ATH 686

Product Name: ATH 686
CAS No.: 853299-52-2
Chemical Name: ATH 686
Synonyms: ATH 686;ATH686, 10 mM in DMSO;1-[4-(2-AMinopyriMidin-4-yloxy)phenyl]-3-[4-[(4-ethylpiperazin-1-yl)Methyl]-3-trifluoroMethylphenyl]urea;1-{4-[(2-Amino-4-pyrimidinyl)oxy]phenyl}-3-{4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl}urea;Urea, N-[4-[(2-amino-4-pyrimidinyl)oxy]phenyl]-N'-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-;ATH686,inhibit,CD135,Inhibitor,Apoptosis,ATH-686,ATP-competitive,FLT3,antileukemic,Fms like tyrosine kinase 3,autophosphorylation,Cluster of differentiation antigen 135
CBNumber: CB92627350
Molecular Formula: C25H28F3N7O2
Formula Weight: 515.53
MOL File: 853299-52-2.mol

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ATH 686 Property

Density: 1.364±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 250 mg/mL (484.94 mM; Need ultrasonic)
pka: 13.32±0.70(Predicted)
form: Solid
color: White to light brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC10921
Product name: ATH686
Purity: >98%
Packaging: 1g
Price: $2600
Updated: 2021/12/16

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ATH 686 Chemical Properties,Usage,Production

Uses

ATH686 is a potent, selective and ATP-competitive FLT3 inhibitor. ATH686 target mutant FLT3 protein kinase activity and inhibit the proliferation of cells harboring FLT3 mutants via induction of apoptosis and cell cycle inhibition. ATH686 has antileukemic effects[1].

Biological Activity

ATH686 is a potent, selective and ATP-competitive FLT3 inhibitor. ATH686 target mutant FLT3 protein kinase activity and inhibit the proliferation of cells harboring FLT3 mutants via induction of apoptosis and cell cycle inhibition. ATH686 has antileukemic effects[1]. ATH686 (1-100 μM; 3 days) potently inhibits cell proliferation (IC50 around 0.001 μM) via induction of apoptosis in FLT3-ITD-Ba/F3 cells and D835Y-Ba/F3 cells[1]. ATH686 (10 nM; for 15 minutes) inhibits autophosphorylation of mutant FLT3 in FLT3-ITD-Ba/F3 cells[1].

References

[1]. Ellen Weisberg, et al. Antileukemic Effects of Novel First- and Second-Generation FLT3 Inhibitors: Structure-Affinity Comparison. Genes Cancer. 2010 Oct;1(10):1021-32.

ATH 686 Preparation Products And Raw materials

Raw materials

Preparation Products

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ATH 686 Suppliers

China 22 United States 4 Global 26

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 88915
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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9550
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32467
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
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Shanghai Dongyang Biotechnology Co., Ltd.

Tel: 0512-13601744364 13601744364
Email: chemsharker@126.com
Country: China
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Chengdu Peter-like Biotechnology Co., Ltd.

Tel: 18108052721 18108052721;
Email: 2850505130@qq.com
Country: China
ProdList: 5088
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InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
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TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
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Shanghai Yiyan Biotechnology Co. , Ltd.

Tel: 021-69985186 13611928337
Email: 3427709316@qq.com
Country: China
ProdList: 7982
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853299-52-2, ATH 686Related Search:

ATH 686

1-[4-(2-AMinopyriMidin-4-yloxy)phenyl]-3-[4-[(4-ethylpiperazin-1-yl)Methyl]-3-trifluoroMethylphenyl]urea

ATH686,inhibit,CD135,Inhibitor,Apoptosis,ATH-686,ATP-competitive,FLT3,antileukemic,Fms like tyrosine kinase 3,autophosphorylation,Cluster of differentiation antigen 135

Urea, N-[4-[(2-amino-4-pyrimidinyl)oxy]phenyl]-N'-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-

ATH686, 10 mM in DMSO

1-{4-[(2-Amino-4-pyrimidinyl)oxy]phenyl}-3-{4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl}urea

853299-52-2