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Daun02

Product Name
Daun02
CAS No.
290304-24-4
Chemical Name
Daun02
Synonyms
Daun02;DAUN 02; DAUN-02;5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-[[[[4-(β-D-galactopyranosyloxy)-3-nitrophenyl]methoxy]carbonyl]amino]-α-L-lyxo-hexopyranosyl]oxy]-, (8S,10S)-;(8S,10S)-8-Acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-[[[[4-(beta-D-galactopyranosyloxy)-3-nitrophenyl]methoxy]carbonyl]amino]-alpha-L-lyxo-hexopyranosyl]oxy]-5,12-naphthacenedione
CBNumber
CB92624122
Molecular Formula
C41H44N2O20
Formula Weight
884.79
MOL File
290304-24-4.mol
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Daun02 Property

Boiling point:
1128.4±65.0 °C(Predicted)
Density 
1.67±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; insoluble in EtOH; ≥17.92 mg/mL in DMSO with ultrasonic
form 
Powder
pka
7.39±0.60(Predicted)
color 
Brown to wine
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0464
Product name
Daun02
Purity
98.85%
Packaging
2mg
Price
$216
Updated
2021/12/16
ChemScene
Product number
CS-0464
Product name
Daun02
Purity
98.85%
Packaging
5mg
Price
$290
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0013873
Product name
DAUN-02
Purity
95.00%
Packaging
5MG
Price
$490.6
Updated
2021/12/16
ApexBio Technology
Product number
A3352
Product name
Daun02
Packaging
10mg
Price
$499
Updated
2021/12/16
ChemScene
Product number
CS-0464
Product name
Daun02
Purity
98.85%
Packaging
10mg
Price
$528
Updated
2021/12/16
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Daun02 Chemical Properties,Usage,Production

Biological Activity

daun02 is an inhibitor of cell viability with ic50 values of 1.5μm, 3.5μm and 0.5μm, respectively in panc02, mcf-7 and t47-d cell lines [1].daun02, an anthracycline derivative, is a substrate of β-galactosidase. β-galactosidase catalyses daun02 into daunomycin, which causes apoptotic cell death and blockade of voltagedependent calcium channels. daun02 has been used in the study of suicide gene therapy which has thepotential to increase the selective toxicityof conventional antitumor agents. in this study, daun02 is shown to suppress the viability of several β-gal gene transduced tumor celllinesin vitro. however, none of thetumors responded to treatment withdaun02in vivo. this mayhave been due tothe limited aqueous solubilityof the agent.daun02 is also used to study activated neuronal ensembles in models of conditioned drug effects and relapse. the method is called daun02 inactivation method. in the fos–lacz transgenic rats, the previously drug activated neurons can be inactivated through injection of the prodrug daun02 [1,2].carl r. lupica, yavinshaham and bruce t. hope.new technologies for examining the role of neuronal ensembles in drug addiction and fear.nature reviews/neuroscience. 2013, 14: 743-754.

in vitro

Daun02 is a prodrug, which is converted by β-galactosidase to Daunorubicin, which has been shown to reduce calcium ion (Ca 2+ )-dependent action potentials in neuroblastoma cells. Daunorubicin is a topoisomerase inhibitor.It is a good substrate for β-galactosidase (β-gal). The concentration of Daun02 producing 50% (EC 50 ) decrease in cell viability is 0.5 μM, 1.5 μM, and 3.5 μM for T47-D, Panc02, and MCF-7, respectively.

in vivo

Daun02 is a good substrate for β-gal with K m and V max values of 0.37 mM and 8.6 μmol/min/mg protein. At a concentration of 10 -5 M, Daun02 is 79% bound to plasma protein compares to 94% for Daunomycin.

target

Panc02

References

[1] david farquhar, bih fang pan, mamoru sakurai, ajitghosh, craig a. mullen, j. arly nelson. suicide gene therapy using e.coliβ-galactosidase. cancer chemotherpharmacol.2002, 50: 65–70.
[2] fabio c. cruz, eisukekoya, danielle h. guez-barber, jennifer m. bossert,

Daun02 Preparation Products And Raw materials

Raw materials

Preparation Products

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Daun02 Suppliers

China 50 United States 7 Global 57
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
17687
Advantage
55
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52693
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58

290304-24-4, Daun02Related Search:


  • Daun02
  • (8S,10S)-8-Acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-[[[[4-(beta-D-galactopyranosyloxy)-3-nitrophenyl]methoxy]carbonyl]amino]-alpha-L-lyxo-hexopyranosyl]oxy]-5,12-naphthacenedione
  • DAUN 02; DAUN-02
  • 5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-[[[[4-(β-D-galactopyranosyloxy)-3-nitrophenyl]methoxy]carbonyl]amino]-α-L-lyxo-hexopyranosyl]oxy]-, (8S,10S)-
  • 290304-24-4
  • C41H44N2O20