I2906

Product Name: I2906
CAS No.: 331963-29-2
Chemical Name: I2906
Synonyms: I2906;I-2906 (I 2906;1-ET-4-HO-2-OXO-1,2-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID N'-TRIDECANOYL-HYDRAZIDE;1-ET-4-HO-2-OXO-1,2-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID N'-TRIDECANOYL-HYDRAZIDE;1-Ethyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinecarboxylic acid 2-(1-oxotridecyl)hydrazide;3-Quinolinecarboxylic acid, 1-ethyl-1,2-dihydro-4-hydroxy-2-oxo-, 2-(1-oxotridecyl)hydrazide
CBNumber: CB92624182
Molecular Formula: C25H37N3O4
Formula Weight: 443.58
MOL File: 331963-29-2.mol

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I2906 Property

Boiling point:: 623.9±55.0 °C(Predicted)
Density: 1.132±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
pka: 4.50±1.00(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0829
Product name: I2906
Purity: 99.92%
Packaging: 100mg
Price: $134
Updated: 2021/12/16

ChemScene

Product number: CS-0829
Product name: I2906
Purity: 99.92%
Packaging: 500mg
Price: $446
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0303626
Product name: 1-ETHYL-4-HYDROXY-2-OXO-N'-TRIDECANOYL-1,2-DIHYDROQUINOLINE-3-CARBOHYDRAZIDE
Purity: 95.00%
Packaging: 5MG
Price: $502.4
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611370
Product name: I-2906
Packaging: 100mg
Price: $606.9
Updated: 2021/12/16

DC Chemicals

Product number: DC22386
Product name: I-2906
Purity: >98%
Packaging: 100mg
Price: $300
Updated: 2021/12/16

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I2906 Chemical Properties,Usage,Production

Uses

I2906 showed antimycobacterial and cytotoxic activity against mycobacterium tuberculosis. IC50 Value: Target: Antibacterial Under in vitro conditions, I2906 showed excellent antimycobacterial activities and low cytotoxicity. In a murine model infected with M. tuberculosis H37Rv, the reductions on bacterial loads of both lungs and spleen were statistically significant (p < 0.05) between I2906-treated mice and untreated controls after 4 weeks. Further, the colony-forming unit counts in the lungs were dramatically lower (p < 0.05) than that of isoniazid-treated mice by the addition of I2906 after 8 weeks. Moreover, survival rate was increased by I2906 treatment. For multidrug-resistant strain infection, bacterial counts were reduced significantly in the lungs and spleen due to I2906 treatment in comparison with data from untreated controls (p < 0.05).

References

[1] Lu, Jingning; Yue, Jun; Wu, Jing et al. In vitro and in vivo Activities of a New Lead Compound I2906 against Mycobacterium tuberculosis. Pharmacology (2010), 85(6), 365-371. DOI:10.1159/000299795

I2906 Preparation Products And Raw materials

Raw materials

Preparation Products

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I2906 Suppliers

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331963-29-2, I2906Related Search:

2-(2-Aminoethylamino)ethanol

I-2906 (I 2906

I2906

1-Ethyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinecarboxylic acid 2-(1-oxotridecyl)hydrazide

3-Quinolinecarboxylic acid, 1-ethyl-1,2-dihydro-4-hydroxy-2-oxo-, 2-(1-oxotridecyl)hydrazide

1-ET-4-HO-2-OXO-1,2-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID N'-TRIDECANOYL-HYDRAZIDE

331963-29-2