1H-Indole-7-carboxylic acid, 4-chloro-
- Product Name
- 1H-Indole-7-carboxylic acid, 4-chloro-
- CAS No.
- 875305-77-4
- Chemical Name
- 1H-Indole-7-carboxylic acid, 4-chloro-
- Synonyms
- 4-Chloro-1H-indole-7-carboxylic acid;1H-Indole-7-carboxylic acid, 4-chloro-
- CBNumber
- CB92607066
- Molecular Formula
- C9H6ClNO2
- Formula Weight
- 195.6
- MOL File
- 875305-77-4.mol
1H-Indole-7-carboxylic acid, 4-chloro- Property
- Boiling point:
- 447.1±25.0 °C(Predicted)
- Density
- 1.548±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.54±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- OR949059
- Product name
- 4-Chloro-1H-indole-7-carboxylicacid
- Purity
- 97%
- Packaging
- 100mg
- Price
- $210
- Updated
- 2021/12/16
- Product number
- 3874AC
- Product name
- 4-Chloro-1H-indole-7-carboxylicacid
- Packaging
- 100mg
- Price
- $259
- Updated
- 2021/12/16
- Product number
- OR949059
- Product name
- 4-Chloro-1H-indole-7-carboxylicacid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $395
- Updated
- 2021/12/16
- Product number
- HCH0365902
- Product name
- 4-CHLORO-1H-INDOLE-7-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.22
- Updated
- 2021/12/16
- Product number
- OR949059
- Product name
- 4-Chloro-1H-indole-7-carboxylicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $895
- Updated
- 2021/12/16
1H-Indole-7-carboxylic acid, 4-chloro- Chemical Properties,Usage,Production
Synthesis
124-38-9
126811-29-8
875305-77-4
The general procedure for the synthesis of 4-chloro-1H-indole-7-carboxylic acid from carbon dioxide and 4-chloro-7-bromoindole was as follows: 560 mg (2.43 mmol) of 7-bromo-4-chloro-1H-indole was dissolved in 15 mL of tetrahydrofuran (THF). The reaction mixture was cooled to -78 °C under nitrogen protection and 4.55 mL of 1.6 M butyllithium hexane solution was slowly added, controlling the temperature to not exceed -70 °C. After the addition was completed, the reaction mixture was kept stirred at -78 °C for 30 minutes. Subsequently, the reaction mixture was warmed to 0 to 5 °C and stirring was continued. The reaction mixture was again cooled to -78°C and dry ice was added. After the reaction mixture naturally warmed to room temperature, it was stirred for 15 minutes and then poured into 100 mL of water. The aqueous phase was washed twice with ether, acidified with 1 N aqueous hydrochloric acid and then extracted twice with ether. The organic phases were combined, washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate, filtered and the solvent was concentrated under reduced pressure. The crude product was stirred with hexane for 15 min, filtered and dried to give 319 mg (67% yield) of 4-chloro-1H-indole-7-carboxylic acid as an off-white solid. Mass spectrometry (ISP) showed m/z 194.1 ([M-H]-).
References
[1] Patent: US2006/30613, 2006, A1. Location in patent: Page/Page column 35
1H-Indole-7-carboxylic acid, 4-chloro- Preparation Products And Raw materials
Raw materials
Preparation Products
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