(±)10-HDoHE

Product Name: (±)10-HDoHE
CAS No.: 90780-50-0
Chemical Name: (±)10-HDoHE
Synonyms: (±)10-HDHA;DDCYKEYDTGCKAS-SKSHMZPZSA-N;4,7,11,13,16,19-Docosahexaenoic acid, 10-hydroxy-, (4Z,7Z,11E,13Z,16Z,19Z)-
CBNumber: CB92589777
Molecular Formula: C22H32O3
Formula Weight: 344.49
MOL File: 90780-50-0.mol

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(±)10-HDoHE Property

Boiling point:: 511.2±50.0 °C(Predicted)
Density: 0.995±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml
pka: 4.58±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 33400
Product name: (±)10-HDHA
Purity: ≥98%
Packaging: 25μg
Price: $77
Updated: 2024/03/01

Cayman Chemical

Product number: 33400
Product name: (±)10-HDHA
Purity: ≥98%
Packaging: 50μg
Price: $144
Updated: 2024/03/01

Cayman Chemical

Product number: 33400
Product name: (±)10-HDHA
Purity: ≥98%
Packaging: 100μg
Price: $273
Updated: 2024/03/01

Cayman Chemical

Product number: 33400
Product name: (±)10-HDHA
Purity: ≥98%
Packaging: 250μg
Price: $602
Updated: 2024/03/01

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(±)10-HDoHE Chemical Properties,Usage,Production

Description

(±)10-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.^1,2 It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.^3,4,5 (±)10-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.

References

1. VanRollins, M., and Murphy, R.C. Autooxidation of docosahexaenoic acid: Analysis of ten isomers of hydroxydocosahexaenoate J. Lipid Res. 25(5),507-517(1984).
2. Reynaud, D., Thickitt, C.P., and Pace-Asciak, C.R. Facile preparation and structural determination of monohydroxy derivatives of docosahexaenoic acid (HDoHE) by α-tocopherol-directed autoxidation Anal. Biochem. 214(1),165-170(1993).
3. VanRollins, M., Baker, R.C., Sprecher, H., et al. Oxidation of docosahexaenoic acid by rat liver microsomes J. Biol. Chem. 259(9),5776-5783(1984).
4. Yamane, M., Abe, A., and Yamane, S. High-performance liquid chromatography-thermospray mass spectrometry of epoxy polyunsaturated fatty acids and epoxyhydroxy polyunsaturated fatty acids from an incubation mixture of rat tissue homogenate J. Chromatogr. 652(2),123-136(1994).
5. Kim, H.Y., Karanian, J.W., Shingu, T., et al. Sterochemical analysis of hydroxylated docosahexaenoates produced by human platelets and rat brain homogenate Prostaglandins 40(5),473-490(1990).

(±)10-HDoHE Preparation Products And Raw materials

Raw materials

Preparation Products

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(±)10-HDoHE Suppliers

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90780-50-0, (±)10-HDoHERelated Search:

(±)10-HDHA

DDCYKEYDTGCKAS-SKSHMZPZSA-N

4,7,11,13,16,19-Docosahexaenoic acid, 10-hydroxy-, (4Z,7Z,11E,13Z,16Z,19Z)-

90780-50-0