ChemicalBook > CAS DataBase List > 1-NBD-decanoyl-2-decanoyl-sn-Glycerol

1-NBD-decanoyl-2-decanoyl-sn-Glycerol

Product Name
1-NBD-decanoyl-2-decanoyl-sn-Glycerol
CAS No.
2309189-98-6
Chemical Name
1-NBD-decanoyl-2-decanoyl-sn-Glycerol
Synonyms
1-NBD-1,2-bis(O-decanoyl-sn-glycerol);1-NBD-decanoyl-2-decanoyl-sn-Glycerol
CBNumber
CB92589964
Molecular Formula
C29H46N4O8
Formula Weight
578.69754
MOL File
2309189-98-6.mol
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1-NBD-decanoyl-2-decanoyl-sn-Glycerol Property

solubility 
DMF: 10 mg/ml; DMSO: 3 mg/ml; Ethanol: 10 mg/ml
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
9000341
Product name
1-NBD-decanoyl-2-decanoyl-sn-Glycerol
Purity
≥98%
Packaging
500μg
Price
$120
Updated
2024/03/01
Cayman Chemical
Product number
9000341
Product name
1-NBD-decanoyl-2-decanoyl-sn-Glycerol
Purity
≥98%
Packaging
1mg
Price
$228
Updated
2024/03/01
Cayman Chemical
Product number
9000341
Product name
1-NBD-decanoyl-2-decanoyl-sn-Glycerol
Purity
≥98%
Packaging
5mg
Price
$952
Updated
2024/03/01
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1-NBD-decanoyl-2-decanoyl-sn-Glycerol Chemical Properties,Usage,Production

Description

Diacylglycerols (DAG) are produced by the hydrolysis of membrane phospholipids. They act as lipid second messengers, activating PKC and regulating cell growth and apoptosis. They also serve as substrates for DAG kinases for the production of phosphatidic acid, another important lipid messenger. 1-NBD-decanoyl-2-decanoyl-sn-glycerol has the fluorophore nitrobenzoxadiazole (NBD) attached to the ω-end of the terminal decanoyl chain of the model diacylglycerol (DAG), 1,2-didecanoyl-sn-glycerol. 1-NBD-decanoyl-2-decanoyl-sn-glycerol is likely to have excitation/emission maxima of approximately 470/541 nm, respectively, based on the maxima of various NBD-labeled phospholipids.1 Fluorescently tagged lipids have been used to study their interactions with proteins, their utilization by cells and liposomes, and for the development of assays for lipid metabolism.2,3,4,5,6

Uses

1-NBD-decanoyl-2-decanoyl-sn-glycerol is a diacylglycerol (DAG) derivative, which is labeled with a fluorescent group NBD. 1-NBD-decanoyl-2-decanoyl-sn-glycerol is the substrate for diacylglycerol kinase (DGK), and can be used for quantitative detection of the DGF enzyme kinetics in vitro, and the changes in DAG and PA during cell signaling[1].

References

1. Mazères, S., Schram, V., Tocanne, J.F., et al. 7-nitrobenz-2-oxa-1,3-diazole-4-yl-labeled phospholipids in lipid membranes: Differences in fluorescence behavior Biophys J. 71(1),327-335(1996).
2. Kumagai, K., Yasuda, S., Okemoto, K., et al. CERT mediates intermembrane transfer of various molecular species of ceramides J. Biol. Chem. 280(8),6488-6495(2005).
3. Luo, M., Jones, S.M., Peters-Golden, M., et al. Nuclear localization of 5-lipoxygenase as a determinant of leukotriene B4 synthetic capacity Proc. Natl. Acad. Sci. USA 100(21),12165-12170(2003).
4. Moreno, M.J., Estronca, L.M.B.B., and Vaz, W.L.C. Translocation of phospholipids and dithionite permeability in liquid-ordered and liquid-disordered membranes Biophys. J. 91(3),873-881(2006).
5. Loidl, A., Claus, R., Deigner, H.P., et al. High-precision fluorescence assay for sphingomyelinase activity of isolated enzymes and cell lysates J. Lipid Res. 43(5),815-823(2002).
6. Tani, M., Okino, N., Mitsutake, S., et al. Specific and sensitive assay for alkaline and neutral ceramidases involving C12-NBD-ceramide J. Biochem. 125(4),746-749(1999).

1-NBD-decanoyl-2-decanoyl-sn-Glycerol Preparation Products And Raw materials

Raw materials

Preparation Products

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1-NBD-decanoyl-2-decanoyl-sn-Glycerol Suppliers

China 27 United States 1 Global 28
Shanghai Hongye Biotechnology Co. Ltd
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Cayman Chemical Company
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Guangzhou Squirrel Biotechnology Co., Ltd.
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2309189-98-6, 1-NBD-decanoyl-2-decanoyl-sn-GlycerolRelated Search:


  • 1-NBD-decanoyl-2-decanoyl-sn-Glycerol
  • 1-NBD-1,2-bis(O-decanoyl-sn-glycerol)
  • 2309189-98-6