5-Bromo-2,3-difluorobenzonitrile
- Product Name
- 5-Bromo-2,3-difluorobenzonitrile
- CAS No.
- 1105665-42-6
- Chemical Name
- 5-Bromo-2,3-difluorobenzonitrile
- Synonyms
- 5-Bromo-2,3-difluorobenzonitrile;Benzonitrile, 5-broMo-2,3-difluoro-;5-Bromo-2,3-difluorobenzonitrile 5-Bromo-2,3-difluorobenzonitrile
- CBNumber
- CB92614664
- Molecular Formula
- C7H2BrF2N
- Formula Weight
- 218
- MOL File
- 1105665-42-6.mol
5-Bromo-2,3-difluorobenzonitrile Property
- Boiling point:
- 215.6±35.0 °C(Predicted)
- Density
- 1.77±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Off-white to light yellow Solid
Safety
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- B997965
- Product name
- 5-Bromo-2,3-difluorobenzonitrile
- Packaging
- 50mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- PC501971
- Product name
- 5-Bromo-2,3-difluorobenzonitrile
- Purity
- 95%
- Packaging
- 250mg
- Price
- $129
- Updated
- 2021/12/16
- Product number
- 3637-B-17
- Product name
- 5-Bromo-2,3-difluorobenzonitrile
- Packaging
- 250mg
- Price
- $170
- Updated
- 2021/12/16
- Product number
- PC501971
- Product name
- 5-Bromo-2,3-difluorobenzonitrile
- Purity
- 95%
- Packaging
- 1g
- Price
- $385
- Updated
- 2021/12/16
- Product number
- 3637-B-17
- Product name
- 5-Bromo-2,3-difluorobenzonitrile
- Packaging
- 1g
- Price
- $512
- Updated
- 2021/12/16
5-Bromo-2,3-difluorobenzonitrile Chemical Properties,Usage,Production
Synthesis
1247885-41-1
1105665-42-6
The general procedure for the synthesis of 5-bromo-2,3-difluorobenzonitrile using 5-amino-2,3-difluorobenzonitrile as starting material was as follows: first, copper (I) bromide (25 mg, 0.11 mmol) was dissolved in acetonitrile (1 mL) under nitrogen protection and the solution was cooled down to 0 °C. Subsequently, a solution of tert-butyl nitrite (15 mg, 0.14 mmol) and 5-amino-2,3-difluorobenzonitrile (14 mg, 0.090 mmol) in acetonitrile (1 mL) was added sequentially to this solution. The reaction mixture was stirred at room temperature for 6 hours. Upon completion of the reaction, the solvent was removed by vacuum rotary evaporation. The residue was extracted by partitioning with ethyl acetate (5 mL) and saturated aqueous sodium bicarbonate solution (5 mL). The organic layer was separated, dried over anhydrous sodium sulfate and concentrated to give 5-bromo-2,3-difluorobenzonitrile (18 mg, 93% yield) as a yellow solid. The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.48-7.45 (m, 1H), 7.38-7.27 (m, 1H); LC/MS analysis showed m/e = 218 (M + H)+.
References
[1] Patent: WO2010/114971, 2010, A1. Location in patent: Page/Page column 237
[2] Patent: US2016/376283, 2016, A1. Location in patent: Paragraph 0271; 0274
5-Bromo-2,3-difluorobenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromo-2,3-difluorobenzonitrile manufacturers
- Product
- 5-Bromo-2,3-difluorobenzonitrile 1105665-42-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-10