Daun02

Product Name: Daun02
CAS No.: 290304-24-4
Chemical Name: Daun02
Synonyms: Daun02;DAUN 02; DAUN-02;5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-[[[[4-(β-D-galactopyranosyloxy)-3-nitrophenyl]methoxy]carbonyl]amino]-α-L-lyxo-hexopyranosyl]oxy]-, (8S,10S)-;(8S,10S)-8-Acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-[[[[4-(beta-D-galactopyranosyloxy)-3-nitrophenyl]methoxy]carbonyl]amino]-alpha-L-lyxo-hexopyranosyl]oxy]-5,12-naphthacenedione
CBNumber: CB92624122
Molecular Formula: C41H44N2O20
Formula Weight: 884.79
MOL File: 290304-24-4.mol

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Daun02 Property

Boiling point:: 1128.4±65.0 °C(Predicted)
Density: 1.67±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥17.92 mg/mL in DMSO with ultrasonic
form: Powder
pka: 7.39±0.60(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0464
Product name: Daun02
Purity: 98.85%
Packaging: 5mg
Price: $290
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0013873
Product name: DAUN-02
Purity: 95.00%
Packaging: 5MG
Price: $490.6
Updated: 2021/12/16

ApexBio Technology

Product number: A3352
Product name: Daun02
Packaging: 10mg
Price: $499
Updated: 2021/12/16

ChemScene

Product number: CS-0464
Product name: Daun02
Purity: 98.85%
Packaging: 10mg
Price: $528
Updated: 2021/12/16

ApexBio Technology

Product number: A3352
Product name: Daun02
Packaging: 25mg
Price: $835
Updated: 2021/12/16

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Daun02 Chemical Properties,Usage,Production

Biological Activity

daun02 is an inhibitor of cell viability with ic50 values of 1.5μm, 3.5μm and 0.5μm, respectively in panc02, mcf-7 and t47-d cell lines [1].daun02, an anthracycline derivative, is a substrate of β-galactosidase. β-galactosidase catalyses daun02 into daunomycin, which causes apoptotic cell death and blockade of voltagedependent calcium channels. daun02 has been used in the study of suicide gene therapy which has thepotential to increase the selective toxicityof conventional antitumor agents. in this study, daun02 is shown to suppress the viability of several β-gal gene transduced tumor celllinesin vitro. however, none of thetumors responded to treatment withdaun02in vivo. this mayhave been due tothe limited aqueous solubilityof the agent.daun02 is also used to study activated neuronal ensembles in models of conditioned drug effects and relapse. the method is called daun02 inactivation method. in the fos–lacz transgenic rats, the previously drug activated neurons can be inactivated through injection of the prodrug daun02 [1,2].carl r. lupica, yavinshaham and bruce t. hope.new technologies for examining the role of neuronal ensembles in drug addiction and fear.nature reviews/neuroscience. 2013, 14: 743-754.

in vitro

Daun02 is a prodrug, which is converted by β-galactosidase to Daunorubicin, which has been shown to reduce calcium ion (Ca ²⁺ )-dependent action potentials in neuroblastoma cells. Daunorubicin is a topoisomerase inhibitor.It is a good substrate for β-galactosidase (β-gal). The concentration of Daun02 producing 50% (EC ₅₀ ) decrease in cell viability is 0.5 μM, 1.5 μM, and 3.5 μM for T47-D, Panc02, and MCF-7, respectively.

in vivo

Daun02 is a good substrate for β-gal with K _m and V _max values of 0.37 mM and 8.6 μmol/min/mg protein. At a concentration of 10 ^-5 M, Daun02 is 79% bound to plasma protein compares to 94% for Daunomycin.

target

Panc02

References

[1] david farquhar, bih fang pan, mamoru sakurai, ajitghosh, craig a. mullen, j. arly nelson. suicide gene therapy using e.coliβ-galactosidase. cancer chemotherpharmacol.2002, 50: 65–70.
[2] fabio c. cruz, eisukekoya, danielle h. guez-barber, jennifer m. bossert,

Daun02 Preparation Products And Raw materials

Raw materials

Preparation Products

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Daun02 Suppliers

China 50 United States 7 Global 57

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
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BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
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Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
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Country: China
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Chengdu Dianchun Technology Co., Ltd

Tel: 400-1166-196 18502815961
Fax: QQ：800101999
Email: cdhxsj@163.com
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ProdList: 14623
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Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12308
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Musechem

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Shanghai Jizhi Biochemical Technology Co. Ltd.

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Country: China
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Fan De(Beijing) Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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DC Chemicals

Tel: 021-58447131 13564518121
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290304-24-4, Daun02Related Search:

Daun02

(8S,10S)-8-Acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-[[[[4-(beta-D-galactopyranosyloxy)-3-nitrophenyl]methoxy]carbonyl]amino]-alpha-L-lyxo-hexopyranosyl]oxy]-5,12-naphthacenedione

DAUN 02; DAUN-02

5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-[[[[4-(β-D-galactopyranosyloxy)-3-nitrophenyl]methoxy]carbonyl]amino]-α-L-lyxo-hexopyranosyl]oxy]-, (8S,10S)-

290304-24-4

C41H44N2O20