3-Quinolinecarboxylic acid, 8-chloro-6,7-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-

Product Name: 3-Quinolinecarboxylic acid, 8-chloro-6,7-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-
CAS No.: 127199-27-3
Chemical Name: 3-Quinolinecarboxylic acid, 8-chloro-6,7-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-
Synonyms: Sitafloxacin Impurity 63;8-Chloro-6,7-difluoro-1-((1R,2S)-2-fluorocyclopropyl)--4-oxo-1,4-dihydroquinoline-3-carboxylic;8-chloro-6,7-difluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;8-Chloro-6,7-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid;8-Chloro-6,7-difluoro-1-[(1R,2S)-2-fluoro-cyclopropyl]-1,4-dihydro-4-oxo-quinolin-3-carboxylic acid;(1R-cis)-8-Chloro-6,7-difluoro-1-(2-fluorocyclopropyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid;3-Quinolinecarboxylic acid, 8-chloro-6,7-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-
CBNumber: CB92597721
Molecular Formula: C13H7ClF3NO3
Formula Weight: 317.65
MOL File: 127199-27-3.mol

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3-Quinolinecarboxylic acid, 8-chloro-6,7-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo- Property

Boiling point:: 475.6±45.0 °C(Predicted)
Density: 1.71
storage temp.: 2-8°C
pka: 6.33±0.50(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C377703
Product name: 8-Chloro-6,7-difluoro-1-((1r,2s)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylicacid
Packaging: 50mg
Price: $50
Updated: 2021/12/16

Activate Scientific

Product number: AS40864-1R2S
Product name: 8-Chloro-6,7-difluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 9
Packaging: 250mg
Price: $258
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0032674
Product name: 8-CHLORO-6,7-DIFLUORO-1-((1R,2S)-2-FLUOROCYCLOPROPYL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $500.58
Updated: 2021/12/16

Activate Scientific

Product number: AS40864-1R2S
Product name: 8-Chloro-6,7-difluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 9
Packaging: 1g
Price: $504
Updated: 2021/12/16

AK Scientific

Product number: 5320AA
Product name: 8-Chloro-6,7-difluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylicacid
Packaging: 5g
Price: $1241
Updated: 2021/12/16

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3-Quinolinecarboxylic acid, 8-chloro-6,7-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo- Chemical Properties,Usage,Production

Synthesis

127199-25-1

127199-27-3

Ethyl 8-chloro-6,7-difluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-ethyl-1,4-dihydroquinoline-3-carboxylate (Compound 3, 12.4 g, 34.3 mmol) was used as raw material. Compound 3 was dissolved in a mixture of hydrochloric acid (125 mL) and acetic acid (125 mL). The reaction mixture was stirred at 120-130°C for 2 hours. After completion of the reaction, the reaction solution was diluted with deionized water (500 mL) and the precipitate was collected by filtration. The precipitate was washed sequentially with deionized water and ether and then dried under reduced pressure to afford the target product 8-chloro-6,7-difluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (Compound 4, 8.72 g, 76.2% yield) as a colorless solid.

References

[1] Journal of Medicinal Chemistry, 1994, vol. 37, # 20, p. 3344 - 3352
[2] Asian Journal of Chemistry, 2014, vol. 26, # 20, p. 7049 - 7051

3-Quinolinecarboxylic acid, 8-chloro-6,7-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo- Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Quinolinecarboxylic acid, 8-chloro-6,7-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo- Suppliers

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View Lastest Price from 3-Quinolinecarboxylic acid, 8-chloro-6,7-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo- manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 8-Chloro-6,7-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 127199-27-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

Career Henan Chemical Co

Product: 3-Quinolinecarboxylic acid, 8-chloro-6,7-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo- 127199-27-3
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2018-07-26

127199-27-3, 3-Quinolinecarboxylic acid, 8-chloro-6,7-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-Related Search:

Sitafloxacin Impurity 12 Sitafloxacin Sesquihydrate Carbamic acid, (7S)-5-azaspiro[2.4]hept-7-yl-, 1,1-dimethylethyl ester (9CI) ETHYL 3-(3-CHLORO-2,4,5-TRIFLUOROPHENYL)-3-OXOPROPANOATE (1R,2S)-FLUOROCYCLOPROPYLAMINE TOSYLATE tert-Butyl (S)-(5-benzyl-5-azaspiro[2.4]heptan-7-yl)carbamate Sitafloxacin RRS isomer DU 6856 Sitafloxacin Impurity 14 7-((R)-7amino-5-azaspiro[2.4]heptan-5-yl)-8-chloro-6-fluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid Sitafloxacin RSS isomer Sitagliptin Impurity C Sitafloxacin RSR isomer Sitafloxacin Isomer Impurity 6 Sitafloxacin Isomer Impurity 4 Citarfloxacin impurity D Citarfloxacin impurity B Sitafloxacin Isomer Impurity 5

3-Quinolinecarboxylic acid, 8-chloro-6,7-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-

(1R-cis)-8-Chloro-6,7-difluoro-1-(2-fluorocyclopropyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

8-Chloro-6,7-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

8-chloro-6,7-difluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

8-Chloro-6,7-difluoro-1-((1R,2S)-2-fluorocyclopropyl)--4-oxo-1,4-dihydroquinoline-3-carboxylic

Sitafloxacin Impurity 63

8-Chloro-6,7-difluoro-1-[(1R,2S)-2-fluoro-cyclopropyl]-1,4-dihydro-4-oxo-quinolin-3-carboxylic acid

127199-27-3