ChemicalBook > CAS DataBase List > Exo-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride

Exo-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride

Product Name: Exo-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride
CAS No.: 17366-48-2
Chemical Name: Exo-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride
Synonyms: Nortropine Impurity;Nortropine Impurity 1 HCl;Nortropine Impurity 2 HCl;Exo-3-hydroxy-8-azabicycl...;EXO-3-HYDROXY-8-AZABICYCLO[3.2.1]OCTANE HCL;exo-8-Azabicyclo[3.2.1]octan-3-ol hydrochloride;(3-exo)-8-Azabicyclo[3.2.1]octan-3-ol hydrochloride;Exo-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride;rel-(1R,5S)-8-azabicyclo[3.2.1]octan-3-ol hydrochloride;8-Azabicyclo[3.2.1]octan-3-ol, hydrochloride (1:1), (3-exo)-
CBNumber: CB92615292
Molecular Formula: C7H14ClNO
Formula Weight: 163.64516
MOL File: 17366-48-2.mol

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Exo-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride Property

Melting point:: 200 °C
storage temp.: Inert atmosphere,Room Temperature
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H313May be harmful in contact with skin

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0049365
Product name: exo-3-Hydroxy-8-azabicyclo[3.2.1]octanehydrochloride
Packaging: 1g
Price: $158
Updated: 2021/12/16

Matrix Scientific

Product number: 112099
Product name: exo-3-Hydroxy-8-azabicyclo-[3.2.1]octane hydrochloride
Packaging: 1g
Price: $227
Updated: 2021/12/16

AK Scientific

Product number: 3938CZ
Product name: Exo-3-hydroxy-8-azabicyclo[3.2.1]octanehydrochloride
Packaging: 1g
Price: $231
Updated: 2021/12/16

ChemScene

Product number: CS-0049365
Product name: exo-3-Hydroxy-8-azabicyclo[3.2.1]octanehydrochloride
Packaging: 5g
Price: $473
Updated: 2021/12/16

Matrix Scientific

Product number: 112099
Product name: exo-3-Hydroxy-8-azabicyclo-[3.2.1]octane hydrochloride
Packaging: 5g
Price: $607
Updated: 2021/12/16

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Exo-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride Chemical Properties,Usage,Production

Synthesis

194222-05-4

17366-48-2

Step 1. Preparation of (1R,3S,5S)-8-azabicyclo[3.2.1]octan-3-ol hydrochloride: tert-butyl (1R,3S,5S)-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate (300 mg, 1.32 mmol) was dissolved in a solution of 1,4-dioxane (4.0 mL) in 4 M HCl and the reaction was stirred at room temperature for 15 hours. After completion of the reaction, the mixture was concentrated under reduced pressure to give the target product (168 mg, quantitative yield) as a white solid, which could be used in subsequent steps without further purification.LC-MS analysis: calculated value 127.1 [M + H]+, measured value 127.90 [M + H]+.

References

[1] Patent: US2012/53180, 2012, A1. Location in patent: Page/Page column 35
[2] Patent: WO2013/61305, 2013, A1. Location in patent: Page/Page column 44

Exo-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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17366-48-2