A-443654

Product Name: A-443654
CAS No.: 552325-16-3
Chemical Name: A-443654
Synonyms: A-443654;A-443654 ，E1125;A-443654;A443654;A-443654, 10 mM in DMSO;inhibit,A443654,A-443654,Inhibitor,PKB,Akt,A 443654,Protein kinase B;(2S)-1-(1H-indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan-2-amine;(S)-1-(1H-Indol-3-yl)-3-((5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl)oxy)propan-2-amine;1H-Indole-3-ethanamine, α-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-, (αS)-;1H-Indole-3-ethanaMine, a-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]Methyl]-, (aS)-;(alphaS)-alpha-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-(S)-1H-indole-3-ethanamine
CBNumber: CB92627239
Molecular Formula: C24H23N5O
Formula Weight: 397.47
MOL File: 552325-16-3.mol

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A-443654 Property

Boiling point:: 722℃
Density: 1.307
Flash point:: 390℃
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥19.85 mg/mL in DMSO; ≥44.3 mg/mL in EtOH
form: solid
pka: 13.43±0.40(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16499
Product name: A-443654
Purity: ≥98%
Packaging: 500μg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 16499
Product name: A-443654
Purity: ≥98%
Packaging: 1mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 16499
Product name: A-443654
Purity: ≥98%
Packaging: 5mg
Price: $401
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: INB0001420
Product name: A-443654
Purity: 95.00%
Packaging: 5MG
Price: $503.87
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611401
Product name: A-443654
Packaging: 5mg
Price: $569.5
Updated: 2021/12/16

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A-443654 Chemical Properties,Usage,Production

Uses

A-443654 is a pan-Akt inhibitor and has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM)[1].

Definition

ChEBI: (2S)-1-(1H-indol-3-yl)-3-[[5-(3-methyl-2H-indazol-5-yl)-3-pyridinyl]oxy]-2-propanamine is a member of indoles.

in vivo

A-443654 (7.5 mg/kg/d, s.c.) inhibits tumor growth in the 3T3-Akt1 flank tumor model. A-443654 (50 mg/kg, s.c.) induces apoptosis in 3T3-Akt1 flank tumors. A-443654 (30 mg/kg, s.c.) leads to increased levels of phosphorylated Akt1 in MiaPaCa-2 tumors^[1].

target

Akt1

IC 50

Akt1: 160 pM (Ki); Akt2: 160 pM (Ki); Akt3: 160 pM (Ki); PKA: 6.3 nM (Ki); RSK2: 11 nM (Ki); PKCγ: 24 nM (Ki); CDK2: 24 nM (Ki); PKCδ: 33 nM (Ki); GSK3β: 41 nM (Ki); ERK2: 340 nM (Ki); cKIT: 1.2 μM (Ki); Chk1: 2.3 μM (Ki); CK2: 2.4 μM (Ki); SRC: 2.6 μM (Ki); KDR: 3.1 μM (Ki); MAPK-AP2: 3.3 μM (Ki); Flt1: 3.6 μM (Ki)

References

[1] Luo Y, et al. Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. Mol Cancer Ther. 2005 Jun;4(6):977-86. DOI:10.1158/1535-7163.MCT-05-0005
[2] Zheng J, et al. Rapamycin sensitizes Akt inhibition in malignant human breast epithelial cells. Cancer Lett. 2010 Oct 1;296(1):74-87. DOI:10.1016/j.canlet.2010.03.018
[3] Gallia GL, et al. Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells. Mol Cancer Ther. 2009 Feb;8(2):386-93. DOI:10.1158/1535-7163.MCT-08-0680
[4] Zhao Y, et al. Estrogen receptor alpha and beta regulate actin polymerization and spatial memory through an SRC-1/mTORC2-dependent pathway in the hippocampus of female mice. J Steroid Biochem Mol Biol. 2017 Nov;174:96-113. DOI:10.1016/j.jsbmb.2017.08.003

A-443654 Preparation Products And Raw materials

Raw materials

Preparation Products

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A-443654 Suppliers

China 79 United States 8 Global 87

BOC Sciences

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Hangzhou Sage Chemical Co., Ltd.

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Haoyuan Chemexpress Co., Ltd.

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AdooQ BioScience, LLC

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Jinan Mingya Medical Technology Co., Ltd.

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ShangHai Caerulum Pharma Discovery Co., Ltd.

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ShangHai KenEn Chemical Technology Co., Ltd.

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AdooQ Bioscience CHINA

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Shanghai Lollane Biological Technology Co.,Ltd.

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SPIRO PHARMA

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View Lastest Price from A-443654 manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: A-443654 552325-16-3
Price: US $2.00-5.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons
Release date: 2025-07-10

Career Henan Chemical Co

Product: A-443654 552325-16-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1lg; 2kg; 5kg; 10kg; 100kg
Release date: 2019-08-31

552325-16-3, A-443654Related Search:

A-443654

1H-Indole-3-ethanaMine, a-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]Methyl]-, (aS)-

(alphaS)-alpha-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-(S)-1H-indole-3-ethanamine

A-443654;A443654

(2S)-1-(1H-indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan-2-amine

1H-Indole-3-ethanamine, α-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-, (αS)-

inhibit,A443654,A-443654,Inhibitor,PKB,Akt,A 443654,Protein kinase B

A-443654, 10 mM in DMSO

(S)-1-(1H-Indol-3-yl)-3-((5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl)oxy)propan-2-amine

A-443654 ，E1125

552325-16-3

Akt

mTOR

PI3K