(AS)-ALPHA-AMINO-3-[(4-CARBOXYPHENYL)METHYL]-3,4-DIHYDRO-5-IODO-2,4-DIOXO-1(2H)-PYRIMIDINEPROPANOIC ACID
- Product Name
- (AS)-ALPHA-AMINO-3-[(4-CARBOXYPHENYL)METHYL]-3,4-DIHYDRO-5-IODO-2,4-DIOXO-1(2H)-PYRIMIDINEPROPANOIC ACID
- CAS No.
- 569371-10-4
- Chemical Name
- (AS)-ALPHA-AMINO-3-[(4-CARBOXYPHENYL)METHYL]-3,4-DIHYDRO-5-IODO-2,4-DIOXO-1(2H)-PYRIMIDINEPROPANOIC ACID
- Synonyms
- UBP 301;UBP-301,UBP301;(αS)-α-Amino-3-[(4-carboxyphenyl)methyl]-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoicacid;(aS)-a-Amino-3-((4-carboxyphenyl)methyl)-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoicacid;1(2H)-Pyrimidinepropanoic acid, α-amino-3-[(4-carboxyphenyl)methyl]-3,4-dihydro-5-iodo-2,4-dioxo-, (αS)-;(AS)-ALPHA-AMINO-3-[(4-CARBOXYPHENYL)METHYL]-3,4-DIHYDRO-5-IODO-2,4-DIOXO-1(2H)-PYRIMIDINEPROPANOIC ACID;(alphaS)-alpha-Amino-3-[(4-carboxyphenyl)methyl]-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoic acid
- CBNumber
- CB9260069
- Molecular Formula
- C15H14IN3O6
- Formula Weight
- 459.19
- MOL File
- 569371-10-4.mol
(AS)-ALPHA-AMINO-3-[(4-CARBOXYPHENYL)METHYL]-3,4-DIHYDRO-5-IODO-2,4-DIOXO-1(2H)-PYRIMIDINEPROPANOIC ACID Property
- Melting point:
- 214.1-214.4 °C(Solv: water (7732-18-5))
- Boiling point:
- 636.1±65.0 °C(Predicted)
- Density
- 1.98±0.1 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- DMSO: 0.5 mg/ml (w/ gentle warming)
- form
- A crystalline solid
- pka
- 2.12±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- 17597
- Product name
- UBP 301
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 17597
- Product name
- UBP 301
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 17597
- Product name
- UBP 301
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $214
- Updated
- 2024/03/01
- Product number
- 1766
- Product name
- UBP301
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $844
- Updated
- 2021/12/16
- Product number
- 1766
- Product name
- UBP301
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $205
- Updated
- 2021/12/16
(AS)-ALPHA-AMINO-3-[(4-CARBOXYPHENYL)METHYL]-3,4-DIHYDRO-5-IODO-2,4-DIOXO-1(2H)-PYRIMIDINEPROPANOIC ACID Chemical Properties,Usage,Production
Description
UBP 301 is an antagonist of the kainate receptor, an ionotropic glutamate receptor (apparent Kd = 5.94 μM). It displays ~30-fold selectivity over AMPA receptors. UBP 301 is used to assess the roles of kainate receptors in neuronal signaling, particularly in reference to neuropathic pain.
Uses
UBP 301 is an antagonist of kainate receptors. UBP 301 is the N3-4-carboxybenzyl substituted analog II of Willardiine, which was found to be equipotent at AMPA and GLUK5-containing kainate receptors in the neonatal rat spinal cord.
Biological Activity
Potent kainate receptor antagonist (apparent K d = 5.94 mM). Displays ~ 30-fold selectivity over AMPA receptors.
storage
Store at +4°C
References
[1] JULIA C A MORE. Structural requirements for novel willardiine derivatives acting as AMPA and kainate receptor antagonists[J]. British Journal of Pharmacology, 2009, 138 6: 1093-1100. DOI: 10.1038/sj.bjp.0705148
[2] SUZANNE DOOLEN. Peripheral nerve injury increases glutamate-evoked calcium mobilization in adult spinal cord neurons.[J]. Molecular Pain, 2012, 8: 56. DOI: 10.1186/1744-8069-8-56
[3] DOREEN B OSGOOD. The utility of ionotropic glutamate receptor antagonists in the treatment of nociception induced by epidural glutamate infusion in rats.[J]. Surgical Neurology International, 2013, 4: 106. DOI: 10.4103/2152-7806.116791
(AS)-ALPHA-AMINO-3-[(4-CARBOXYPHENYL)METHYL]-3,4-DIHYDRO-5-IODO-2,4-DIOXO-1(2H)-PYRIMIDINEPROPANOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
(AS)-ALPHA-AMINO-3-[(4-CARBOXYPHENYL)METHYL]-3,4-DIHYDRO-5-IODO-2,4-DIOXO-1(2H)-PYRIMIDINEPROPANOIC ACID Suppliers
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