GSK1120212 (DMSO solvate)

ChemicalBook > CAS DataBase List > GSK1120212 (DMSO solvate)

GSK1120212 (DMSO solvate)

Product Name: GSK1120212 (DMSO solvate)
CAS No.: 1187431-43-1
Chemical Name: GSK1120212 (DMSO solvate)
Synonyms: Trametinib dimethyl sulfoxide;154988;JTP-74057;GSK 1120212B;DMSO solvate;JTP-74057;GSK1120212;TraMetinib DMSO (API);Trametinib Impurity 28;JTP-74057 (DMSO solvate);GSK1120212 (DMSO solvate)
CBNumber: CB92624177
Molecular Formula: C28H29FIN5O5S
Formula Weight: 693.53
MOL File: 1187431-43-1.mol

Less

GSK1120212 (DMSO solvate) Property

storage temp.: Store at -20°C
solubility: insoluble in EtOH; insoluble in H2O; ≥11.2 mg/mL in DMSO with gentle warming and ultrasonic
form: solid

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H361Suspected of damaging fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

ApexBio Technology

Product number: A3887
Product name: TrametinibDMSOsolvate
Packaging: 10mM(in 1mL DMSO)
Price: $55
Updated: 2021/12/16

ChemScene

Product number: CS-0061
Product name: Trametinib(DMSOsolvate)
Purity: 99.77%
Packaging: 10mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: BISN0218
Product name: Trametinib DMSO solvate
Packaging: 5mg
Price: $68
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FT65193
Product name: GSK 1120212B
Packaging: 50mg
Price: $75
Updated: 2021/12/16

ApexBio Technology

Product number: A3887
Product name: TrametinibDMSOsolvate
Packaging: 50mg
Price: $80
Updated: 2021/12/16

Less

GSK1120212 (DMSO solvate) Chemical Properties,Usage,Production

Description

In May 2013, the US FDA approved trametinib (also referred to as GSK1120212 and JTP-74057), for the treatment of patients with unresectable or metastatic melanoma with BRAF^V600e or BRAF^V600K mutations as detected by an FDA-approved test. Extensive lead optimization led to the identification of trametinib which is a potent ATP noncompetitive inhibitor of MEK1 and MEK2 (IC₅₀ =0.7 and 0.9 nM, respectively, with initially unphosphorylated MEK). It also showed inhibitory activity in ACHN and HT-29 cancer cell lines (IC_50s of 9.8 and 0.57 nM, respectively). Consistent with its in vitro activity, trametinib showed significant antitumor activity in a KRAS^G12S A549 tumor xenograft model where near to complete tumor growth inhibition (TGI) was observed at 5.0 and 2.5 mg/kg (92% and 87% TGI, respectively). Broad antitumor activity was seen in other xenograft models as well. A synthetic route to trametinib that employs a base catalyzed rearrangement of a pyrido[2,3-d]pyrimidine core to pyrido[4,3-d]pyrimidine, as a key step has been reported.

Originator

Japan Tobacco (Japan)

Uses

Trametinib (DMSO Solvate) is a highly potent and selective MEK inhibitor with significant antitumor activity.

Definition

ChEBI: An addition compound obtained by combining equimolar amounts of trametinib and dimethyl sulfoxide. Used for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibito treatment.

brand name

Mekinist

Synthesis

Commercial 2-fluoro-4-iodoaniline (180) was sequentially subjected to CDI and cyclopropylamine to generate urea 181 in 96% yield. This was followed by coupling with cyanoacetic acid in the presence of mesyl chloride and DMF to furnish imide 182 in 96% yield. Under basic conditions, imide 182 underwent an intramolecular cyclization reaction to produce pyrimidine-2,4- dione 183 in 88% yield. Next, condensation with DMF¨CDMA generated formamidine 184 in 92% yield, and this was followed by NaBH4-mediated reduction and subsequent annulation with 2- methyl-malonic acid (186) to arrive at trione 187 in 58% from 184. Trione 187 was then treated with p-toluenesulfonyl chloride in Et3N, and the resulting tosylate was exposed to 30-aminoacetanilide (189) in the presence of 2,6-lutidine and DMA, inducing an addition-elimination reaction to give pyrido[2,3-d]pyrimidine 190 in 93% yield. The rearrangement of pyrido[2,3-d]pyrimidine 190 with sodium methoxide in THF/MeOH gave pyrido[4,3- d]pyrimidine (trametinib) in 89% yield. This was then complexed with a single equivalent of DMSO to produce trametinib DMSO (XXIV) in 92% yield.

GSK1120212 (DMSO solvate) Preparation Products And Raw materials

Raw materials

Preparation Products

Less

GSK1120212 (DMSO solvate) Suppliers

China 111 India 3 United Kingdom 2 United States 9 Global 125

Taizhou Ruixin Chemical Co., Ltd.

Tel: 0576-89085261 15867635987
Fax: 0576-89085262
Email: jasonhu09@163.com
Country: China
ProdList: 442
Advantage: 50

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696;
Email: info@hanhongsci.com
Country: China
ProdList: 42982
Advantage: 64

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9442
Advantage: 58

Shenzhen HwaGen Pharmaceutical Co.,Ltd

Tel: 0752-5538396 18927339850
Fax: 0752-5319394
Email: sales1@rafflespt.com
Country: China
ProdList: 216
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7934
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3421
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9636
Advantage: 58

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9798
Advantage: 50

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4121
Advantage: 55

Candia Pharmatech Co. , Ltd.

Tel: +86-371-55216238
Fax: +86-371-86615086
Country: China
ProdList: 286
Advantage: 60

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9254
Advantage: 55

Shanghai Shanyuan pharmaceutical technology co., LTD

Tel: 021-31761238 13167072949
Fax: 021-31761238
Email: 3146446224@qq.com
Country: China
ProdList: 1609
Advantage: 55

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3868
Advantage: 58

Lancrix Chemicals

Tel: 86-21-50817262
Fax: 86-21-57712035
Email: sales@lancrix.com
Country: China
ProdList: 1503
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2982
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 021-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 7565
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Hubei Yangxin Medical Technology Co., Ltd.

Tel: 15374522761
Fax: QQ:2853117752
Email: 3003392093@qq.com
Country: China
ProdList: 7851
Advantage: 55

Henan Anky Chemical Technology Co., Ltd.

Tel: 17836913271
Fax: 0374-8348899
Email: 3224305243@qq.com
Country: China
ProdList: 2707
Advantage: 58

Chemleader Biomedical Co., Limited.

Tel: 021-58180488
Fax: 021-58180499
Email: sales@MedChemLeader.com
Country: China
ProdList: 999
Advantage: 58

Chengdu Saiousi Pharmaceutical Co., Ltd

Tel: 028-64971018 18108168130
Fax: 86 028-64971018
Country: China
ProdList: 1781
Advantage: 55

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 1979
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: 571-85586718 +8613336195806
Fax: +86-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 29797
Advantage: 60

Beijing Mesochem Technology Co., Ltd.

Tel: 010-57862036 18811083386
Email: msales@mesochem.com
Country: China
ProdList: 189
Advantage: 58

Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Country: China
ProdList: 1988
Advantage: 58

Wuhan NewBaiChuan Pharmaceutical Co., Ltd.

Tel: 027-50476178
Fax: QQ644526144
Email: 644526144@qq.com
Country: China
ProdList: 418
Advantage: 58

Nanjing crow LuNing pharmaceutical technology co., LTD

Tel: 13382066392
Country: CHINA
ProdList: 4880
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3238
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 400-400-400-9004166 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52712
Advantage: 58

Shanghai Pinbo Industrial Development Co. Ltd.

Tel: 18321128505
Email: pinbochemical@163.com
Country: China
ProdList: 161
Advantage: 58

Wuhan Xinbaichuan Pharmaceutical Technology Co., Ltd.

Tel: 027-50478167
Fax: QQ 252994272
Email: 252994272@qq.com
Country: China
ProdList: 277
Advantage: 58

Jinan Guoding Pharmaceutical Technology Co., Ltd.

Tel: 13153106106
Fax: 053167801621
Email: sales@guodingpharma.com
Country: China
ProdList: 481
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9730
Advantage: 58

Wuhan belka pharmaceutical co., LTD

Tel: 17798255750
Email: 2326587775@qq.com
Country: CHINA
ProdList: 327
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10523
Advantage: 58

Finetech Industry Limited

Tel: +86-27-87465837 +8618971612321
Fax: 86 27 87772287
Email: info@finetechnology-ind.com
Country: China
ProdList: 9635
Advantage: 58

Wuhan Fortuna Chemical Co., Ltd

Tel: +86-27-59207850 +86-13986145403
Fax: 86-27-59524646
Email: info@fortunachem.com
Country: China
ProdList: 5989
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: 0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25363
Advantage: 58

Hefei Hirisun Pharmatech Co., Ltd

Tel: +8615056975894
Fax: 86-0551-62678551
Email: shawn@hirisunpharm.com
Country: CHINA
ProdList: 9923
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: 0571-85134551
Fax: 008657185134895
Email: info@afinechem.com
Country: CHINA
ProdList: 15377
Advantage: 58

Shanxi Xuanran Import and Export Trade Co., Ltd.

Tel: +8617735180244
Email: mike_yan@xuanranglobal.com
Country: CHINA
ProdList: 4022
Advantage: 58

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6313
Advantage: 58

Henan Weituxi Chemical Technology Co., Ltd.

Tel: 0371-63284658; 18135795563
Fax: QQ:2885349392
Email: 2885349392@qq.com
Country: China
ProdList: 9997
Advantage: 58

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Email: chemwill_asia@126.com
Country: CHINA
ProdList: 23931
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9414
Advantage: 58

Wuhan Shuangjin Fine Chemical Co., Ltd.

Tel: 027-51903003 15926256169
Fax: 027-51903003
Email: 773164315@qq.com
Country: China
ProdList: 60
Advantage: 58

HubeiwidelychemicaltechnologyCo.,Ltd

Tel: 18627774460
Email: faith@widelychemical.com
Country: CHINA
ProdList: 742
Advantage: 58

Less

View Lastest Price from GSK1120212 (DMSO solvate) manufacturers

Henan Fengda Chemical Co., Ltd

Product: GSK1120212 (DMSO solvate) 1187431-43-1
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-26

Senova Technology Co. Ltd.

Product: DMSO solvate 1187431-43-1
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 10KG
Release date: 2023-12-14

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Trametinib dimethyl sulfoxide 1187431-43-1
Price: US $0.00/G
Min. Order: 5G
Purity: 98%min
Supply Ability: 30kg/month
Release date: 2023-02-07

1187431-43-1, GSK1120212 (DMSO solvate)Related Search:

Trametinib Lenalidomide

GSK 1120212B

Trametinib dimethyl sulfoxide

GSK1120212 (DMSO solvate)

JTP-74057

TraMetinib (DMSO solvate)

TraMetinib DMSO (API)

GSK-1120212 dimethyl sulfoxide

N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide compound with (methylsulfinyl)methane (1:1)

154988

Trametinib DMSO solvate, >=98%

JTP-74057;GSK1120212

N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-1H,2H,3H,4H,6H,7H-pyrido[4,3-d]pyrimidin-1-yl}phenyl)acetamide

JTP-74057 (DMSO solvate)

rametinibdimethylsulfoxide

TIANFU 1187431-43-1 GSK1120212 (DMSO solvate)

Trametinib dimethyl sulfoxide，GSK1120212 (DMSO solvate)

N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide dimethyl sulfoxide complex

Enzastaurin Impurity 1 (Bisindolylmaleimide V)

Trametinib Impurity 28

DMSO solvate

1187431-43-1

C28H29FIN5O5S

C26H23FIN5O4C2H6OS