Dofequidar fuMarate
- Product Name
- Dofequidar fuMarate
- CAS No.
- 153653-30-6
- Chemical Name
- Dofequidar fuMarate
- Synonyms
- Dofequidar fumarate, 10 mM in DMSO;Dofequidar (2E)-2-butenedioate (1:1);Dofequidar,Inhibitor,MS209,CD243,ABCB1,MS 209,Dofequidar fumarate,Multidrug resistance protein 1,Cluster of differentiation 243,P-gp,P-glycoprotein,MDR1,inhibit,Pgp
- CBNumber
- CB92627774
- Molecular Formula
- C34H35N3O7
- Formula Weight
- 597.6576
- MOL File
- 153653-30-6.mol
Dofequidar fuMarate Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Powder
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-2041
- Product name
- Dofequidar fumarate
- Purity
- 99.99%
- Packaging
- 10mg
- Price
- $156
- Updated
- 2021/12/16
- Product number
- CS-2041
- Product name
- Dofequidar fumarate
- Purity
- 99.99%
- Packaging
- 5mg
- Price
- $96
- Updated
- 2021/12/16
- Product number
- CS-2041
- Product name
- Dofequidar fumarate
- Purity
- 99.99%
- Packaging
- 50mg
- Price
- $600
- Updated
- 2021/12/16
- Product number
- B1167
- Product name
- Dofequidar fumarate
- Packaging
- 50mg
- Price
- $805
- Updated
- 2021/12/16
- Product number
- CS-2041
- Product name
- Dofequidar fumarate
- Purity
- 99.99%
- Packaging
- 100mg
- Price
- $1020
- Updated
- 2021/12/16
Dofequidar fuMarate Chemical Properties,Usage,Production
Biological Activity
dofequidar fumarate is a multidrug-resistant (mdr) - reversal agent [1].dofequidar fumarate is a quinoline derivative and has highly potent reversing effect on multidrug-resistant tumor cells. it prevents the transport of antitumor drugs through interacting with the drug-efflux pump p-glycoprotein directly and thereby reverses mdr. in vincristine (vcr)-resistant p388/vcr cells and adriamycin (adm)- resistant p388/adm cells, dofequidar fumarate at 1μm and 3μm can completely reverse the drug resistance. it also shows significant effects on the mdr k562 cells. furthermore, in mice model bearing hct-15 xenografts, combination therapy of dofequidar fumarate and docetaxel induces remarkable tumor growth inhibition. dofequidar fumarate also shows significant reversing effect in mcf-7/adm-bearing mice [1, 2].
References
[1] sato w, fukazawa n, nakanishi o, et al. reversal of multidrug resistance by a novel quinoline derivative, ms-209. cancer chemotherapy and pharmacology, 1995, 35(4): 271-277.
[2] naito m, matsuba y, sato s, et al. ms-209, a quinoline-type reversal agent, potentiates antitumor efficacy of docetaxel in multidrug-resistant solid tumor xenograft models. clinical cancer research, 2002, 8(2): 582-588.
Dofequidar fuMarate Preparation Products And Raw materials
Raw materials
Preparation Products
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