EPZ004777
- Product Name
- EPZ004777
- CAS No.
- 1338466-77-5
- Chemical Name
- EPZ004777
- Synonyms
- PEZ4777;CS-1932;EPZ 4777;EPZ-4777;EPZ004777;EPZ004777 USP/EP/BP;EPZ 004777;EPZ-004777;EPZ004777 (formic acid salt);DOT1L Inhibitor EPZ004777 EPZ-004777;EPZ004777; EPZ 004777; EPZ-004777;PEZ4777;EPZ 4777;EPZ-4777
- CBNumber
- CB92614846
- Molecular Formula
- C28H41N7O4
- Formula Weight
- 539.67
- MOL File
- 1338466-77-5.mol
EPZ004777 Property
- Boiling point:
- 740.7±60.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥27 mg/mL in DMSO; insoluble in H2O; ≥94.6 mg/mL in EtOH with ultrasonic
- form
- solid
- pka
- 12.51±0.70(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 16173
- Product name
- EPZ004777 (formic acid salt)
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $25
- Updated
- 2021/12/16
- Product number
- 16173
- Product name
- EPZ004777 (formic acid salt)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 16173
- Product name
- EPZ004777 (formic acid salt)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 16173
- Product name
- EPZ004777 (formic acid salt)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $235
- Updated
- 2021/12/16
- Product number
- 5567
- Product name
- EPZ004777
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $279
- Updated
- 2021/12/16
EPZ004777 Chemical Properties,Usage,Production
Uses
EPZ 004777 is potent small molecule inhibitor of protein lysine methyltransferase DOT1L.
Definition
ChEBI: 1-[3-[[(2R,3S,4R,5R)-5-(4-amino-7-pyrrolo[2,3-d]pyrimidinyl)-3,4-dihydroxy-2-oxolanyl]methyl-propan-2-ylamino]propyl]-3-(4-tert-butylphenyl)urea is a N-glycosyl compound.
Biological Activity
epz004777 is a specific small-molecule h3k79 methyltransferase dot1l inhibitor that potently inhibits dot1l in a radionuclide homogeneous assay with the half maximal inhibition concentration ic50 value of 400 pm and selectively kills a variety of mll-rearranged leukemia cells, including an mll-af4 leukemia cell line mv4-11 and an mll-af9 leukemia cell line molm13 [1 & 2].epz004777 has also been found to selectively inhibit the proliferation of mll-af10 and calm-af10 transformed cells in a dose dependent manner (ic50: 0.1 μm to 1 μm), in which the mrna expression levels of two hallmark leukemogenic genes (hoxa9 and meis1) are suppressed by epz004777 in a concentration dependent manner [2].
storage
Store at -20°C
EPZ004777 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from EPZ004777 manufacturers
- Product
- EPZ004777 1338466-77-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-02