ChemicalBook > CAS DataBase List > 4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl-

4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl-

Product Name
4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl-
CAS No.
1197300-24-5
Chemical Name
4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl-
Synonyms
CCDC;TGR5;CS-1017;MDK00245;TGR5 Receptor Agonist;CCDC(TGR5-Receptor-Agonist);TGR5 Receptor Agonist, >=98%;TGR5 Receptor Agonist(isoxazole);TGR5 Receptor Agonist, 10 mM in DMSO;BENZYL (4-CHLORO-1H-PYRROLO[2,3-B]PYRIDIN-1-YL)ACETATE
CBNumber
CB92627077
Molecular Formula
C18H14Cl2N2O2
Formula Weight
361.22
MOL File
1197300-24-5.mol
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4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl- Property

Boiling point:
541.8±50.0 °C(Predicted)
Density 
1.346±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml; Ethanol: 30 mg/ml
form 
A crystalline solid
pka
-0.52±0.50(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16291
Product name
TGR5 Receptor Agonist
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
16291
Product name
TGR5 Receptor Agonist
Purity
≥98%
Packaging
5mg
Price
$122
Updated
2024/03/01
Cayman Chemical
Product number
16291
Product name
TGR5 Receptor Agonist
Purity
≥98%
Packaging
10mg
Price
$214
Updated
2024/03/01
Cayman Chemical
Product number
16291
Product name
TGR5 Receptor Agonist
Purity
≥98%
Packaging
25mg
Price
$456
Updated
2024/03/01
Usbiological
Product number
T3662-50
Product name
TGR5 Receptor Agonist
Packaging
5mg
Price
$493
Updated
2021/12/16
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4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl- Chemical Properties,Usage,Production

Description

TGR5 receptor agonist is an agonist of the bile acid G protein-coupled receptor TGR5 (EC50s = 31.6-158.5 nM in cell-based assays). It stimulates cAMP formation in HEK293 cells expressing TGR5 (EC50 = 2.3 pM). TGR5 receptor agonist (1 mg/kg) increases glucagon-like peptide 1 (GLP-1) secretion and decreases glucose levels in the hepatic portal vein in dogs when administered in combination with glucose. It also inhibits the cytochrome P450 (CYP) isozymes CYP2C19 and CYP3A4 (IC50s = 316.2 and 1,259 nM, respectively).

4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl- Preparation Products And Raw materials

Raw materials

Preparation Products

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4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl- Suppliers

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View Lastest Price from 4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl- manufacturers

Career Henan Chemical Co
Product
4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl- 1197300-24-5
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-09-03

1197300-24-5, 4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl-Related Search:

Anti-GPR40

  • 4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl-
  • TGR5
  • 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl-4-IsoxazolecarboxaMide
  • TGR5 Receptor Agonist
  • 3-(2-CHLOROPHENYL)-N-(4-CHLOROPHENYL)-N,5-DIMETHYLISOXAZOLE-4-CARBOXAMIDE
  • 3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-4-isoxazolecarboxamide TGR5
  • TGR5 4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl-
  • TGR5 Receptor Agonist, >=98%
  • CCDC
  • BENZYL (4-CHLORO-1H-PYRROLO[2,3-B]PYRIDIN-1-YL)ACETATE
  • CCDC(TGR5-Receptor-Agonist)
  • CS-1017
  • MDK00245
  • 3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-1,2-oxazole-4-carboxamide
  • TGR5 Receptor Agonist(isoxazole)
  • TGR5 Receptor Agonist, TGR5 G-protein coupled receptor agonist
  • TGR5 Receptor Agonist, 10 mM in DMSO
  • 1197300-24-5
  • Inhibitors