Uses
ChemicalBook > CAS DataBase List > 2-chloro-3-fluoropyridin-4-aMine

2-chloro-3-fluoropyridin-4-aMine

Uses
Product Name
2-chloro-3-fluoropyridin-4-aMine
CAS No.
1227577-03-8
Chemical Name
2-chloro-3-fluoropyridin-4-aMine
Synonyms
2-chloro-3-fluoropyridin-4-aMine;2-Chloro-3-fluoro-4-pyridinamine;4-Amino-2-chloro-3-fluoropyridine;4-Pyridinamine, 2-chloro-3-fluoro-;2-Chloro-3-fluoro-pyridin-4-ylamine
CBNumber
CB92598773
Molecular Formula
C5H4ClFN2
Formula Weight
146.55
MOL File
1227577-03-8.mol
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2-chloro-3-fluoropyridin-4-aMine Property

Boiling point:
271.9±35.0 °C(Predicted)
Density 
1.449±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
2.81±0.42(Predicted)
form 
powder
color 
Brown
InChI
InChI=1S/C5H4ClFN2/c6-5-4(7)3(8)1-2-9-5/h1-2H,(H2,8,9)
InChIKey
VUGYOFOYGPXOFL-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=CC(N)=C1F
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
C369798
Product name
2-Chloro-3-fluoropyridin-4-amine
Packaging
50mg
Price
$65
Updated
2021/12/16
TRC
Product number
C369798
Product name
2-Chloro-3-fluoropyridin-4-amine
Packaging
100mg
Price
$90
Updated
2021/12/16
ChemScene
Product number
CS-W021639
Product name
2-Chloro-3-fluoropyridin-4-amine
Purity
99.90%
Packaging
1g
Price
$93
Updated
2021/12/16
Apolloscientific
Product number
PC400526
Product name
4-Amino-2-chloro-3-fluoropyridine
Packaging
1g
Price
$93
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-7-0A
Product name
4-Amino-2-chloro-3-fluoropyridine
Packaging
1g
Price
$103
Updated
2021/12/16
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2-chloro-3-fluoropyridin-4-aMine Chemical Properties,Usage,Production

Uses

2-Chloro-3-fluoro-4-aminopyridine is a highly useful class of pyridine derivatives, serving as an important pharmaceutical and pesticide intermediate. It can be used as a viscosity modifier, in the synthesis of anti-peptic ulcer drug pelenzapine, diazepine anti-HIV drugs, leukotriene biosynthesis inhibitors, and as a pharmaceutical intermediate for insecticides. Furthermore, 2-chloro-3-fluoro-4-aminopyridine and its derivatives can also be used as raw materials for food additives, ultra-efficient quenching catalysts, and directly as pharmaceutical and analytical reagents.

Synthesis

TFA (5 mL) was added to a solution of (2- chloro-3-fluoropyridin-4-yl)carbamic acid fert-butyl ester (1.9 g, 7.7 mmol) in DCM (10 mL). The solution was stirred at ambient temperature for 5 hours and concentrated under reduced pressure. The resultant residue was dissolved in DCM and purified by column chromatography on an NH2 cartridge (0-10 per cent MeOH in DCM) to afford 2-chloro-3-fluoropyridin-4-aMine as a beige solid (0.96 g, 94 per cent yield). NMR (400 MHz, CDC13): δ 7.82 (d, J = 5.4 Hz, 1H), 6.60 (t, J= 5.8 Hz, 1H), 4.38 (br s, 2H).

References

[1] Patent: WO2012/35039, 2012, A1. Location in patent: Page/Page column 97
[2] Patent: US2015/203455, 2015, A1. Location in patent: Paragraph 0461; 0463
[3] Patent: WO2015/110378, 2015, A1. Location in patent: Paragraph 00263; 00312
[4] Patent: US9440929, 2016, B2. Location in patent: Page/Page column 59; 60
[5] Patent: WO2017/12647, 2017, A1. Location in patent: Paragraph 0502

2-chloro-3-fluoropyridin-4-aMine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-chloro-3-fluoropyridin-4-aMine Suppliers

Canada 1 China 125 India 4 United Kingdom 1 United States 7 Global 138
Accela ChemBio Inc.
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+1-858-6993322
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SynQuest Laboratories, Inc.
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Matrix Scientific
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View Lastest Price from 2-chloro-3-fluoropyridin-4-aMine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-chloro-3-fluoropyridin-4-aMine 1227577-03-8
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-15

1227577-03-8, 2-chloro-3-fluoropyridin-4-aMineRelated Search:

4-broMo-2-chloro-3-fluoropyridine 2-CHLORO-3-FLUOROPYRIDINE-4-BORONIC ACID

  • 4-Amino-2-chloro-3-fluoropyridine
  • 2-Chloro-3-fluoro-pyridin-4-ylamine
  • 2-chloro-3-fluoropyridin-4-aMine
  • 4-Pyridinamine, 2-chloro-3-fluoro-
  • 2-Chloro-3-fluoro-4-pyridinamine
  • 1227577-03-8