ChemicalBook > CAS DataBase List > 2-Methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione 1-[O-(2-methylbenzoyl)oxime]

2-Methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione 1-[O-(2-methylbenzoyl)oxime]

Product Name
2-Methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione 1-[O-(2-methylbenzoyl)oxime]
CAS No.
321688-88-4
Chemical Name
2-Methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione 1-[O-(2-methylbenzoyl)oxime]
Synonyms
Poloxin;Poloxin, 10 mM in DMSO;Polo-like Kinase Inhibitor V, Poloxin;Poloxin,Inhibitor,Polo-like Kinase (PLK),inhibit;Polo-like Kinase Inhibitor V, Poloxin - CAS 321688-88-4 - Calbiochem;2-Isopropyl-5-methyl-4-(((2-methylbenzoyl)oxy)imino)cyclohexa-2,5-dien-1-one;(Z)-2-Isopropyl-5-methyl-4-(((2-methylbenzoyl)oxy)imino)cyclohexa-2,5-dienone;2-Methyl-5-(1-methylethyl)-1-[O-(2-methylbenzoyl)oxime]-2,5-Cyclohexadiene-1,4-dione;2-Methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione 1-[O-(2-methylbenzoyl)oxime];2,5-Cyclohexadiene-1,4-dione, 2-methyl-5-(1-methylethyl)-, 1-[O-(2-methylbenzoyl)oxime]
CBNumber
CB92614336
Molecular Formula
C18H19NO3
Formula Weight
297.35
MOL File
321688-88-4.mol
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2-Methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione 1-[O-(2-methylbenzoyl)oxime] Property

Boiling point:
418.6±55.0 °C(Predicted)
Density 
1.11
storage temp. 
2-8°C
solubility 
DMSO: soluble5mg/mL (clear solution, warmed)
form 
Yellow solid
color 
white to beige
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Safety

Hazard Codes 
Xi,N
Risk Statements 
43-50
Safety Statements 
36/37-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
528884
Product name
Polo-like Kinase Inhibitor V, Poloxin
Packaging
5mg
Price
$187
Updated
2024/03/01
TRC
Product number
P688045
Product name
Poloxin
Packaging
50mg
Price
$235
Updated
2021/12/16
Usbiological
Product number
462769
Product name
Poloxin
Packaging
5mg
Price
$305
Updated
2021/12/16
ApexBio Technology
Product number
A3732
Product name
Poloxin
Packaging
10mg
Price
$55
Updated
2021/12/16
ApexBio Technology
Product number
A3732
Product name
Poloxin
Packaging
10mM(in 1mL DMSO)
Price
$60
Updated
2021/12/16
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2-Methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione 1-[O-(2-methylbenzoyl)oxime] Chemical Properties,Usage,Production

Uses

Poloxin is a non-ATP competitive Polo-like Kinase 1 (Plk1) inhibitor that targets the polo-box domain.

in vivo

Poloxin (40 mg/kg) decreases the proliferation of MDA-MB-231 cells, and surpresses the growth of the tumor nude mice bearing established xenografts of MDA-MB-231[1].

IC 50

PLK1 PBD: 4.8 μM (IC50); PLK2 PBD: 18.7 μM (IC50); PLK3 PBD: 53.9 μM (IC50)

2-Methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione 1-[O-(2-methylbenzoyl)oxime] Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione 1-[O-(2-methylbenzoyl)oxime] Suppliers

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321688-88-4, 2-Methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione 1-[O-(2-methylbenzoyl)oxime]Related Search:

Ethylcyclohexane Toluene diisocyanate Dimedone 1-Cyclohexylethanol Cyclohexanol CYCLOHEXYL VINYL ETHER

  • 2-Methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione 1-[O-(2-methylbenzoyl)oxime]
  • Poloxin
  • 2-Methyl-5-(1-methylethyl)-1-[O-(2-methylbenzoyl)oxime]-2,5-Cyclohexadiene-1,4-dione
  • (Z)-2-Isopropyl-5-methyl-4-(((2-methylbenzoyl)oxy)imino)cyclohexa-2,5-dienone
  • Polo-like Kinase Inhibitor V, Poloxin
  • Polo-like Kinase Inhibitor V, Poloxin - CAS 321688-88-4 - Calbiochem
  • 2,5-Cyclohexadiene-1,4-dione, 2-methyl-5-(1-methylethyl)-, 1-[O-(2-methylbenzoyl)oxime]
  • 2-Isopropyl-5-methyl-4-(((2-methylbenzoyl)oxy)imino)cyclohexa-2,5-dien-1-one
  • Poloxin,Inhibitor,Polo-like Kinase (PLK),inhibit
  • Poloxin, 10 mM in DMSO
  • 321688-88-4