2,2-DiMethyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester
- Product Name
- 2,2-DiMethyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester
- CAS No.
- 346593-03-1
- Chemical Name
- 2,2-DiMethyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester
- Synonyms
- tert-butyl 2,2-diMethyl-4-oxopiperidine-1-carboxylate;1-Boc-2,2-dimethyl-4-piperidone;1-Boc-2,2-diMethylpiperidin-4-one;1-tert-Butoxycarbonyl-2,2-dimethyl-4-piperidone;tert-butyl 2,2-dimethyl-4-oxo-1-piperidinecarboxylate;2,2-DiMethyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 2,2-dimethyl-4-oxo-, 1,1-dimethylethyl ester
- CBNumber
- CB92594199
- Molecular Formula
- C12H21NO3
- Formula Weight
- 227.3
- MOL File
- 346593-03-1.mol
2,2-DiMethyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester Property
- Boiling point:
- 303.4±35.0 °C(Predicted)
- Density
- 1.035±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -1.46±0.40(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C12H21NO3/c1-11(2,3)16-10(15)13-7-6-9(14)8-12(13,4)5/h6-8H2,1-5H3
- InChIKey
- DFWLCLMWDGTEHR-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC(=O)CC1(C)C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 4542AJ
- Product name
- tert-Butyl2,2-dimethyl-4-oxopiperidine-1-carboxylate
- Packaging
- 1g
- Price
- $495
- Updated
- 2021/12/16
- Product number
- 132440
- Product name
- tert-Butyl2,2-dimethyl-4-oxopiperidine-1-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $684
- Updated
- 2021/12/16
- Product number
- 4542AJ
- Product name
- tert-Butyl2,2-dimethyl-4-oxopiperidine-1-carboxylate
- Packaging
- 5g
- Price
- $1395
- Updated
- 2021/12/16
- Product number
- 132440
- Product name
- tert-Butyl2,2-dimethyl-4-oxopiperidine-1-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $2070
- Updated
- 2021/12/16
- Product number
- CM120325
- Product name
- 1-Boc-2,2-dimethylpiperidin-4-one
- Purity
- 98%
- Packaging
- 50g
- Price
- $2980
- Updated
- 2021/12/16
2,2-DiMethyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production
Synthesis
79099-07-3
74-88-4
346593-03-1
GENERAL STEPS: N-tert-butoxycarbonyl-4-piperidone (5 g, 25 mmol) was dissolved in tetrahydrofuran (100 mL) and the resulting solution was cooled to 0 °C. Under cooling conditions, sodium hydride (60% dispersed in mineral oil, 2.10 g, 53 mmol) was added all at once and the resulting turbid mixture was stirred for 10 minutes. Subsequently, iodomethane was added slowly and the reaction mixture was gradually warmed up to room temperature with continuous stirring overnight (12 hours). Upon completion of the reaction, the light orange colored mixture was concentrated under reduced pressure. The concentrated residue was extracted by partitioning with ether and water. The aqueous phase was back-extracted with ether and all organic phases were combined, washed sequentially with water and saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated to give a light yellow solid. The solid was ground with a hexane solution of 4% ethyl acetate (50 mL) to afford 1-Boc-2,2-dimethylpiperidin-4-one as a cream-colored solid (1.8 g, 32% yield). The product was characterized by 1H-NMR (CDCl3, 300 MHz): δ 3.73 (t, 2H), 3.43 (br s, 2H), 2.49 (t, 2H), 1.49 (s, 9H), 1.13 (s, 6H).
References
[1] Patent: US2005/239781, 2005, A1. Location in patent: Page/Page column 110
2,2-DiMethyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,2-DiMethyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester manufacturers
- Product
- 2,2-DiMethyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester 346593-03-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-24