2-chloro-3-fluoropyridin-4-aMine

Uses

Product Name: 2-chloro-3-fluoropyridin-4-aMine
CAS No.: 1227577-03-8
Chemical Name: 2-chloro-3-fluoropyridin-4-aMine
Synonyms: 2-chloro-3-fluoropyridin-4-aMine;2-Chloro-3-fluoro-4-pyridinamine;4-Amino-2-chloro-3-fluoropyridine;4-Pyridinamine, 2-chloro-3-fluoro-;2-Chloro-3-fluoro-pyridin-4-ylamine
CBNumber: CB92598773
Molecular Formula: C5H4ClFN2
Formula Weight: 146.55
MOL File: 1227577-03-8.mol

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2-chloro-3-fluoropyridin-4-aMine Property

Boiling point:: 271.9±35.0 °C(Predicted)
Density: 1.449±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 2.81±0.42(Predicted)
form: powder
color: Brown
InChI: InChI=1S/C5H4ClFN2/c6-5-4(7)3(8)1-2-9-5/h1-2H,(H2,8,9)
InChIKey: VUGYOFOYGPXOFL-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=CC(N)=C1F

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: C369798
Product name: 2-Chloro-3-fluoropyridin-4-amine
Packaging: 50mg
Price: $65
Updated: 2021/12/16

TRC

Product number: C369798
Product name: 2-Chloro-3-fluoropyridin-4-amine
Packaging: 100mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-W021639
Product name: 2-Chloro-3-fluoropyridin-4-amine
Purity: 99.90%
Packaging: 1g
Price: $93
Updated: 2021/12/16

Apolloscientific

Product number: PC400526
Product name: 4-Amino-2-chloro-3-fluoropyridine
Packaging: 1g
Price: $93
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-7-0A
Product name: 4-Amino-2-chloro-3-fluoropyridine
Packaging: 1g
Price: $103
Updated: 2021/12/16

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2-chloro-3-fluoropyridin-4-aMine Chemical Properties,Usage,Production

Uses

2-Chloro-3-fluoro-4-aminopyridine is a highly useful class of pyridine derivatives, serving as an important pharmaceutical and pesticide intermediate. It can be used as a viscosity modifier, in the synthesis of anti-peptic ulcer drug pelenzapine, diazepine anti-HIV drugs, leukotriene biosynthesis inhibitors, and as a pharmaceutical intermediate for insecticides. Furthermore, 2-chloro-3-fluoro-4-aminopyridine and its derivatives can also be used as raw materials for food additives, ultra-efficient quenching catalysts, and directly as pharmaceutical and analytical reagents.

Synthesis

TFA (5 mL) was added to a solution of (2- chloro-3-fluoropyridin-4-yl)carbamic acid fert-butyl ester (1.9 g, 7.7 mmol) in DCM (10 mL). The solution was stirred at ambient temperature for 5 hours and concentrated under reduced pressure. The resultant residue was dissolved in DCM and purified by column chromatography on an NH2 cartridge (0-10 per cent MeOH in DCM) to afford 2-chloro-3-fluoropyridin-4-aMine as a beige solid (0.96 g, 94 per cent yield). NMR (400 MHz, CDC13): δ 7.82 (d, J = 5.4 Hz, 1H), 6.60 (t, J= 5.8 Hz, 1H), 4.38 (br s, 2H).

References

[1] Patent: WO2012/35039, 2012, A1. Location in patent: Page/Page column 97
[2] Patent: US2015/203455, 2015, A1. Location in patent: Paragraph 0461; 0463
[3] Patent: WO2015/110378, 2015, A1. Location in patent: Paragraph 00263; 00312
[4] Patent: US9440929, 2016, B2. Location in patent: Page/Page column 59; 60
[5] Patent: WO2017/12647, 2017, A1. Location in patent: Paragraph 0502

2-chloro-3-fluoropyridin-4-aMine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-chloro-3-fluoropyridin-4-aMine Suppliers

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View Lastest Price from 2-chloro-3-fluoropyridin-4-aMine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-chloro-3-fluoropyridin-4-aMine 1227577-03-8
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-15

1227577-03-8, 2-chloro-3-fluoropyridin-4-aMineRelated Search:

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2-chloro-3-fluoropyridin-4-aMine

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2-Chloro-3-fluoro-4-pyridinamine

1227577-03-8