1H-Indole-3-ethanaMine, 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]Methyl]-
- Product Name
- 1H-Indole-3-ethanaMine, 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]Methyl]-
- CAS No.
- 467459-31-0
- Chemical Name
- 1H-Indole-3-ethanaMine, 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]Methyl]-
- Synonyms
- LU AE58054;LU AE58084;idalopirdine;LU AE58054(Idalopirdine);Idalopirdine(Lu-AE-58054);idalopirdine, 10 mM in DMSO;IDALOPIRDINE;LU AE 58054;LUAE58054;LU AE58054 HYDROCHLORIDE; LU AE 58054 HYDROCHLORIDE;N-[2-(6-Fluoro-1H-indol-3-yl)ethyl]-3-(2,2,3,3-tetrafluoropropoxy)benzylamine;6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl]-1H-Indole-3-ethanamine
- CBNumber
- CB92625336
- Molecular Formula
- C20H19F5N2O
- Formula Weight
- 398.37
- MOL File
- 467459-31-0.mol
1H-Indole-3-ethanaMine, 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]Methyl]- Property
- Boiling point:
- 500.9±50.0 °C(Predicted)
- Density
- 1.309±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- 25℃: DMSO
- form
- Powder
- pka
- 16.63±0.30(Predicted)
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 27335
- Product name
- LU AE58054
- Packaging
- 100mg
- Price
- $547
- Updated
- 2024/03/01
- Product number
- 27335
- Product name
- LU AE58054
- Packaging
- 250mg
- Price
- $1139
- Updated
- 2024/03/01
- Product number
- 27335
- Product name
- LU AE58054
- Packaging
- 25mg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 27335
- Product name
- LU AE58054
- Packaging
- 50mg
- Price
- $290
- Updated
- 2024/03/01
- Product number
- 453947
- Product name
- Lu AE58054
- Packaging
- 5mg
- Price
- $355
- Updated
- 2021/12/16
1H-Indole-3-ethanaMine, 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]Methyl]- Chemical Properties,Usage,Production
Uses
The selective and high affinity 5-?HT6 receptor antagonist Lu AE58054 as promising treatment for cognitive disorders, in particular for Alzheimer’s disease (AD).
Biological Activity
Idalopirdine (Lu AE58054) is an orally available, and potent antagonist of the serotonin 6 (5-HT6) receptor. Idalopirdine has been reported to be highly selective over other G-protein coupled receptors. It has K(d) of 0.2nM for the 5-HT6 receptor with 16-fold selectivity over the 5-HT2A receptor (K(i) 3.2nM) and >100-fold selectivity to all other evaluated targets.
1H-Indole-3-ethanaMine, 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]Methyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-Indole-3-ethanaMine, 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]Methyl]- manufacturers
- Product
- Lu Ae58054 467459-31-0
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-11-13
- Product
- 2-(6-fluoro-1H-indol-3-yl)-N-[[3-(2,2,3,3-tetrafluoropropoxy)phen yl]methyl]ethanamine 467459-31-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-23
- Product
- Lu AE58054 467459-31-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-20