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Daun02

Product Name
Daun02
CAS No.
290304-24-4
Chemical Name
Daun02
Synonyms
Daun02;DAUN 02; DAUN-02;5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-[[[[4-(β-D-galactopyranosyloxy)-3-nitrophenyl]methoxy]carbonyl]amino]-α-L-lyxo-hexopyranosyl]oxy]-, (8S,10S)-;(8S,10S)-8-Acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-[[[[4-(beta-D-galactopyranosyloxy)-3-nitrophenyl]methoxy]carbonyl]amino]-alpha-L-lyxo-hexopyranosyl]oxy]-5,12-naphthacenedione
CBNumber
CB92624122
Molecular Formula
C41H44N2O20
Formula Weight
884.79
MOL File
290304-24-4.mol
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Daun02 Property

Boiling point:
1128.4±65.0 °C(Predicted)
Density 
1.67±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; insoluble in EtOH; ≥17.92 mg/mL in DMSO with ultrasonic
form 
Powder
pka
7.39±0.60(Predicted)
color 
Brown to wine
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0464
Product name
Daun02
Purity
98.85%
Packaging
2mg
Price
$216
Updated
2021/12/16
ChemScene
Product number
CS-0464
Product name
Daun02
Purity
98.85%
Packaging
5mg
Price
$290
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0013873
Product name
DAUN-02
Purity
95.00%
Packaging
5MG
Price
$490.6
Updated
2021/12/16
ApexBio Technology
Product number
A3352
Product name
Daun02
Packaging
10mg
Price
$499
Updated
2021/12/16
ChemScene
Product number
CS-0464
Product name
Daun02
Purity
98.85%
Packaging
10mg
Price
$528
Updated
2021/12/16
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Daun02 Chemical Properties,Usage,Production

Biological Activity

daun02 is an inhibitor of cell viability with ic50 values of 1.5μm, 3.5μm and 0.5μm, respectively in panc02, mcf-7 and t47-d cell lines [1].daun02, an anthracycline derivative, is a substrate of β-galactosidase. β-galactosidase catalyses daun02 into daunomycin, which causes apoptotic cell death and blockade of voltagedependent calcium channels. daun02 has been used in the study of suicide gene therapy which has thepotential to increase the selective toxicityof conventional antitumor agents. in this study, daun02 is shown to suppress the viability of several β-gal gene transduced tumor celllinesin vitro. however, none of thetumors responded to treatment withdaun02in vivo. this mayhave been due tothe limited aqueous solubilityof the agent.daun02 is also used to study activated neuronal ensembles in models of conditioned drug effects and relapse. the method is called daun02 inactivation method. in the fos–lacz transgenic rats, the previously drug activated neurons can be inactivated through injection of the prodrug daun02 [1,2].carl r. lupica, yavinshaham and bruce t. hope.new technologies for examining the role of neuronal ensembles in drug addiction and fear.nature reviews/neuroscience. 2013, 14: 743-754.

in vitro

Daun02 is a prodrug, which is converted by β-galactosidase to Daunorubicin, which has been shown to reduce calcium ion (Ca 2+ )-dependent action potentials in neuroblastoma cells. Daunorubicin is a topoisomerase inhibitor.It is a good substrate for β-galactosidase (β-gal). The concentration of Daun02 producing 50% (EC 50 ) decrease in cell viability is 0.5 μM, 1.5 μM, and 3.5 μM for T47-D, Panc02, and MCF-7, respectively.

in vivo

Daun02 is a good substrate for β-gal with K m and V max values of 0.37 mM and 8.6 μmol/min/mg protein. At a concentration of 10 -5 M, Daun02 is 79% bound to plasma protein compares to 94% for Daunomycin.

target

Panc02

References

[1] david farquhar, bih fang pan, mamoru sakurai, ajitghosh, craig a. mullen, j. arly nelson. suicide gene therapy using e.coliβ-galactosidase. cancer chemotherpharmacol.2002, 50: 65–70.
[2] fabio c. cruz, eisukekoya, danielle h. guez-barber, jennifer m. bossert,

Daun02 Preparation Products And Raw materials

Raw materials

Preparation Products

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Daun02 Suppliers

China 50 United States 7 Global 57
BOC Sciences
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16314854226
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info@bocsci.com
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United States
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Musechem
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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marketing@targetmol.com
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United States
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32165
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Aladdin Scientific
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+1-+1(833)-552-7181
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sales@aladdinsci.com
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United States
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52925
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58
ApexBio Technology
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sales@apexbt.com
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United States
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6251
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Creative Enzymes
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MedChemExpress
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Country
United States
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6398
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290304-24-4, Daun02Related Search:


  • Daun02
  • (8S,10S)-8-Acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-[[[[4-(beta-D-galactopyranosyloxy)-3-nitrophenyl]methoxy]carbonyl]amino]-alpha-L-lyxo-hexopyranosyl]oxy]-5,12-naphthacenedione
  • DAUN 02; DAUN-02
  • 5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-[[[[4-(β-D-galactopyranosyloxy)-3-nitrophenyl]methoxy]carbonyl]amino]-α-L-lyxo-hexopyranosyl]oxy]-, (8S,10S)-
  • 290304-24-4
  • C41H44N2O20