DG 051 (HCl salt)
- Product Name
- DG 051 (HCl salt)
- CAS No.
- 929915-58-2
- Chemical Name
- DG 051 (HCl salt)
- Synonyms
- DG051;DG051 (DG-051;DG 051 (HCl salt);DG051,Aminopeptidase,inhibit,DG 051,Inhibitor,DG-051;(2S)-2-[[4-(4-Chlorophenoxy)phenoxy]methyl]-1-pyrrolidinebutanoic Acid Hydrochloride;4-((S)-2-((4-(4-chlorophenoxy)phenoxy)Methyl)pyrrolidin-1-yl)butanoic acid hydrochloride
- CBNumber
- CB92627754
- Molecular Formula
- C21H25Cl2NO4
- Formula Weight
- 426.3335
- MOL File
- 929915-58-2.mol
DG 051 (HCl salt) Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 20 mg/ml; DMSO: 12.5 mg/ml; Ethanol: 12.5 mg/ml; PBS (pH 7.2): 2 mg/ml
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 21688
- Product name
- DG-051
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 21688
- Product name
- DG-051
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 21688
- Product name
- DG-051
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- 21688
- Product name
- DG-051
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $533
- Updated
- 2024/03/01
- Product number
- C381365
- Product name
- (2S)-2-[[4-(4-Chlorophenoxy)phenoxy]methyl]-1-pyrrolidinebutanoicAcidHydrochloride
- Packaging
- 100mg
- Price
- $1365
- Updated
- 2021/12/16
DG 051 (HCl salt) Chemical Properties,Usage,Production
Description
DG-051 is a potent, orally bioavailable leukotriene A4 hydrolase (LTA4H) inhibitor (Kd = 25 nM; IC50 = 47 nM), the enzyme that catalyzes the rate-determining step in the synthesis of LTB4 . However, it also inhibits the aminopeptidase activity of LTA4H with IC50 values of 72 and 150 nM when tested using the substrates L-alanine p-nitroanaline and prolyl-glycyl-proline peptide (PGP; ), respectively, potentially leading to PGP accumulation in vivo. DG-051 does not show any inhibitory activity against a panel of more than 50 additional aminopeptidases, ion channels, or HERG.
Uses
(2S)?-2-?[[4-?(4-Chlorophenoxy)?phenoxy]?methyl]?-1-?pyrrolidinebutanoic Acid Hydrochloride is a potent inhibitor leukotriene A4 hydrolase (LTA4H), which is a therapeutic target for developing treatments for cardiovascular diseases and cancers.
DG 051 (HCl salt) Preparation Products And Raw materials
Raw materials
Preparation Products
DG 051 (HCl salt) Suppliers
View Lastest Price from DG 051 (HCl salt) manufacturers
- Product
- DG 051 (HCl salt) 929915-58-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 96%
- Supply Ability
- 500kg
- Release date
- 2018-08-20