ChemicalBook > CAS DataBase List > NBD-556

NBD-556

Product Name
NBD-556
CAS No.
333353-44-9
Chemical Name
NBD-556
Synonyms
NBD-556;NBD-556, 10 mM in DMSO;NBD-556;NBD 556; NBD556;N-(4-Chlorophenyl)-N'-(2,2,6,6-tetramethylpiperidin-4-yl)oxalamide;N1-(4-Chlorophenyl)-N2-(2,2,6,6-tetramethylpiperidin-4-yl)oxalamide;N1-(4-Chlorophenyl)-N2-(2,2,6,6-tetramethyl-4-piperidinyl)-ethanediamide;Ethanediamide, N1-(4-chlorophenyl)-N2-(2,2,6,6-tetramethyl-4-piperidinyl)-;inhibit,HIV-1,fusion,virus-cell,Human immunodeficiency virus,NBD556,HIV,Inhibitor,gp120,CD4,NBD 556,NBD-556,mimetic
CBNumber
CB92624263
Molecular Formula
C17H24ClN3O2
Formula Weight
337.84
MOL File
333353-44-9.mol
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NBD-556 Property

Density 
1.20
storage temp. 
2-8°C
solubility 
DMSO: soluble15mg/mL, clear
form 
powder
color 
white to beige
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HS Code 
2933.39.9200
HazardClass 
6.1
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0812
Product name
NBD-556
Purity
≥98% (HPLC)
Packaging
5mg
Price
$95.2
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0812
Product name
NBD-556
Purity
≥98% (HPLC)
Packaging
25mg
Price
$482
Updated
2024/03/01
TCI Chemical
Product number
N1090
Product name
NBD-556
Purity
>98.0%(HPLC)
Packaging
25mg
Price
$261
Updated
2024/03/01
TCI Chemical
Product number
N1090
Product name
NBD-556
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$718
Updated
2024/03/01
Cayman Chemical
Product number
21274
Product name
NBD-556
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
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NBD-556 Chemical Properties,Usage,Production

Uses

NBD-556 is a N-phenyl-N''-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamide analog, a novel class of human immunodeficiency virus type 1 (HIV-1) entry inhibitors that block the gp120-CD4 interaction.

Uses

NBD-556 is a N-phenyl-N'-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamide analog, a novel class of human immunodeficiency virus type 1 (HIV-1) entry inhibitors that block the gp120-CD4 interaction.

Biological Activity

the entry of hiv-1 into host cells is mediated by the binding of the surface subunit gp120 to the host cell receptor cd4. nbd-556 is a novel class of human immunodeficiency virus type 1 (hiv-1) entry inhibitor that block the gp120–cd4 interaction with drug-like properties.

in vitro

a systematic study showed that nbd-556 and nbd-557 target viral entry by inhibiting the binding of hiv-1 envelope glycoprotein gp120 to the cellular receptor cd4 but did not inhibit reverse transcriptase, protease, or integrase, demonstrating that they do not target the later stages of the hiv-1 life cycle to inhibit hiv-1 infection. nbd-556 and nbd-557 were also active against hiv-1 laboratory-adapted strains including an azt-resistant strain and hiv-1 primary isolates, showing that these compounds can potentially be further modified to become potent hiv-1 entry inhibitors [1].

IC 50

nbd-556 inhibited cell–cell fusion between h9/hiv-1iiib and mt-2 (ic50 ~3 μm)

References

[1] zhao, q. , l. ma, s. jiang, h. lu, s. liu, y. he, n. strick, n. neamati, and a. k. debnath. 2005. identification of n-phenyl-n′-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of hiv-1 entry inhibitors that prevent gp120 binding to cd4. virology 339:213-225.

NBD-556 Preparation Products And Raw materials

Raw materials

Preparation Products

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NBD-556 Suppliers

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333353-44-9, NBD-556Related Search:


  • NBD-556
  • N-(4-Chlorophenyl)-N'-(2,2,6,6-tetramethylpiperidin-4-yl)oxalamide
  • N1-(4-Chlorophenyl)-N2-(2,2,6,6-tetramethyl-4-piperidinyl)-ethanediamide
  • NBD-556;NBD 556; NBD556
  • Ethanediamide, N1-(4-chlorophenyl)-N2-(2,2,6,6-tetramethyl-4-piperidinyl)-
  • N1-(4-Chlorophenyl)-N2-(2,2,6,6-tetramethylpiperidin-4-yl)oxalamide
  • inhibit,HIV-1,fusion,virus-cell,Human immunodeficiency virus,NBD556,HIV,Inhibitor,gp120,CD4,NBD 556,NBD-556,mimetic
  • NBD-556, 10 mM in DMSO
  • 333353-44-9