ChemicalBook > CAS DataBase List > 4-(1,2,4-TRIAZOL-1-YL)ANILINE

4-(1,2,4-TRIAZOL-1-YL)ANILINE

Product Name
4-(1,2,4-TRIAZOL-1-YL)ANILINE
CAS No.
6523-49-5
Chemical Name
4-(1,2,4-TRIAZOL-1-YL)ANILINE
Synonyms
AKOS B021934;triazolylaniline;BUTTPARK 95\50-84;ART-CHEM-BB B021934;4-[1,2,4]TRIAZOL-1-YLANILINE;1-p-AMinophenyl-1,2,4-triazole;4-(1,3,4-triazolyl)phenylamine;1-(4-AMINOPHENYL)-1,2,4-TRIAZOLE;4-(1H-1,2,4-TRIAZOL-1-YL)ANILINE;4-[1,2,4]TRIAZOL-1-YL-PHENYLAMINE
CBNumber
CB9259559
Molecular Formula
C8H8N4
Formula Weight
160.18
MOL File
6523-49-5.mol
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4-(1,2,4-TRIAZOL-1-YL)ANILINE Property

Melting point:
142 °C
Boiling point:
375.3±44.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
powder to crystal
pka
3.52±0.10(Predicted)
color 
White to Gray to Red
CAS DataBase Reference
6523-49-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39-24/25
Hazard Note 
Irritant
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical
Product number
T3013
Product name
4-(1,2,4-Triazol-1-yl)aniline
Purity
>98.0%(GC)(T)
Packaging
200mg
Price
$77
Updated
2025/07/31
TCI Chemical
Product number
T3013
Product name
4-(1,2,4-Triazol-1-yl)aniline
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$268
Updated
2024/03/01
TRC
Product number
T767455
Product name
4-(1,2,4-Triazol-1-yl)aniline
Packaging
5g
Price
$1260
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-1-4D
Product name
1-(4-Aminophenyl)-1,2,4-triazole
Purity
95%
Packaging
100g
Price
$760
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
COR0002812
Product name
4-(1H-1,2,4-TRIAZOL-1-YL)ANILINE
Purity
95.00%
Packaging
500MG
Price
$424.8
Updated
2021/12/16
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4-(1,2,4-TRIAZOL-1-YL)ANILINE Chemical Properties,Usage,Production

Uses

4-(1,2,4-Triazol-1-yl)aniline is used in the preparation of pyrimidine compounds that inhibit anaplastic lymphoma kinase and are useful in the treatment of cancers.

Synthesis

6219-55-2

6523-49-5

1-(4-Nitrophenyl)-1H-1,2,4-triazole (3.0 g, 15.78 mmol) was used as a raw material and co-dissolved with ammonium chloride (2.1 g, 39.62 mmol) in 50% ethanol-water mixed solvent (60 mL). Zinc powder (2.6 g, 40 mmol) was then added and the reaction mixture was heated to reflux for 30 min. After completion of the reaction, it was cooled to room temperature, filtered to remove insoluble material and the filter cake was washed with ethanol (10 mL). The filtrates were combined and concentrated under reduced pressure to remove the solvent, the residue was diluted with water (100 mL) and extracted with ethyl acetate (100 mL x 3). The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford 4-(1H-1,2,4-triazol-1-yl)aniline (1.1 g, yield: 81%) as a yellow solid, and the product could be used in the subsequent reaction without further purification. m/z = 161 [M + H]+ by LC-MS (ESI) analysis.

References

[1] Chemical and Pharmaceutical Bulletin, 2000, vol. 48, # 12, p. 1935 - 1946
[2] Patent: US2015/336982, 2015, A1. Location in patent: Paragraph 0160; 0162
[3] Applied Spectroscopy, 1995, vol. 49, # 8, p. 1111 - 1119
[4] Patent: US2005/143384, 2005, A1. Location in patent: Page/Page column 23-24
[5] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2012, vol. 51, # 5, p. 731 - 738

4-(1,2,4-TRIAZOL-1-YL)ANILINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(1,2,4-TRIAZOL-1-YL)ANILINE Suppliers

Belgium 1 Canada 1 China 83 France 1 Germany 3 India 6 Japan 1 Russia 2 Ukraine 1 United Kingdom 11 United States 19 Global 129
J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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4006356688 18621169109
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86-21-61259102
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market03@meryer.com
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China
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Energy Chemical
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021-021-58432009 400-005-6266
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sales8178@energy-chemical.com
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China
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Wuhan Chemwish Technology Co., Ltd
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86-027-67849912
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86-027-87531808
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+86 (0) 571 85 58 67 18
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Beijing Ouhe Technology Co., Ltd
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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
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Accela ChemBio Co.,Ltd.
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021-50795055
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Nanjing Chemlin Chemical Co., Ltd
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025-83697070
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+86-25-83453306
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Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
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China
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View Lastest Price from 4-(1,2,4-TRIAZOL-1-YL)ANILINE manufacturers

Shanghai UCHEM Inc.
Product
1-(4'-aminophenyl)-1,2,4-triazole 6523-49-5
Price
US $14.00-237.00/g
Min. Order
5g
Purity
0.97
Supply Ability
25kg
Release date
2024-10-25
Career Henan Chemical Co
Product
1-(4'-AMINOPHENYL)-1,2,4-TRIAZOLE 6523-49-5
Price
US $8.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10tons
Release date
2018-12-24

6523-49-5, 4-(1,2,4-TRIAZOL-1-YL)ANILINERelated Search:

4-(1,2,4-TRIAZOL-1-YL)ANILINE 4-(2-METHYL-1,3-THIAZOL-4-YL)ANILINE 3-(2-METHYL-1,3-THIAZOL-4-YL)ANILINE 4-(4-AMINOPHENYL)-1,2,4-TRIAZOLE 1,2,4-Triazole 5-METHYL-1-(4-NITROPHENYL)-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID 4-(1H-TETRAZOL-1-YL)ANILINE N-(2,4-DIFLUOROPHENYL)-5-METHYL-1-(4-NITROPHENYL)-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE 5-METHYL-1-(4-NITROPHENYL)-N-PHENYL-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE 2-(2,2-DIMETHYLPROPANOYL)-3-((4-(1,2,4-TRIAZOLYL)PHENYL)AMINO)PROP-2-ENENITRILE N-(2,4-DICHLOROPHENYL)-5-METHYL-1-(4-NITROPHENYL)-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE N-(4-FLUOROPHENYL)-5-METHYL-1-(4-NITROPHENYL)-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE N-(4-METHOXYPHENYL)-5-METHYL-1-(4-NITROPHENYL)-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE (3-(2-CHLOROPHENYL)-5-METHYLISOXAZOL-4-YL)-N-(4-(1,2,4-TRIAZOLYL)PHENYL)FORMAMIDE N-(4-CHLOROPHENYL)-5-METHYL-1-(4-NITROPHENYL)-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE (2-CHLORO(3-PYRIDYL))-N-(4-(1,2,4-TRIAZOLYL)PHENYL)FORMAMIDE ETHYL 5-METHYL-1-(4-NITROPHENYL)-1H-1,2,4-TRIAZOLE-3-CARBOXYLATE (((4-(1,2,4-TRIAZOLYL)PHENYL)AMINO)METHYLENE)METHANE-1,1-DICARBONITRILE

  • BUTTPARK 95\50-84
  • BENZENAMINE, 4-(1H-1,2,4-TRIAZOL-1-YL)-
  • ART-CHEM-BB B021934
  • 1-(4-AMINOPHENYL)-1,2,4-TRIAZOLE
  • 4-[1,2,4]TRIAZOL-1-YLANILINE
  • 4-[1,2,4]TRIAZOL-1-YL-PHENYLAMINE
  • 4-(1H-1,2,4-TRIAZOL-1-YL)ANILINE
  • AKOS B021934
  • 1-(4-Aminophenyl)-1,2,4-triazole 95%
  • triazolylaniline
  • [4-(1H-[1,2,4]Triazol-1-yl)phenyl]aMine
  • 1-(p-AMinophenyl)-1H-1,2,4-triazole
  • 1-p-AMinophenyl-1,2,4-triazole
  • 4-(1H-1,2,4-Triazol-1-yl)benzenaMine
  • 1-(4-Aminophenyl)-1,2,4-triazole95%
  • JR-13923, 4-(1H-1,2,4-Triazol-1-yl)benzenamine
  • 4-(1,3,4-triazolyl)phenylamine
  • 1-(4'-aminophenyl)-1,2,4-triazole
  • 4-(1<i>H</i>-1,2,4-Triazol-1-yl)aniline
  • 6523-49-5
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Phenyls & Phenyl-Het
  • Amines
  • Phenyls & Phenyl-Het