2,6-bis(chloromethyl)-4-methylphenol Property

Melting point:

76-83 °C

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

RTECS 

OX6600000

Hazard and Precautionary Statements (GHS)

2,6-bis(chloromethyl)-4-methylphenol Chemical Properties,Usage,Production

Preparation

Synthesis of 2,6-bis(chloromethyl)-4-methylphenol: 2,6-Bis(hydroxymethyl)-p-cresol (2.5 g, 15 mmol) in CH2Cl2 (30 mL) was added to SOCl2 (10 mL, 140 mmol). After stirring for 12 h, the yellow mixture was washed with water and brine. The organic layer was dried with Na2SO4 and concentrated under the reduced pressure to give a white solid. Yield 2.8 g (92%).
1H-NMR (400 MHz, CDCl3): δ 7.09 (s, 2H), 5.52 (s, 1H), 4.66 (s, 4H), 2.28 (s, 3H).