ChemicalBook > CAS DataBase List > AP1903

AP1903

Product Name
AP1903
CAS No.
195514-63-7
Chemical Name
AP1903
Synonyms
AP1903;CS-1237;Rimiducidum;Rimiducid(AP1903);AP1903 (Rimiducid;AP1903;RIMIDUCID;AP-1903;Rimiducid, 10 mM in DMSO;RIMIDUCID;AP-1903;AP 1903;Rimiducid (AP1903) ，S9726;2-Piperidinecarboxylic acid, 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-, 2,2'-[1,2-ethanediylbis[imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene[(1R)-3-(3,4-dimethoxyphenyl)propylidene]]] ester, (2S,2'S)-
CBNumber
CB92627330
Molecular Formula
C78H98N4O20
Formula Weight
1411.63
MOL File
195514-63-7.mol
More
Less

AP1903 Property

Boiling point:
1307.5±65.0 °C(Predicted)
Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO:97.05(Max Conc. mg/mL);68.75(Max Conc. mM)
Ethanol:120.58(Max Conc. mg/mL);85.42(Max Conc. mM)
form 
A solid
pka
13.70±0.46(Predicted)
color 
White to light yellow
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Tocris
Product number
6130
Product name
AP1903
Purity
≥98%(HPLC)
Packaging
5
Price
$335
Updated
2021/12/16
ApexBio Technology
Product number
B4168
Product name
AP1903
Packaging
50mg
Price
$1425
Updated
2021/12/16
ChemScene
Product number
CS-3162
Product name
Rimiducid
Purity
99.81%
Packaging
50mg
Price
$1680
Updated
2021/12/16
ApexBio Technology
Product number
B4168
Product name
AP1903
Packaging
100mg
Price
$1995
Updated
2021/12/16
ChemScene
Product number
CS-3162
Product name
Rimiducid
Purity
99.81%
Packaging
100mg
Price
$2280
Updated
2021/12/16
More
Less

AP1903 Chemical Properties,Usage,Production

Biological Activity

AP1903 (Rimiducid) is a dimerizing agent that acts by cross-linking the FKBP domain, initiating Fas signaling and causing apoptosis.It dimerizes the Caspase 9 suicide switch and rapidly induces apoptosis.

in vitro

The human fibrosarcoma line HT1080 is engineered to express stably a fusion protein comprising a myristoylation sequence, two copies of F36V-FKBP, and the human first apoptosis signal (Fas) intracellular domain. Rimiducid (AP1903) elicits potent and dose-dependent apoptotic death of these engineered cells in culture, with an EC 50 of ≈0.1 nM. Maximal killing occurred in the presence of 3 to 10 nM Rimiducid (AP1903), and the IC 50 is approximately 0.2 nM. LV′VFas-transduced T lymphocytes expressing high levels of CD25 (top panel) are eliminated by with 66%±7.5% (n=10) efficiency. When cells are examined after CD25 expression returned to basal levels, 63%±4.7% (n=9) killing is observed after Rimiducid treatment.

in vivo

AP1903 elicits a dose-dependent decrease in serum human GH levels, with a half-maximal effective dose of 0.4±0.1 mg /kg.

target

EC50: 0.1 nM (FKBP, in HT1080 cells)
Fas receptor

storage

Store at -20°C

AP1903 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

AP1903 Suppliers

China 94 United States 10 Global 104
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
Country
China
ProdList
1077
Advantage
64
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
Advantage
64
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1493
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Nanjing Dulai Biotechnology Co., Ltd.
Tel
025-846993838003-8003 18013301590
Fax
025-84699383-8003
Email
njduly@126.com
Country
China
ProdList
3249
Advantage
55
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Birdo (Shanghai) Medical Technology Co., Ltd.
Tel
021-58099077
Fax
-
Email
sales@birdochem.com
Country
China
ProdList
185
Advantage
55
Shanghai TBBMed Co.,Ltd
Tel
021-50498136 13564881053
Fax
021-50498136
Email
products@tbbmed.com
Country
China
ProdList
184
Advantage
55

195514-63-7, AP1903Related Search:


  • AP1903
  • Rimiducid(AP1903)
  • AP1903;RIMIDUCID;AP-1903
  • AP1903 (Rimiducid
  • CS-1237
  • RIMIDUCID;AP-1903;AP 1903
  • 2-Piperidinecarboxylic acid, 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-, 2,2'-[1,2-ethanediylbis[imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene[(1R)-3-(3,4-dimethoxyphenyl)propylidene]]] ester, (2S,2'S)-
  • (1R,1'R)-((((Ethane-1,2-diylbis(azanediyl))bis(2-oxoethane-2,1-diyl))bis(oxy))bis(3,1-phenylene))bis(3-(3,4-dimethoxyphenyl)propane-1,1-diyl) (2S,2'S)-bis(1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate)
  • (S,2S,2'S)-(1R,1'R)-((((ethane-1,2-diylbis(azanediyl))bis(2-oxoethane-2,1-diyl))bis(oxy))bis(3,1-phenylene))bis(3-(3,4-dimethoxyphenyl)propane-1,1-diyl) bis(1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate)
  • Rimiducid, 10 mM in DMSO
  • Rimiducidum
  • Rimiducid (AP1903) ，S9726
  • 195514-63-7
  • C78H98N4O20