2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine

Product Name: 2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine
CAS No.: 90213-67-5
Chemical Name: 2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine
Synonyms: 2,4-dichloro-7-methylpyrrolo[2,3-d]pyrimidine;2,4-Dichlor-7-methyl-7H-pyrrolo[2,3-d]pyrimidin;2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine;7H-Pyrrolo[2,3-d]pyrimidine, 2,4-dichloro-7-methyl-
CBNumber: CB92599442
Molecular Formula: C7H5Cl2N3
Formula Weight: 202.04
MOL File: 90213-67-5.mol

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2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: Off-white to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H303May be harmfulif swallowed

H320Causes eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-W006113
Product name: 2,4-Dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
Purity: 98.69%
Packaging: 1g
Price: $40
Updated: 2021/12/16

ChemScene

Product number: CS-W006113
Product name: 2,4-Dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
Purity: 98.69%
Packaging: 5g
Price: $112
Updated: 2021/12/16

ChemScene

Product number: CS-W006113
Product name: 2,4-Dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
Purity: 98.69%
Packaging: 10g
Price: $205
Updated: 2021/12/16

Matrix Scientific

Product number: 119557
Product name: 2,4-Dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
Purity: 95+%
Packaging: 1g
Price: $324
Updated: 2021/12/16

AK Scientific

Product number: W9290
Product name: 2,4-Dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
Packaging: 10g
Price: $334
Updated: 2021/12/16

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2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine Chemical Properties,Usage,Production

Synthesis

90213-66-4

74-88-4

90213-67-5

To a suspension of sodium hydride (480 mg, 12.00 mmol, 1.10 eq., 60% dispersed in mineral oil) in tetrahydrofuran (50 mL) was slowly added dropwise a solution of 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine (2 g, 10.64 mmol, 1.00 eq.) in tetrahydrofuran (50 mL). The reaction mixture was stirred at 0 °C for 30 min and then iodomethane (1.66 g, 11.70 mmol, 1.10 eq.) was added dropwise at the same temperature. After addition, the reaction system was brought to room temperature and stirred overnight. Upon completion of the reaction, the reaction was quenched by the addition of water (20 mL) to the mixture and subsequently extracted with ethyl acetate. The combined organic phases were washed with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with ethyl acetate/petroleum ether (1:5, v/v) as eluent to afford 2.1 g (98% yield) of the title compound, 2,4-dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine, as a white solid.LC-MS (ESI, m/z): 202 [M+H]+.

References

[1] Patent: US2015/57260, 2015, A1. Location in patent: Paragraph 0436; 0437; 0588; 0589
[2] Patent: WO2015/25026, 2015, A1. Location in patent: Page/Page column 118
[3] Patent: WO2017/59191, 2017, A1. Location in patent: Paragraph 00235-00239
[4] Patent: WO2017/46739, 2017, A1. Location in patent: Page/Page column 51
[5] Patent: CN107226808, 2017, A. Location in patent: Paragraph 0366-0369

2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine Suppliers

China 43 India 1 United States 7 Global 51

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90213-67-5, 2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidineRelated Search:

2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine

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90213-67-5

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