Methyl 1-Methyl-4-nitro-1H-pyrazole-5-carboxylate
- Product Name
- Methyl 1-Methyl-4-nitro-1H-pyrazole-5-carboxylate
- CAS No.
- 309740-49-6
- Chemical Name
- Methyl 1-Methyl-4-nitro-1H-pyrazole-5-carboxylate
- Synonyms
- Methyl 1-Methyl-4-nitro-1...;methyl2-methyl-4-nitropyrazole-3-carboxylate;Methyl 1-Methyl-4-nitropyrazole-5-carboxylate;Methyl 1-methyl-4-nitro-1H-pyrazol-5-carboxylate;1-methyl-4-nitro-1H-pyrazole-5-methyl carboxylate;Methyl 1-Methyl-4-nitro-1H-pyrazole-5-carboxylate;1H-Pyrazole-5-carboxylic acid, 1-methyl-4-nitro-, methyl ester
- CBNumber
- CB92597387
- Molecular Formula
- C6H7N3O4
- Formula Weight
- 185.14
- MOL File
- 309740-49-6.mol
Methyl 1-Methyl-4-nitro-1H-pyrazole-5-carboxylate Property
- Melting point:
- 38-41 °C(Solv: heptane (142-82-5))
- Boiling point:
- 306.6±22.0 °C(Predicted)
- Density
- 1.49±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -3.85±0.10(Predicted)
- Appearance
- Light brown to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M338568
- Product name
- Methyl1-Methyl-4-nitro-1H-pyrazole-5-carboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 6413CE
- Product name
- Methyl1-methyl-4-nitro-1H-pyrazole-5-carboxylate
- Packaging
- 1g
- Price
- $93
- Updated
- 2021/12/16
- Product number
- CHM1019449
- Product name
- METHYL-1-METHYL-4-NITRO-1H-PYRAZOLE-5-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.64
- Updated
- 2021/12/16
- Product number
- 115725
- Product name
- Methyl 1-methyl-4-nitro-1H-pyrazole-5-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $519
- Updated
- 2021/12/16
- Product number
- 6413CE
- Product name
- Methyl1-methyl-4-nitro-1H-pyrazole-5-carboxylate
- Packaging
- 5g
- Price
- $201
- Updated
- 2021/12/16
Methyl 1-Methyl-4-nitro-1H-pyrazole-5-carboxylate Chemical Properties,Usage,Production
Synthesis
138786-86-4
74-88-4
400877-57-8
309740-49-6
The reaction was carried out with 4-nitro-1H-pyrazole-3-carboxylic acid methyl ester (2.0 g, 11.7 mmol) and iodomethane (2.0 g, 14.0 mmol) in the presence of potassium carbonate (1.62 g, 11.7 mmol) in acetone (60 mL) and stirred for 5 hours at 30°C. After completion of the reaction, the mixture was diluted with water and extracted with chloroform. The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The resulting crude product was purified by silica gel column chromatography (eluent: hexane-ethyl acetate from 4:1 to 1:1) to isolate two major products: methyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate (Rf values 0.43, 0.95 g, 44% yield) and methyl 1-methyl-4-nitro-1H-pyrazole-5-carboxylate (Rf values 0.71, 0.61 g, 28% yield).
References
[1] Patent: WO2011/154327, 2011, A1. Location in patent: Page/Page column 136; 137
[2] Patent: US2010/63106, 2010, A1. Location in patent: Page/Page column 11;13
[3] Patent: WO2008/51047, 2008, A1. Location in patent: Page/Page column 25; 28-29
[4] Patent: US2009/156582, 2009, A1. Location in patent: Page/Page column 30
[5] Patent: EP1847531, 2007, A1. Location in patent: Page/Page column 43
Methyl 1-Methyl-4-nitro-1H-pyrazole-5-carboxylate Preparation Products And Raw materials
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