ChemicalBook > CAS DataBase List > LeterMovir

LeterMovir

Product Name
LeterMovir
CAS No.
917389-32-3
Chemical Name
LeterMovir
Synonyms
Lettmove;AIC246;MK-8828;CS-2799;Letemovir;LeterMovir;Letermovlr;D3-Letermovir;LeterMovir-005;Letermovir (AIC246)
CBNumber
CB92627305
Molecular Formula
C29H28F4N4O4
Formula Weight
572.55
MOL File
917389-32-3.mol
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LeterMovir Property

Boiling point:
706.5±70.0 °C(Predicted)
Density 
1.37±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
≥57.3 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form 
solid
pka
4.00±0.10(Predicted)
color 
Off-white to yellow
InChI
InChI=1S/C29H28F4N4O4/c1-40-20-6-3-5-19(16-20)35-11-13-36(14-12-35)28-34-27-21(7-4-8-22(27)30)23(17-26(38)39)37(28)24-15-18(29(31,32)33)9-10-25(24)41-2/h3-10,15-16,23H,11-14,17H2,1-2H3,(H,38,39)/t23-/m0/s1
InChIKey
FWYSMLBETOMXAG-QHCPKHFHSA-N
SMILES
N1C2=C(C=CC=C2F)[C@H](CC(O)=O)N(C2=CC(C(F)(F)F)=CC=C2OC)C=1N1CCN(C2=CC=CC(OC)=C2)CC1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3891
Product name
Letermovir
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$174.8
Updated
2025/07/31
Sigma-Aldrich
Product number
SML3891
Product name
Letermovir
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$739
Updated
2025/07/31
Cayman Chemical
Product number
17556
Product name
Letermovir
Purity
≥98%
Packaging
1mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
17556
Product name
Letermovir
Purity
≥98%
Packaging
5mg
Price
$324
Updated
2024/03/01
Cayman Chemical
Product number
17556
Product name
Letermovir
Purity
≥98%
Packaging
10mg
Price
$502
Updated
2024/03/01
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LeterMovir Chemical Properties,Usage,Production

Uses

Letermovir acts as an orally or i.v administered cytomegalovirus terminus complex inhibitor, antiviral agent, used in the treatment of CMV infection which is prevalent in those with immunocompromised systems.

Biological Activity

Letermovir (AIC246) is an orally active, potent and selective human cytomegalovirus (HCMV) DNA terminase complex inhibitor th at blocks HCMV replication (EC50 = 0.9-3.1 nM among 17 clinial HCMV isolates; EC50 = 1.6-3.9 nM against 6 AD169-derived drug-resistant variants) by interfering with viral DNA cleavage/packaging. Letermovir exhibits little potency toward MCMV (Smith), RCMV (Maastricht), VZV (Oka), HSV-1 (166v VP22-GFP), HSV-2 (01-6332), HHV-6 (typeA-GS) or EBV (B95-8) (MCMV EC50 = 4.5 μM, all other EC50 >10 μM).

in vivo

Letermovir (10-100 mg/kg/day, p.o.) leads to a dose-dependent reduction of the HCMV titer in transplanted cells compared to that of the placebo-treated control group using the mouse xenograft model[3].

LeterMovir Preparation Products And Raw materials

Raw materials

Preparation Products

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LeterMovir Suppliers

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View Lastest Price from LeterMovir manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
LeterMovir 917389-32-3
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-11-26
Wuhan Biocar Pharmacy CO.,Ltd.
Product
LeterMovir 917389-32-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
580kg
Release date
2025-02-24
Strong peptide cross-border e-commerce Co. LTD
Product
LeterMovir 917389-32-3
Price
US $40.00-35.00/box
Min. Order
1box
Purity
99.9+
Supply Ability
2000box
Release date
2024-06-07

917389-32-3, LeterMovirRelated Search:

2-Propenoic acid, 3-[3-fluoro-2-[[[[2-methoxy-5-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]-, methyl ester, (2E)- 2-Propenoic acid, 3-[3-fluoro-2-[[[4-(3-methoxyphenyl)-1-piperazinyl][[2-methoxy-5-(trifluoromethyl)phenyl]imino]methyl]amino]phenyl]-, methyl ester, (2E)- Bortezomib

  • AIC246
  • LeterMovir
  • (4S)-8-Fluoro-3,4-dihydro-2-[4-(3-methoxyphenyl)-1-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-4-quinazolineacetic acid
  • AIC246;AIC 246;AIC-246
  • CS-2799
  • 4-Quinazolineacetic acid, 8-fluoro-3,4-dihydro-2-[4-(3-methoxyphenyl)-1-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-, (4S)-
  • Letermovir (AIC246)
  • MK-8828
  • LeterMovir-005
  • Lettmove
  • methyl(S)-2-(8-fluoro-3-(2-methoxy-5-(trifluoromethyl)phenyl)-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetate
  • Letermovir-d6Q: What is Letermovir-d6 Q: What is the CAS Number of Letermovir-d6
  • LetermovirQ: What is Letermovir Q: What is the CAS Number of Letermovir
  • (S)-2-(8-Fluoro-3-(2-methoxy-5-(trifluoromethyl)phenyl)-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetic acid
  • Letermovlr
  • LeterMovir Impurity 27
  • Cilnidipine Impurity 29
  • Letermovir, 10 mM in DMSO
  • Letemovir
  • (S)-{8-fluoro-2-[4-(3-methoxyphenyl)piperazine-1-yl]-3-(2-methoxy-5-trifluoromethylphenyl)-3,4-dihydroquinazoline-4-yl}acetic acid
  • D3-Letermovir
  • 917389-32-3
  • 1616761-00-3
  • C29H28F4N4O4
  • API
  • 917389-32-3