ChemicalBook > CAS DataBase List > (1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile

(1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile

Product Name
(1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile
CAS No.
848344-36-5
Chemical Name
(1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile
Synonyms
CS-401;AS 602801;Bentamapimod;AS 602801 (BentaMapiMod);Bentamapimod (AS 602801);AS-602801;BENTAMAPIMOD;AS602801;AS-602801,inhibit,JNK,Inhibitor,Bentamapimod,AS602801;2-Benzothiazoleacetonitrile, α-[2-[[4-(4-morpholinylmethyl)phenyl]methoxy]-4-pyrimidinyl]-;2-(Benzo[d]thiazol-2-yl)-2-(2-((4-(morpholinomethyl)benzyl)oxy)pyrimidin-4-yl)acetonitrile;(1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile
CBNumber
CB92589641
Molecular Formula
C25H23N5O2S
Formula Weight
457.55
MOL File
848344-36-5.mol
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(1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile Property

Boiling point:
666.5±65.0 °C(Predicted)
Density 
1.326
storage temp. 
2-8°C
solubility 
insoluble in H2O; insoluble in EtOH; ≥11.45 mg/mL in DMSO
form 
solid
pka
6.47±0.10(Predicted)
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3358
Product name
AS602801
Purity
≥98% (HPLC)
Packaging
5MG
Price
$81.2
Updated
2024/03/01
Sigma-Aldrich
Product number
SML3358
Product name
AS602801
Purity
≥98% (HPLC)
Packaging
25MG
Price
$327
Updated
2024/03/01
Cayman Chemical
Product number
21482
Product name
Bentamapimod
Purity
≥98%
Packaging
1mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
21482
Product name
Bentamapimod
Purity
≥98%
Packaging
5mg
Price
$177
Updated
2024/03/01
Cayman Chemical
Product number
21482
Product name
Bentamapimod
Purity
≥98%
Packaging
10mg
Price
$254
Updated
2024/03/01
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(1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile Chemical Properties,Usage,Production

Description

Bentamapimod is an orally bioavailable inhibitor of Jun kinases (JNKs), with IC50 values for JNK1, JNK2, and JNK3 of 80, 90, and 230 nM, respectively. It is selective for JNKs over a panel of 25 related kinases. Bentamapimod induces regression of endometriotic lesions without suppressing estrogen action in animal models of endometriosis. It blocks proliferation and induces apoptosis of T cells in vitro and inhibits cancer stem cell survival, self-renewal, and tumor-initiating capacity in vitro and in mice.

Uses

Bentamapimod is a potent and selective JNK inhibitor with therapeutic potential in MS (multiple sclerosis) and fibrosis. Studies show that Bentamapimod also reduced induced endometriosis in baboons.

in vitro

as602801 blocked t-lymphocyte proliferation and induced apoptosis. in rrms cd4t and cd8t cells, as602801 induced apoptosis genes and expression of surface markers, while in rrms cd11bt cells it induced expression of innate immunity receptors and co-stimulatory molecules [1].

in vivo

as602801, the best jnk inhibitors identified so far, were currently evaluated in preclinical studies, based on preliminary promising results in animal model of auto-immune diseases and neuronal apoptosis [1].

References

[1] ferrandi c, richard f, tavano p, hauben e, barbié v, gotteland jp, greco b, fortunato m, mariani mf, furlan r, comi g, martino g, zaratin pf. characterization of immune cell subsets during the active phase of multiple sclerosis reveals disease and c-jun n-terminal kinase pathway biomarkers. mult scler. 2011;17(1):43-56.

(1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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(1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile Suppliers

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848344-36-5, (1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrileRelated Search:

H-TYR-LEU-OH

  • (1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile
  • AS 602801
  • Bentamapimod
  • AS 602801 (BentaMapiMod)
  • (1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile AS602801(Bentamapimod)
  • Bentamapimod (AS 602801)
  • CS-401
  • 2-(1,3-benzothiazol-2-yl)-2-[2-[[4-(morpholin-4-ylmethyl)phenyl]methoxy]pyrimidin-4-yl]acetonitrile
  • AS-602801;BENTAMAPIMOD;AS602801
  • 2-Benzothiazoleacetonitrile, α-[2-[[4-(4-morpholinylmethyl)phenyl]methoxy]-4-pyrimidinyl]-
  • AS-602801,inhibit,JNK,Inhibitor,Bentamapimod,AS602801
  • 2-(Benzo[d]thiazol-2-yl)-2-(2-((4-(morpholinomethyl)benzyl)oxy)pyrimidin-4-yl)acetonitrile
  • 848344-36-5
  • Inhibitors