ChemicalBook > CAS DataBase List > 2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride

2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride

Product Name
2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride
CAS No.
587870-77-7
Chemical Name
2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride
Synonyms
ABT-724 (hydrochloride);2-((4-(Pyridin-2-yl)piperazin-1-yl)methyl)-1H-benzo[d]imidazole trihydrochloride;Inhibitor,Dopamine Receptor,penile,inhibit,potentiation,side-effect,ABT-724 trihydrochloride,Dopamine,D4-receptor,ABT 724 trihydrochloride,erection
CBNumber
CB92609611
Molecular Formula
C17H22Cl3N5
Formula Weight
402.74908
MOL File
587870-77-7.mol
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2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride Property

storage temp. 
2-8°C
solubility 
H2O: >30mg/mL
form 
powder
color 
white
Water Solubility 
Soluble to 100 mM in water
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A5111
Product name
ABT-724 trihydrochloride
Purity
≥98% (HPLC)
Packaging
25mg
Price
$378
Updated
2024/03/01
Sigma-Aldrich
Product number
A5111
Product name
ABT-724 trihydrochloride
Purity
≥98% (HPLC)
Packaging
5mg
Price
$107
Updated
2022/05/15
Cayman Chemical
Product number
29506
Product name
ABT-724 (hydrochloride)
Packaging
5mg
Price
$51
Updated
2024/03/01
Cayman Chemical
Product number
29506
Product name
ABT-724 (hydrochloride)
Packaging
10mg
Price
$87
Updated
2024/03/01
TRC
Product number
A112618
Product name
ABT-724 trihydrochloride
Packaging
1mg
Price
$100
Updated
2021/12/16
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2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride Chemical Properties,Usage,Production

Description

ABT-724 is a dopamine D4 receptor agonist with an EC50 value of 12.4 nM in a FLIPR calcium flux assay using HEK293 cells expressing the human D4.4 receptor and Gαqo5. It is selective for dopamine D4 over D2 receptors at 10 μM. ABT-724 (0.03 μmol/kg) induces penile erections in 77% of male rats. It decreases mounting frequency and ejaculation latency and increases ejaculation frequency and copulatory efficacy in male rats when administered at a dose of 0.04 mg/kg. ABT-724 (0.16 and 0.64 mg/kg) decreases hyperactivity and exploratory behavior in the open field test in an adolescent spontaneously hypertensive rat (SHR) model of attention-deficit hyperactivity disorder (ADHD).

storage

+4°C (desiccate)

References

[1]. sarkar c, das s, chakroborty d, et al. cutting edge: stimulation of dopamine d4 receptors induce t cell quiescence by up-regulating kruppel-like factor-2 expression through inhibition of erk1/erk2 phosphorylation. j immunol, 2006, 177(11):7525-9.
[2]. melis mr, succu s, mascia ms, et al. pd-168077, a selective dopamine d4 receptor agonist, induces penile erection when injected into the paraventricular nucleus of male rats. neurosci lett, 2005, 379(1):59-62.
[3]. sanna f, contini a, melis mr, et al. role of dopamine d4 receptors in copulatory behavior: studies with selective d4 agonists and antagonists in male rats. pharmacol biochem behav, 2015, 137:110-8.
[4]. arranz m, collier d, sodhi m, et al. association between clozapine response and allelic variation in 5-ht2a receptor gene. lancet, 1995, 346(8970):281-2.
[5]. boehmler w, carr t, thisse c, et al. d4 dopamine receptor genes of zebrafish and effects of the antipsychotic clozapine on larval swimming behaviour. genes brain behav, 2007, 6(2):155-66.

2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride Suppliers

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587870-77-7, 2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochlorideRelated Search:


  • 2-((4-(Pyridin-2-yl)piperazin-1-yl)methyl)-1H-benzo[d]imidazole trihydrochloride
  • ABT-724 (hydrochloride)
  • Inhibitor,Dopamine Receptor,penile,inhibit,potentiation,side-effect,ABT-724 trihydrochloride,Dopamine,D4-receptor,ABT 724 trihydrochloride,erection
  • 587870-77-7