

29976-20-3

27063-93-0

GENERAL STEPS: Dissolve 2,4-dimethylpyridine (5.39 mL, 46.7 mmol, 1 eq.) in bromide (50 mL) containing 20% free SO3 at 0 °C with stirring. A high efficiency reflux condenser was installed and heated to 165°C in an oil bath. Bromine (4.30 mL, 83.4 mmol, 0.9 eq.) was added in batches over a period of 5 hours, maintaining the temperature at 155-175 °C and stirring for 20 hours. After completion of the reaction, it was cooled to room temperature and the reaction solution was poured into crushed ice (200 g) and stirred for 1 hour. The solution was neutralized with solid Na2CO3 vesicles to an orange solution, diluted with water and extracted with EtOAc (2 x 250 mL). The organic layers were combined, dried with Na2SO4 and concentrated in vacuum. The crude product was purified by automated fast column chromatography (Biotage KP-Sil SNAP 340g column, 0-15% EtOAc/hexane) and dried under vacuum to give three brominated products: 3,5-dibromo-2,4-dimethylpyridine (8), 5-bromo-2,4-dimethylpyridine (9) and 3-bromo-2,4-dimethylpyridine (10). 3,5-Dibromo-2,4-dimethylpyridine (8) is a white solid (1.48 g, 12%) with a melting point of 28-30 °C. 1H NMR (400 MHz, CDCl3) δ 2.54 (s, 3H, CH3), 2.61 (s, 3H, CH3), 8.41 (s, 1H, pyHortho); 13C NMR (100 MHz, CDCl3) δ 23.8 (CH3), 25.7 (CH3), 120.3 (ArC), 124.4 (ArC), 146.4 (ArC), 148.5 (ArCH), 156.5 (ArC); IR νmax (film)/cm1 3045, 2998, 2956, 2921, 1558, 1433, 1376, 1349, 1232, 1376, 1349, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232 1376, 1349, 1232, 1049, 993, 928, 783; HRMS (ESI+) m/z calcd for C7H8Br2N [M+H]+ 263.9018, found 263.9027. 5-Bromo-2,4-dimethylpyridine (9) was a colorless oil (1.89 g, 22%).1H NMR (400 MHz, CDCl3) δ 2.32 (s, 3H, CH3), 2.44 (s, 3H, CH3), 7.00 (s, 1H, pyHortho), 8.47 (s, 1H, pyHmeta); 13C NMR ( 100 MHz, CDCl3) δ 22.1 (CH3), 23.6 (CH3), 120.4 (ArC), 125.5 (ArCH), 146.7 (ArC), 150.5 (ArCH), 157.0 (ArC); IR νmax (film)/cm1 2985, 2957, 2924, 2854, 1592, 1461, 1377 1592, 1461, 1377, 1353, 1289, 1177, 1032; HRMS (ESI+) m/z calcd for C7H9BrN [M+H]+ 185.9913, found 185.9918. 3-Bromo-2,4-dimethylpyridine (10) was a colorless oil (3.04 g, 35%).1H NMR (400 MHz, CDCl3) δ 2.33 (s, 3H, CH3), 2.61 (s, 3H, CH3), 6.91 (d, J = 5.0 Hz, 1H, pyHmeta), 8.18 (d, J = 5.0 Hz, 1H, 2995, 2958, 2922, 1585, 1437, 1389, 1123, 1024, 916, 825; HRMS (ESI+) m/z calcd for C7H9BrN [M+H]+ 185.9913, found 185.9917.

References

[1] Zeitschrift fuer Chemie (Stuttgart, Germany), 1988, vol. 28, # 2, p. 59 - 60
[2] Patent: WO2010/43866, 2010, A2. Location in patent: Page/Page column 48; 87-88
[3] Organic and Biomolecular Chemistry, 2011, vol. 9, # 1, p. 127 - 135

3,5 - DibroMo - 2,4 - diMethylpyridine Preparation Products And Raw materials

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Preparation Products

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View Lastest Price from 3,5 - DibroMo - 2,4 - diMethylpyridine manufacturers

Career Henan Chemical Co

Product: 3,5 - DibroMo - 2,4 - diMethylpyridine 29976-20-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-20

29976-20-3, 3,5 - DibroMo - 2,4 - diMethylpyridineRelated Search:

3,5 - DibroMo - 2,4 - diMethylpyridine

Pyridine, 3,5-dibromo-2,4-dimethyl-

29976-20-3