DOV 21947 hydrochloride
- Product Name
- DOV 21947 hydrochloride
- CAS No.
- 410074-74-7
- Chemical Name
- DOV 21947 hydrochloride
- Synonyms
- EB 1010 (Hydrochloride);DOV 21947 hydrochloride;AMitifadine hydrochloride;DOV-21947 HYDROCHLORIDE;EB-1010 HYDROCHLORIDE;DOV 21947 hydrochloride(Amitifadine hydrochloride);(1R,5S)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE HYDROCHLORIDE
- CBNumber
- CB92620700
- Molecular Formula
- C11H12Cl3N
- Formula Weight
- 264.57868
- MOL File
- 410074-74-7.mol
DOV 21947 hydrochloride Property
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 100 mg/mL (377.96 mM)
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-4638
- Product name
- Amitifadinehydrochloride
- Purity
- 99.92%
- Packaging
- 10mg
- Price
- $600
- Updated
- 2021/12/16
- Product number
- orb611878
- Product name
- Amitifadine hydrochloride
- Purity
- >98%
- Packaging
- 10mg
- Price
- $734.4
- Updated
- 2021/12/16
- Product number
- CS-4638
- Product name
- Amitifadinehydrochloride
- Purity
- 99.92%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-4638
- Product name
- Amitifadinehydrochloride
- Purity
- 99.92%
- Packaging
- 50mg
- Price
- $1800
- Updated
- 2021/12/16
- Product number
- orb611878
- Product name
- Amitifadine hydrochloride
- Purity
- >98%
- Packaging
- 50mg
- Price
- $2157.3
- Updated
- 2021/12/16
DOV 21947 hydrochloride Chemical Properties,Usage,Production
Biological Activity
Amitifadine hydrochloride is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) with IC50 values of 12, 23, and 96 nM in HEK 293 cells, respectively.
in vitro
Amitifadine (DOV 21,947) is an antidepressant drug. K i values for SERT, NET, and DAT are 99 nM, 262 nM, and 213 nM. The IC 50 values for serotonin, norepinephrine and dopamine uptake are 12, 23 and 96 nM, respectively.
in vivo
The 30 mg/kg Amitifadine dose significantly reduces nicotine self-administration. The 5 and 10 mg/kg doses reduce nicotine self-administration during the first 15 min. of the session when the greatest amount of nicotine is self -administered. The 30 mg/kg Amitifadine dose, but not the lower doses cause a significant reduction in locomotor activity averaged over the 1-hour session and reduce food motivated responding. The 10 mg/kg dose causes hypoactivity at the beginning of the session , but 5 mg/kg does not cause any hypoactivity. The effect of chronic Amitifadine treatment (10 mg/kg) over the course of 15 sessions is also determined. Amitifadine causes a significant reduction in nicotine self-administration, which is not seen to diminish over two consecutive weeks of treatment and a week after enforced abstinence. Amitifadine significantly reduces nicotine self-administration. This prompts further research to determine if Amitifadine might be an effective treatment for smokin g cessation.
target
IC50: 12 nM (serotonin), 23 nM (norepinephrine), 96 nM (dopamine).
DOV 21947 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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