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5-Bromo-2,3-difluorobenzonitrile

Product Name
5-Bromo-2,3-difluorobenzonitrile
CAS No.
1105665-42-6
Chemical Name
5-Bromo-2,3-difluorobenzonitrile
Synonyms
5-Bromo-2,3-difluorobenzonitrile;Benzonitrile, 5-broMo-2,3-difluoro-;5-Bromo-2,3-difluorobenzonitrile 5-Bromo-2,3-difluorobenzonitrile
CBNumber
CB92614664
Molecular Formula
C7H2BrF2N
Formula Weight
218
MOL File
1105665-42-6.mol
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5-Bromo-2,3-difluorobenzonitrile Property

Boiling point:
215.6±35.0 °C(Predicted)
Density 
1.77±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
Appearance
Off-white to light yellow Solid
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Safety

HS Code 
2926907090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
B997965
Product name
5-Bromo-2,3-difluorobenzonitrile
Packaging
50mg
Price
$110
Updated
2021/12/16
Apolloscientific
Product number
PC501971
Product name
5-Bromo-2,3-difluorobenzonitrile
Purity
95%
Packaging
250mg
Price
$129
Updated
2021/12/16
SynQuest Laboratories
Product number
3637-B-17
Product name
5-Bromo-2,3-difluorobenzonitrile
Packaging
250mg
Price
$170
Updated
2021/12/16
Apolloscientific
Product number
PC501971
Product name
5-Bromo-2,3-difluorobenzonitrile
Purity
95%
Packaging
1g
Price
$385
Updated
2021/12/16
SynQuest Laboratories
Product number
3637-B-17
Product name
5-Bromo-2,3-difluorobenzonitrile
Packaging
1g
Price
$512
Updated
2021/12/16
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5-Bromo-2,3-difluorobenzonitrile Chemical Properties,Usage,Production

Synthesis

1247885-41-1

1105665-42-6

The general procedure for the synthesis of 5-bromo-2,3-difluorobenzonitrile using 5-amino-2,3-difluorobenzonitrile as starting material was as follows: first, copper (I) bromide (25 mg, 0.11 mmol) was dissolved in acetonitrile (1 mL) under nitrogen protection and the solution was cooled down to 0 °C. Subsequently, a solution of tert-butyl nitrite (15 mg, 0.14 mmol) and 5-amino-2,3-difluorobenzonitrile (14 mg, 0.090 mmol) in acetonitrile (1 mL) was added sequentially to this solution. The reaction mixture was stirred at room temperature for 6 hours. Upon completion of the reaction, the solvent was removed by vacuum rotary evaporation. The residue was extracted by partitioning with ethyl acetate (5 mL) and saturated aqueous sodium bicarbonate solution (5 mL). The organic layer was separated, dried over anhydrous sodium sulfate and concentrated to give 5-bromo-2,3-difluorobenzonitrile (18 mg, 93% yield) as a yellow solid. The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.48-7.45 (m, 1H), 7.38-7.27 (m, 1H); LC/MS analysis showed m/e = 218 (M + H)+.

References

[1] Patent: WO2010/114971, 2010, A1. Location in patent: Page/Page column 237
[2] Patent: US2016/376283, 2016, A1. Location in patent: Paragraph 0271; 0274

5-Bromo-2,3-difluorobenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Bromo-2,3-difluorobenzonitrile Suppliers

China 50 India 1 United Kingdom 1 United States 5 Global 57
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
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United States
ProdList
57505
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58
Aceschem Inc.
Tel
+1-817863-6948 +1-（817）863-6948
Email
sales@aceschem.com
Country
United States
ProdList
19632
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58
Synthonix Inc
Tel
--
Fax
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Email
info@synthonix.com
Country
United States
ProdList
6872
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58
Combi-Blocks Inc.
Tel
--
Fax
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Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
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View Lastest Price from 5-Bromo-2,3-difluorobenzonitrile manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
5-Bromo-2,3-difluorobenzonitrile 1105665-42-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-10

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