5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester

Product Name: 5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester
CAS No.: 172678-67-0
Chemical Name: 5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester
Synonyms: ethyl 2-phenylthiazole-5-carboxylate;5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester
CBNumber: CB92594492
Molecular Formula: C12H11NO2S
Formula Weight: 233.29
MOL File: 172678-67-0.mol

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5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester Property

Melting point:: 64.8-65.8 °C
Boiling point:: 365.2±34.0 °C(Predicted)
Density: 1.216±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 0.61±0.10(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: Y5301
Product name: Ethyl2-phenylthiazole-5-carboxylate
Packaging: 100mg
Price: $212
Updated: 2021/12/16

AK Scientific

Product number: Y5301
Product name: Ethyl2-phenylthiazole-5-carboxylate
Packaging: 250mg
Price: $309
Updated: 2021/12/16

AK Scientific

Product number: Y5301
Product name: Ethyl2-phenylthiazole-5-carboxylate
Packaging: 1g
Price: $698
Updated: 2021/12/16

Matrix Scientific

Product number: 180907
Product name: 2-Phenylthiazole-5-carboxylic acid ethyl ester
Purity: 95%+
Packaging: 1g
Price: $728
Updated: 2021/12/16

AK Scientific

Product number: Y5301
Product name: Ethyl2-phenylthiazole-5-carboxylate
Packaging: 5g
Price: $1994
Updated: 2021/12/16

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5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester Chemical Properties,Usage,Production

Synthesis

33142-21-1

2227-79-4

172678-67-0

To a solution of ethyl 2-chloro-3-oxopropionate (4.5 g, 30.0 mmol) and thiobenzamide (4.1 g, 30.0 mmol) in toluene (50 mL) was added magnesium sulfate heptahydrate (7.2 g, 59.8 mmol). The reaction mixture was stirred at 100 °C for 4 h. Upon completion of the reaction, the reaction was quenched with ice water (100 mL). Subsequently, the reaction mixture was extracted with ether (3 x 50 mL), the organic phases were combined, washed with saturated brine (50 mL) and dried over anhydrous sodium sulfate. The drier was removed by filtration and the filtrate was concentrated under reduced pressure to give the crude product ethyl 2-phenylthiazole-5-carboxylate. The crude product was purified by silica gel column chromatography, using petroleum ether/ethyl acetate (10:1) as eluent, the target fraction was collected, and the pure ethyl 2-phenylthiazole-5-carboxylate was obtained after concentration under reduced pressure (3.2 g, 45.9% yield). Mass spectrum (ESI) m/z: 234.1 [M+H]+.

References

[1] Patent: US2018/271846, 2018, A1. Location in patent: Paragraph 0121; 0124; 0125
[2] Patent: WO2018/160878, 2018, A1. Location in patent: Page/Page column 287-288
[3] Journal of Chemical Research, 2011, vol. 35, # 5, p. 313 - 316

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View Lastest Price from 5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester manufacturers

Career Henan Chemica Co

Product: 5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester 172678-67-0
Price: US $0.01/KG
Min. Order: 1KG
Purity: 95%-99%
Supply Ability: 1kg; 5kg; 10kg
Release date: 2020-10-27

172678-67-0, 5-Thiazolecarboxylic acid, 2-phenyl-, ethyl esterRelated Search:

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5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester

ethyl 2-phenylthiazole-5-carboxylate

172678-67-0